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Evolution of methodological standards for systematic reviews and meta-analysis protocol on the influence of molecular genetic profile of meningioma on tumor recurrence

Evolution of methodological standards for systematic reviews and meta-analysis protocol on the influence of molecular genetic profile of meningioma on tumor recurrence

Authors:
Глеб Сергеевич Сергеев,
Михаил Васильевич Нестерчук,
Владимир Сергеевич Климов,
Алексей Сергеевич Гайтан,
Владислав Владимирович Куфтов,
Глеб Валерьевич Данилов,
Николай Александрович Коновалов,
Дмитрий Юрьевич Усачев,
Алексей Леонидович Кривошапкин

Журнал: Вопросы нейрохирургии имени Н.Н. Бурденко. 2026;90(4):114-121.

DOI: 10.17116/neiro202690041114

Read: 1145 раз

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Abstract

BACKGROUND

Traditional histological classification of meningiomas has low prognostic accuracy and necessitates integration of molecular biomarkers. However, current data are fragmented and require rigorous synthesis.

OBJECTIVE

To develop a meta-analysis protocol for quantitative assessment of the influence of molecular profile of meningiomas on long-term outcomes (overall survival and recurrence-free period) after surgical or combined treatment.

MATERIAL AND METHODS

The article provides historical analysis of transformation of evidence-based medicine standards from narrative reviews to algorithmic guidelines (QUOROM, MOOSE, PRISMA). The choice of the PRISMA-P 2020 protocol and Cochrane methodology as the standard for this study is justified.

RESULTS

A meta-analysis design was developed to assess the impact of genetic profile (TERT, CDKN2A/B, NF2 status, DNA methylation) on the risk of recurrence. Inclusion criteria (PICOTS) cover all types of meningiomas. The protocol regulates searching strategy, independent screening (Rayyan) and risk of bias assessment using the QUIPS tool. Statistical synthesis of data is planned to identify the hierarchy of risk factors.

CONCLUSION

Implementation of this protocol will ensure creation of a valid evidence base for stratification of risk of meningioma recurrence based on molecular genetic profile.

Keywords

  • meningioma
  • tumor recurrence
  • molecular genetic profile
  • progression risk stratification
  • DNA methylation-based classification
  • CDKN2A/B deletion and TERT
  • systematic review and meta-analysis

Дата поступления: 16.01.2026

Дата принятия в печать: 07.05.2026

Дата публикации: 07.08.2026

References
  1. Price M, Ballard C, Benedetti J, Neff C, Cioffi G, Waite KA, Kruchko C, Barnholtz-Sloan JS, Ostrom QT. CBTRUS Statistical Report: Primary Brain and Other Central Nervous System Tumors Diagnosed in the United States in 2017—2021. Neuro-Oncology. 2024;26(Suppl 6):vi1-vi85. https://doi.org/10.1093/neuonc/noae145
  2. Quach S, Simon M. Diagnostic advances and challenges in meningioma. Expert Review of Neurotherapeutics. 2025;25(10):1209-1221. https://doi.org/10.1080/14737175.2025.2548327
  3. Trybula SJ, Youngblood MW, Karras CL, Murthy NK, Heimberger AB, Lukas RV, Sachdev S, Kalapurakal JA, Chandler JP, Brat DJ, Horbinski CM, Magill ST. The Evolving Classification of Meningiomas: Integration of Molecular Discoveries to Inform Patient Care. Cancers. 2024;16(9):1753. https://doi.org/10.3390/cancers16091753
  4. Ali RH, Hassan A, Jarkhi HH, Alshawish A, Almanabri M, Alhalabi OT, Alsaber AR, Ali NY, Abdelnabi E, Mohammed EMA, Jama H, Almarzooq A, Alqallaf Z, Ahmed AA, Bahzad S, Hamelmann S, Sahm F, Almurshed M. Molecular and histopathological landscape of 131 meningiomas: a retrospective institutional study with insights from cIMPACT-NOW. Frontiers in Oncology. 2025;15:1648953. https://doi.org/10.3389/fonc.2025.1648953
  5. Szulzewsky F, Thirimanne HN, Holland EC. Meningioma: current updates on genetics, classification, and mouse modeling. Upsala Journal of Medical Sciences. 2024;129(S1):e10579. https://doi.org/10.48101/ujms.v129.10579
  6. Wach J, Lampmann T, Güresir Á, Vatter H, Becker AJ, Hölzel M, Toma M, Güresir E. Combining FORGE Score and Histopathological Diagnostic Criteria of Atypical Meningioma Enables Risk Stratification of Tumor Progression. Diagnostics. 2021;11(11):2011. https://doi.org/10.3390/diagnostics11112011
  7. Marastoni E, Barresi V. Meningioma Grading beyond Histopathology: Relevance of Epigenetic and Genetic Features to Predict Clinical Outcome. Cancers. 2023;15(11):2945. https://doi.org/10.3390/cancers15112945
  8. Cucu AI, Costea CF, Turliuc Ş, Blaj LA, Prutianu I, Dumitrescu GF, Dascălu CG, Poeată I, Coşman M, Istrate AC, Macovei G, Tătăranu LG. Predictor factors for recurrence in atypical meningiomas. Romanian Journal of Morphology and Embryology. 2023;64(3):333-342. https://doi.org/10.47162/rjme.64.3.05
  9. Macarthur JI, Hannan CJ, Howard C, Halliday J, Pathmanaban ON, Hammerbeck-Ward C, Rutherford SA, King AT. Recurrence of Resected Skull Base Meningiomas during Long-term Follow-up: Incidence and Predisposing Factors. Journal of Neurological Surgery Part B: Skull Base. 2024;86(3):245-253. https://doi.org/10.1055/s-0044-1786370
  10. Ungureanu G, Serban LN, Florian SI. Optimizing Surgical Management of Anterior Skull Base Meningiomas: Imaging Modalities, Key Surgical Considerations, and Risk Mitigation Strategies. Cancers. 2025;17(6):987. https://doi.org/10.3390/cancers17060987
  11. Louis DN, Perry A, Wesseling P, Brat DJ, Cree IA, Figarella-Branger D, Hawkins C, Ng HK, Pfister SM, Reifenberger G, Soffietti R, von Deimling A, Ellison DW. The 2021 WHO Classification of Tumors of the Central Nervous System: a summary. Neuro-Oncology. 2021;23(8):1231-1251. https://doi.org/10.1093/neuonc/noab106
  12. Sergeev GS, Gaytan AS, Travin MA, Ponomarev AB, Afonina MA, Savitskaya IA, Yakhya F, Krivoshapkin AL. Impact of molecular genetic profile of meningiomas on the clinical course and recurrence using combined modality treatment. Siberian Journal of Oncology. 2023;22(6):138-152. (In Russ.). https://doi.org/10.21294/1814-4861-2023-22-6-138-152
  13. Groff KJ, Patel RV, Feng Y, Ghosh HS, Millares Chavez MA, O’Brien J, Chen WC, Nitturi V, Save AV, Youngblood MW, Horbinski CM, Chandler JP, Ehret F, Gui C, Wang JZ, Park K, Ajmera S, Rosenblum M, Suwala AK, Kresbach C, Mount CW, Schüller U, Santagata S, Sahm F, Bale TA, Jackson C, Richardson TE, Cai C, Nassiri F, Zadeh G, Kaul D, Capper D, Magill ST, Golfinos JG, Sen C, Patel AJ, Raleigh DR, Moliterno J, Pacione D, Snuderl M, Bi WL. The effect of TERT promoter mutation on predicting meningioma outcomes: a multi-institutional cohort analysis. The Lancet Oncology. 2025;26(9):1178-1190. https://doi.org/10.1016/s1470-2045(25)00422-x
  14. Wach J, Basaran AE, Arlt F, Vychopen M, Seidel C, Barrantes-Freer A, Müller W, Gaunitz F, Güresir E. CDKN2A/B deletions are strongly associated with meningioma progression: a meta-analysis of individual patient data. Acta Neuropathologica Communications. 2023;11(1):189. https://doi.org/10.1186/s40478-023-01690-y
  15. Soni N, Ora M, Bathla G, Szekeres D, Desai A, Pillai JJ, Agarwal A. Meningioma: Molecular Updates from the 2021 World Health Organization Classification of CNS Tumors and Imaging Correlates. American Journal of Neuroradiology. 2025;46(2):240-250. https://doi.org/10.3174/ajnr.a8368
  16. Deska-Gauthier D, Hachem LD, Wang JZ, Landry AP, Yefet L, Gui C, Ellengbogen Y, Badhiwala J, Zadeh G, Nassiri F. Clinical, molecular, and genetic features of spinal meningiomas. Neuro-Oncology Advances. 2024;6(Suppl 3):iii73-iii82. https://doi.org/10.1093/noajnl/vdae123
  17. Greenhalgh T, Thorne S, Malterud K. Time to challenge the spurious hierarchy of systematic over narrative reviews? European Journal of Clinical Investigation. 2018;48(6):e12931. https://doi.org/10.1111/eci.12931
  18. Moher D, Liberati A, Tetzlaff J, Altman DG. Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. BMJ. 2009;339:b2535. https://doi.org/10.1136/bmj.b2535
  19. Matino D, Chai-Adisaksopha C, Iorio A. Systematic reviews of prognosis studies: a critical appraisal of five core clinical journals. Diagnostic and Prognostic Research. 2017;1:9. https://doi.org/10.1186/s41512-017-0008-z
  20. Page MJ, McKenzie JE, Bossuyt PM, Boutron I, Hoffmann TC, Mulrow CD, Shamseer L, Tetzlaff JM, Akl EA, Brennan SE, Chou R, Glanville J, Grimshaw JM, Hróbjartsson A, Lalu MM, Li T, Loder EW, Mayo-Wilson E, McDonald S, McGuinness LA, Stewart LA, Thomas J, Tricco AC, Welch VA, Whiting P, Moher D. The PRISMA 2020 statement: an updated guideline for reporting systematic reviews. BMJ. 2021;372:n71. https://doi.org/10.1136/bmj.n71
  21. McGuinness LA, Higgins JPT. Risk-of-bias VISualization (robvis): An R package and Shiny web app for visualizing risk-of-bias assessments. Research Synthesis Methods. 2021;12(1):55-61. https://doi.org/10.1002/jrsm.1411
  22. DerSimonian R, Kacker R. Random-effects model for meta-analysis of clinical trials: an update. Contemporary Clinical Trials. 2007;28(2):105-114. https://doi.org/10.1016/j.cct.2006.04.004
  23. Zhai C, Guyatt G. Fixed-effect and random-effects models in meta-analysis. Chinese Medical Journal. 2024;137(1):1-4. https://doi.org/10.1097/cm9.0000000000002814
  24. Parmar MK, Torri V, Stewart L. Extracting summary statistics to perform meta-analyses of the published literature for survival endpoints. Statistics in Medicine. 1998;17(24):2815-2834. https://doi.org/10.1002/(sici)1097-0258(19981230)17:24<2815::aid-sim110>3.0.co;2-8
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