Association of the ABCB1 gene with risk for uveal melanoma

Saakian S.V.

Moscow Helmholtz Research Institute of Eye Diseases, Moscow, Russia

Amirian A.G.

FGBU "Moskovskiĭ NII glaznykh bolezneĭ im. Gel'mgol'tsa" Minzdrava Rossii

Tsygankov A.Iu.

FGBU "Moskovskiĭ NII glaznykh bolezneĭ im. Gel'mgol'tsa" Minzdrava Rossii

Loginov V.I.

Institute of General Pathology and Pathophysiology, 8 Baltiiskaya St., Moscow, Russian Federation, 125315

SPIN RSCI: 6249-5883
Scopus AuthorID: 7102884943
ORCID: 0000-0003-2668-8096

Burdennyy A.M.

Institute of General Pathology and Pathophysiology, 8 Baltiiskaya St., Moscow, Russian Federation, 125315

Association of the ABCB1 gene with risk for uveal melanoma

Authors:

Saakian S.V., Amirian A.G., Tsygankov A.Iu., Loginov V.I., Burdennyy A.M.

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Journal: Russian Journal of Archive of Pathology. 2014;76(2): 3‑7

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To cite this article:

Saakian SV, Amirian AG, Tsygankov AIu, Loginov VI, Burdennyy AM. Association of the ABCB1 gene with risk for uveal melanoma. Russian Journal of Archive of Pathology. 2014;76(2):3‑7. (In Russ.)

Подписка 2025-2 (Russian Journal of Archive of Pathology)

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The study investigated the association of the ABCB1 C3435T polymorphism gene with the risk for uveal melanoma (UM). Genotyping was carried out using the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) analysis. All the tumors under study were histologically verified. The patients with UM were found to have a high frequency of predisposing alleles and genotypes of this polymorphism in the patients with UM. The CC genotype of the ABCB1 C3435T polymorphism was shown to be associated with the increased risk of UM (OR=8.5; p=7∙10-6). A significant correlation was first found between the frequency of the CC genotype of the ABCB1 C3435T polymorphism and the height of a tumor and degree of its pigmentation (p=0.0391 and p=0.0381, respectively, Fisher's test). A marginal association was first shown between the CC genotype of the ABCB1 C3435T polymorphism and the vascular state and histological type.

Keywords:

C3435T polymorphism

ABCB1 gene

P-glycoprotein

uveal melanoma

Authors:

Saakian S.V.

Moscow Helmholtz Research Institute of Eye Diseases, Moscow, Russia

Amirian A.G.

FGBU "Moskovskiĭ NII glaznykh bolezneĭ im. Gel'mgol'tsa" Minzdrava Rossii

Tsygankov A.Iu.

FGBU "Moskovskiĭ NII glaznykh bolezneĭ im. Gel'mgol'tsa" Minzdrava Rossii

Loginov V.I.

Institute of General Pathology and Pathophysiology, 8 Baltiiskaya St., Moscow, Russian Federation, 125315

SPIN RSCI: 6249-5883
Scopus AuthorID: 7102884943
ORCID: 0000-0003-2668-8096

Burdennyy A.M.

Institute of General Pathology and Pathophysiology, 8 Baltiiskaya St., Moscow, Russian Federation, 125315

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