Abstract Pheochromocytoma and paraganglioma are relatively rare neuroendocrine tumors growing from adrenal medulla or chromaffin cells of extra-adrenal sympathetic or parasympathetic ganglia releasing catecholamines. Excessive catecholamines secretion may be followed by myocardial injury including specific dilated cardiomyopathy (takotsubo syndrome). Diagnosis of this cardiomyopathy often seems to be difficult due to atypical manifestations or unusual clinical context. In this report takotsubo syndrome with acute left ventricular failure and pulmonary edema developed immediately after right-sided adrenalectomy in 25 years old female. Echocardiography confirmed decrease of LV ejection fraction from 75 to 53% with irregularly reduced LV contractility up to apical akinesis and moderate mitral regurgitation. Intensive care and hemodynamic monitoring led to regression of symptoms and recovery. The aim of our case report is to demonstrate the possibility of takotsubo syndrome after adrenalectomy and the necessity of its prompt correction in any patient with pheochromocytoma or paraganglioma.