Hexaazaizowurtzitane derivate as a new analgesic for chronic pain syndrome relief in experimental rheumatoid artritis

Krylova S.G.; Lopatina K.A.; Zueva E.P.; Safonova E.A.; Rybalkina O.Yu.; Povetyeva T.N.; Suslov N.I.; Kulagina D.A.; Sysolyatin S.V.; Zhdanov V.V.

doi:https://doi.org/10.17116/pain2020180315

Krylova S.G.

Goldberg Research Institute of Pharmacology and Regenerative Medicine

Lopatina K.A.

Goldberg Research Institute of Pharmacology and Regenerative Medicine

Zueva E.P.

Goldberg Research Institute of Pharmacology and Regenerative Medicine

Safonova E.A.

Goldberg Research Institute of Pharmacology and Regenerative Medicine

Rybalkina O.Yu.

Goldberg Research Institute of Pharmacology and Regenerative Medicine

Povetyeva T.N.

Goldberg Research Institute of Pharmacology and Regenerative Medicine

Suslov N.I.

Goldberg Research Institute of Pharmacology and Regenerative Medicine

Kulagina D.A.

Institute of Problems of Chemical-Energetic Technologies

Sysolyatin S.V.

Institute of Problems of Chemical-Energetic Technologies

Zhdanov V.V.

Goldberg Research Institute of Pharmacology and Regenerative Medicine

Hexaazaizowurtzitane derivate as a new analgesic for chronic pain syndrome relief in experimental rheumatoid artritis

Authors:

Krylova S.G., Lopatina K.A., Zueva E.P., Safonova E.A., Rybalkina O.Yu., Povetyeva T.N., Suslov N.I., Kulagina D.A., Sysolyatin S.V., Zhdanov V.V.

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Journal: Russian Journal of Pain. 2020;18(3): 5‑10

DOI: 10.17116/pain2020180315

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To cite this article:

Krylova SG, Lopatina KA, Zueva EP, et al. . Hexaazaizowurtzitane derivate as a new analgesic for chronic pain syndrome relief in experimental rheumatoid artritis. Russian Journal of Pain. 2020;18(3):5‑10. (In Russ.)
https://doi.org/10.17116/pain2020180315

Подписка 2025 Российский журнал боли (Russian Journal of Pain)

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OBJECTIVE

The study anti-inflammatory and analgesic activity of new pharmaceutical substance dosage form (DF) based on hexaazaizowurtzitane (Thiowurtzine) in chronic intragastric administration at a dose of 100 mg/kg in rats with experimental adjuvant arthritis.

MATERIAL AND METHODS

Experimental study was performed on SD male rats. Chronic immune inflammation was modeled by injection of Freund’s adjuvant into the paw (BCG suspension 2.5 mg/ml in vaseline oil). Study drugs (Meloxicam 10 mg/kg and Thiowurtzine 100 mg/kg) have been administered for 30 days into the stomach through a tube. Inflammatory response was evaluated every 2—3 days. We also evaluated adjuvant-induced generalized reactions (edema of the ears, tail, polyarthritis, weight loss, death). Analgesic effect of both drugs was assessed considering behavioral reaction score (vocalization) after irritation of the inflamed paw.

RESULTS

Thiowurtzine at a dose of 100 mg/kg per os ensured anti-inflammatory effect only at the peak of inflammation (the 10^th days of edema). Anti-inflammatory activity was significantly less compared to Meloxicam. However, thiowurtzine was characterized by more active analgesic effect. The last one was significantly higher compared to Meloxicam.

Keywords:

analgesic

thiowurtzine

hexaazaizowurtzitane

adjuvant arthritis

Authors:

Krylova S.G.

Goldberg Research Institute of Pharmacology and Regenerative Medicine

Lopatina K.A.

Goldberg Research Institute of Pharmacology and Regenerative Medicine

Zueva E.P.

Goldberg Research Institute of Pharmacology and Regenerative Medicine

Safonova E.A.

Goldberg Research Institute of Pharmacology and Regenerative Medicine

Rybalkina O.Yu.

Goldberg Research Institute of Pharmacology and Regenerative Medicine

Povetyeva T.N.

Goldberg Research Institute of Pharmacology and Regenerative Medicine

Suslov N.I.

Goldberg Research Institute of Pharmacology and Regenerative Medicine

Kulagina D.A.

Institute of Problems of Chemical-Energetic Technologies

Sysolyatin S.V.

Institute of Problems of Chemical-Energetic Technologies

Zhdanov V.V.

Goldberg Research Institute of Pharmacology and Regenerative Medicine

Received:

25.03.2020

Accepted:

15.06.2020

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References:

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