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Vetlova E.R.

Burdenko Neurosurgical Center

Banov S.M.

Burdenko Neurosurgical Center

Golanov A.V.

Burdenko Neurosurgical Center;
Russian Medical Academy of Continuous Professional Education

Pronin I.N.

Burdenko Neurosurgical Center

Antipina N.A.

Burdenko Neurosurgical Center

Galkin M.V.

Burdenko National Medical Research Center for Neurosurgery

Results of hypofractionated stereotactic radiotherapy for resected and intact large brain metastases

Authors:

Vetlova E.R., Banov S.M., Golanov A.V., Pronin I.N., Antipina N.A., Galkin M.V.

More about the authors

Journal: Burdenko's Journal of Neurosurgery. 2023;87(6): 67‑75

DOI: 10.17116/neiro20238706167

Read: 1832 times

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Table of contents

RESULTS OF HYPOFRACTIONATED STEREOTACTIC RADIOTHERAPY FOR RESECTED AND INTACT LARGE BRAIN METASTASES
RESULTS OF HYPOFRACTIONATED STEREOTACTIC RADIOTHERAPY FOR RESECTED AND INTACT LARGE BRAIN METASTASES

To cite this article:

Vetlova ER, Banov SM, Golanov AV, Pronin IN, Antipina NA, Galkin MV. Results of hypofractionated stereotactic radiotherapy for resected and intact large brain metastases. Burdenko's Journal of Neurosurgery. 2023;87(6):67‑75. (In Russ., In Engl.)
https://doi.org/10.17116/neiro20238706167

Подписка 2025 Журнал «Вопросы нейрохирургии» имени Н.Н. Бурденко (Burdenko's Journal of Neurosurgery)
 
МСФ на ЯМ
Использование инфографики авторами научных работ
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Abstract:

Post-resection or isolated hypofractionated stereotactic radiotherapy (HF-SRT) is a therapeutic option for large brain metastases (>2 cm, LBMs).

OBJECTIVE

To compare the results of post-resection or isolated HF-SRT in patients with LBMs.

MATERIAL AND METHODS

A prospective study included 115 patients with 129 intact LBMs and 133 patients with 149 resected LBMs who underwent HF-SRT. Median baseline focal size was 22.5 and 28 mm, median target volume — 8.3 and 23.7 cm3, respectively.

RESULTS

Median follow-up was 13.9 months, median overall survival — 19.1 months. After 12 months, local recurrences developed in 17 and 31% of patients, respectively (p=0.0078). Local recurrence after 12 months developed in 23% of patients with residual tumor in postoperative cavity compared to 16% of patients after total resection (p=0.0073). After 12 months, incidence of leptomeningeal progression was 27 and 11%, respectively (p=0.033), incidence of symptomatic radiation-induced necrosis — 4 and 23%, respectively (p=0.0006).

CONCLUSION

Post-resection HF-SRT demonstrated better local control and less severe symptomatic radiation-induced necrosis compared to patients with intact LBMs. Incidence of leptomeningeal progression is significantly higher after resection of LBMs.

Keywords:

stereotactic radiotherapy
hypofractionation
large brain metastases

Authors:

Vetlova E.R.

Burdenko Neurosurgical Center

Banov S.M.

Burdenko Neurosurgical Center

Golanov A.V.

Burdenko Neurosurgical Center;
Russian Medical Academy of Continuous Professional Education

Pronin I.N.

Burdenko Neurosurgical Center

Antipina N.A.

Burdenko Neurosurgical Center

Galkin M.V.

Burdenko National Medical Research Center for Neurosurgery

Received:

24.08.2023

Accepted:

14.09.2023

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