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A.E. Bautin

Almazov National Medical Research Center

K.Yu. Afanasyeva

Almazov National Medical Research Center

A.O. Marichev

Almazov National Medical Research Centre

A.M. Radovskiy

Almazov National Medical Research Center

E.K. Barygin

Almazov National Medical Research Center

A.K. Gusenova

Almazov National Medical Research Center

I.G. Chomakhashvili

Almazov National Medical Research Center

N.V. Badalyan

Almazov National Medical Research Center

M.S. Zhuravleva

Almazov National Medical Research Center

A.M. Pozhidaeva

Almazov National Medical Research Center

Impact of inhaled gas compound on nitric dioxide release in a model of nitric oxide inhalation therapy (experimental study)

Authors:

A.E. Bautin, K.Yu. Afanasyeva, A.O. Marichev, A.M. Radovskiy, E.K. Barygin, A.K. Gusenova, I.G. Chomakhashvili, N.V. Badalyan, M.S. Zhuravleva, A.M. Pozhidaeva

More about the authors

Journal: Russian Journal of Anesthesiology and Reanimatology. 2024;(1): 23‑30

DOI: 10.17116/anaesthesiology202401123

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Table of contents

IMPACT OF INHALED GAS COMPOUND ON NITRIC DIOXIDE RELEASE IN A MODEL OF NITRIC OXIDE INHALATION THERAPY (EXPERIMENTAL STUDY)
IMPACT OF INHALED GAS COMPOUND ON NITRIC DIOXIDE RELEASE IN A MODEL OF NITRIC OXIDE INHALATION THERAPY (EXPERIMENTAL STUDY)

To cite this article:

Bautin AE, Afanasyeva KYu, Marichev AO, Radovskiy AM, Barygin EK, Gusenova AK, Chomakhashvili IG, Badalyan NV, Zhuravleva MS, Pozhidaeva AM. Impact of inhaled gas compound on nitric dioxide release in a model of nitric oxide inhalation therapy (experimental study). Russian Journal of Anesthesiology and Reanimatology. 2024;(1):23‑30. (In Russ., In Engl.)
https://doi.org/10.17116/anaesthesiology202401123

Здоровье щитовидной железы – 2024
Перекрестки терапевтических проблем
Доказательная гастроэнтерология: pro et contra
Актуальные вопросы педиатрической практики
NN - давайте знакомится (08.04.2024)
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BACKGROUND

Toxic effects of nitric dioxide (NO2) released under nitric oxide (NO) inhalation limit the application of nitric oxide high-dose therapy of clinical conditions accompanied by increased pulmonary vascular resistance.

OBJECTIVE

To identify the combinations of safe NO and O2 concentrations in inhaled gas compound for nitric dioxide release in a model of NO insufflation through the «Tianox» apparatus into respiratory circuit.

MATERIAL AND METHODS

The study was performed on an experimental model. There were 360 measurements of NO2 content in 72 various combinations of NO and O2.

RESULTS

NO2 release depended on NO and O2 content in gas mixture. Multivariate regression analysis confirmed this fact. NO2 concentration <2 ppm was recognized as a safe value. ROC-analysis confirmed predictive ability of NO and O2 regarding toxic NO2 concentrations. In case of inhalation therapy through the «Tianox» apparatus with any NO concentrations (10—80 ppm), O2 content in gas mixture within 21—30% was safe. NO concentration <50 ppm is safe at any O2 content in gas mixture (21—100%).

CONCLUSION

There is a fundamentally new source of NO in the Tianox device (synthesis from atmospheric air). We obtained data on possible safe combinations of inhaled O2 and NO regarding NO2 release for effective clinical use of this device.

Keywords:

nitric oxide
nitric dioxide
“Tianox” device
pulmonary vascular resistance
experimental stand

Authors:

A.E. Bautin

Almazov National Medical Research Center

K.Yu. Afanasyeva

Almazov National Medical Research Center

A.O. Marichev

Almazov National Medical Research Centre

A.M. Radovskiy

Almazov National Medical Research Center

E.K. Barygin

Almazov National Medical Research Center

A.K. Gusenova

Almazov National Medical Research Center

I.G. Chomakhashvili

Almazov National Medical Research Center

N.V. Badalyan

Almazov National Medical Research Center

M.S. Zhuravleva

Almazov National Medical Research Center

A.M. Pozhidaeva

Almazov National Medical Research Center

Received:

03.08.2023

Accepted:

22.09.2023

List of references:

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