Leukocyte telomere length changes following various anesthetic methods in patients with severe combined trauma

Kuchina S.N.; Shchegolev A.V.; Myakoshina L.A.; Khachiyan V.Sh.; Spivak I.M.

doi:https://doi.org/10.17116/anaesthesiology202505122

Kuchina S.N.

Kirov Military Medical Academy

ORCID: 0000-0001-7893-3183

Shchegolev A.V.

Kirov Military Medical Academy

SPIN RSCI: 4107-6860
Scopus AuthorID: 7003338841
ResearcherID: J-4326-2013
ORCID: 0000-0001-6431-439X

Myakoshina L.A.

Kirov Military Medical Academy

ORCID: 0000-0002-2498-6201

Khachiyan V.Sh.

Kirov Military Medical Academy

ORCID: 0009-0007-4395-6159

Spivak I.M.

Kirov Military Medical Academy;
Saint Petersburg State University

ORCID: 0000-0003-1351-8696

Leukocyte telomere length changes following various anesthetic methods in patients with severe combined trauma

Authors:

Kuchina S.N., Shchegolev A.V., Myakoshina L.A., Khachiyan V.Sh., Spivak I.M.

More about the authors

Journal: Russian Journal of Anesthesiology and Reanimatology. 2025;(5): 22‑27

DOI: 10.17116/anaesthesiology202505122

Read: 692 times

To cite this article:

Kuchina SN, Shchegolev AV, Myakoshina LA, Khachiyan VSh, Spivak IM. Leukocyte telomere length changes following various anesthetic methods in patients with severe combined trauma. Russian Journal of Anesthesiology and Reanimatology. 2025;(5):22‑27. (In Russ., In Engl.)
https://doi.org/10.17116/anaesthesiology202505122

Использование инфографики авторами научных работ

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Abstract:

BACKGROUND

In recent decades, the number of surgical interventions has increased in the world. In clinical practice, it is not always possible to assess long-term changes/complications/outcomes. The other side of technological progress includes patient satisfaction with medical care and desire for active longevity. Quality and safety of anesthesia, as well as its impact on humans are actively discussed in global community. Epigenetics is one of the new directions in anesthesiology. At the moment, the effect of anesthesia on genome is not established.

OBJECTIVE

To study leukocyte telomere length in patients with severe concomitant trauma undergoing repeated anesthesia.

MATERIAL AND METHODS

A prospective cohort study included 41 victims with severe combined trauma. The first group included patients who underwent regional anesthesia with propofol sedation (RA), the second group — general combined anesthesia (GA). Twice blood sampling was performed for laboratory diagnostics. We analyzed leukocyte telomere length using real-time PCR before treatment and 4 weeks after admission.

RESULTS

There were no significant between-group differences after 4 weeks (p=0.933). In the first group, there was significantly shorter leukocyte telomere length in 4 weeks after admission (p=0.002282).

CONCLUSION

General anesthesia does not affect the length of leucocyte telomeres. Telomere shortening was observed after regional anesthesia, but appropriate values were within normal limits. Probably, this shortening was short-term, and restoration of baseline telomere length is possible. It is not possible to answer the question about the causes of telomere shortening unambiguously. Further studies of epigenetic aspects of anesthesiology are needed.

Keywords:

leukocyte telomere length

severe combined injury

multiple anesthetics

epigenetics

Authors:

Kuchina S.N.

Kirov Military Medical Academy

ORCID: 0000-0001-7893-3183

Shchegolev A.V.

Kirov Military Medical Academy

SPIN RSCI: 4107-6860
Scopus AuthorID: 7003338841
ResearcherID: J-4326-2013
ORCID: 0000-0001-6431-439X

Myakoshina L.A.

Kirov Military Medical Academy

ORCID: 0000-0002-2498-6201

Khachiyan V.Sh.

Kirov Military Medical Academy

ORCID: 0009-0007-4395-6159

Spivak I.M.

Kirov Military Medical Academy;
Saint Petersburg State University

ORCID: 0000-0003-1351-8696

Received:

26.02.2025

Accepted:

02.04.2025

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References:

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