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Sergalieva M.U.

Astrakhan State Medical University

Tsibizova A.A.

Astrakhan State Medical University

Krintsova T.A.

Astrakhan State Medical University

Samotrueva M.A.

Astrakhan State Medical University

Opioid peptides: physiological role, molecular mechanisms and pharmacological activity

Authors:

Sergalieva M.U., Tsibizova A.A., Krintsova T.A., Samotrueva M.A.

More about the authors

Journal: Russian Journal of Pain. 2023;21(3): 43‑49

DOI: 10.17116/pain20232103143

Read: 5057 times

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Table of contents

OPIOID PEPTIDES: PHYSIOLOGICAL ROLE, MOLECULAR MECHANISMS AND PHARMACOLOGICAL ACTIVITY
OPIOID PEPTIDES: PHYSIOLOGICAL ROLE, MOLECULAR MECHANISMS AND PHARMACOLOGICAL ACTIVITY

To cite this article:

Sergalieva MU, Tsibizova AA, Krintsova TA, Samotrueva MA. Opioid peptides: physiological role, molecular mechanisms and pharmacological activity. Russian Journal of Pain. 2023;21(3):43‑49. (In Russ.)
https://doi.org/10.17116/pain20232103143

 
Подписка 2025 Российский журнал боли (Russian Journal of Pain)
МСФ на ЯМ
Использование инфографики авторами научных работ
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Abstract:

This review is devoted to searching for new safe pharmacologically active compounds. One of the perspective areas in this field is development of the drugs based on regulatory peptides. To date, opioid peptides are of particular interest among these compounds. It is a group of bioregulatory factors with diverse functions and effects. Opioid peptides are characterized by simple chemical formula consisting of amino acid residues. We discuss physiological role, molecular mechanisms and pharmacological activity of the main representatives of opioid peptides (leucine and methionine enkephalins, sedatin, β-endorphin, octorphin, dalargin, etc.). According to literature data, opioid peptides have a wide range of pharmacological activity. These are perspective compounds for further research related to the study of functional activity of nervous, immune and endocrine systems.

Keywords:

opioid peptides
dynorphins
sedatin
β-endorphin
octorphin
dalargyne
pharmacological activity

Authors:

Sergalieva M.U.

Astrakhan State Medical University

Tsibizova A.A.

Astrakhan State Medical University

Krintsova T.A.

Astrakhan State Medical University

Samotrueva M.A.

Astrakhan State Medical University

Received:

01.03.2023

Accepted:

20.04.2023

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