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Sertakova A.V.

Razumovsky Saratov State Medical University;
Research Institute of Traumatology, Orthopedics and Neurosurgery of the Razumovsky Saratov State Medical University

Galashina E.A.

Razumovsky Saratov State Medical University

Afanasieva G.A.

Razumovsky Saratov State Medical University

Complex regional pain syndrome (CRPS): pathophysiological aspects

Authors:

Sertakova A.V., Galashina E.A., Afanasieva G.A.

More about the authors

Journal: Russian Journal of Pain. 2025;23(3): 82‑92

DOI: 10.17116/pain20252303182

Read: 362 times

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Table of contents

COMPLEX REGIONAL PAIN SYNDROME (CRPS): PATHOPHYSIOLOGICAL ASPECTS
COMPLEX REGIONAL PAIN SYNDROME (CRPS): PATHOPHYSIOLOGICAL ASPECTS

To cite this article:

Sertakova AV, Galashina EA, Afanasieva GA. Complex regional pain syndrome (CRPS): pathophysiological aspects. Russian Journal of Pain. 2025;23(3):82‑92. (In Russ.)
https://doi.org/10.17116/pain20252303182

 
Подписка 2025 Российский журнал боли (Russian Journal of Pain)
МСФ на ЯМ
Использование инфографики авторами научных работ
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Abstract:

OBJECTIVE

To analyze modern data on CRPS, its complexities and pathophysiological mechanisms, as well as treatment of this debilitating illness.

MATERIAL AND METHODS

The eLibrary, PubMed, Springer, Cyberleninka databases were screened over the last 5—8 years. The review presents modern information on diverse pathophysiological mechanisms of CRPS (neural, inflammatory, vascular, immune aspects, as well as independent triggers). Various reviews, including systemic ones were preferable. Studies published more than 5 years ago were used in historical aspect or in case of description of important experimental results.

RESULTS

The article describes such aspects of CRPS as genetic predisposition, trauma, microcirculatory disorders, impaired autonomic dysfunction, inflammation, oxidative stress and autoimmune pathology.

CONCLUSION

CRPS is characterized by inter-individual heterogeneity and even intra-individual variability. Thus, both genetic predisposition and environmental influences contribute to CRPS, and patients have changes in peripheral and central nervous system. Inflammation and neuroimmune interactions are essential in CRPS. Autoimmune mechanisms include IgG-mediated neuroinflammation and IgM-mediated enhancement of nociception.

Keywords:

complex regional pain syndrome
Sudeck’s syndrome
algodystrophy
reflex sympathetic dystrophy

Authors:

Sertakova A.V.

Razumovsky Saratov State Medical University;
Research Institute of Traumatology, Orthopedics and Neurosurgery of the Razumovsky Saratov State Medical University

Galashina E.A.

Razumovsky Saratov State Medical University

Afanasieva G.A.

Razumovsky Saratov State Medical University

Received:

05.02.2025

Accepted:

03.03.2025

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