Autologous fibrin glue for endoscopic skull base repair in patients with cerebrospinal fluid leakage

Shelesko EV, Doronina VA, Sharipov OI, Kvan OK, Chernikova NA, Strunina YuV, Zinkevich DN. Autologous fibrin glue for endoscopic skull base repair in patients with cerebrospinal fluid leakage. Burdenko's Journal of Neurosurgery. 2023;87(1):49‑54. (In Russ., In Engl.)
https://doi.org/10.17116/neiro20238701149

Подписка 2025 Журнал «Вопросы нейрохирургии» имени Н.Н. Бурденко (Burdenko's Journal of Neurosurgery)

Использование инфографики авторами научных работ

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OBJECTIVE

To analyze efficacy and safety of Vivostat autologous fibrin glue for endoscopic skull base repair in patients with nasal CSF leakage and to compare postoperative outcomes after defect closure by Vivostat fibrin glue and allogeneic fibrin glue.

MATERIAL AND METHODS

A retro- and prospective analysis included 56 patients with nasal CSF leakage who were treated at the Burdenko Neurosurgery Center between January 2021 and June 2022. Patients were divided into 2 groups: Vivostat fibrin glue (n=27, 48.2%) and allogeneic fibrin glue (n=29, 51.8%). Demographic and clinical perioperative data were analyzed.

RESULTS

No early postoperative recurrence of CSF leakage was registered in both groups, whereas meningitis occurred in 2 cases in each group. Recurrent CSF leakage in delayed postoperative period occurred in 1 patient (3.4%) of the control group (p>0.05). Incidence of perioperative complications, subfebrile temperature in early postoperative period, surgery time and hospital-stay were similar.

CONCLUSION

Vivostat autologous fibrin glue is a safe and effective method for fixing the grafts in endoscopic skull base repair. The advantages of this approach are easy application, elimination of the risk of allergic, immunological and infectious complications, as well as acceleration of tissue regeneration.

Keywords:

nasal cerebrospinal fluid leakage

Vivostat autologous fibrin glue

skull base surgery

endoscopic endonasal surgery

Authors:

Shelesko E.V.

Burdenko National Medical Research Center of Neurosurgery

ORCID: 0000-0002-8249-9153

Doronina V.A.

Burdenko National Scientific and Practical Center for Neurosurgery

ORCID: 0000-0002-2484-481X

Sharipov O.I.

N.N. Burdenko National Medical Research Center of Neurosurgery of the Ministry of Health of the Russian Federation

ORCID: 0000-0003-3777-5662

Kvan O.K.

Burdenko Neurosurgical Center

ORCID: 0000-0002-6147-7887

Chernikova N.A.

Burdenko National Medical Research Center of Neurosurgery

ORCID: 0000-0002-4895-233X

Strunina Yu.V.

Burdenko Neurosurgical Center

ORCID: 0000-0003-1696-4050

Zinkevich D.N.

Burdenko National Medical Research Center of Neurosurgery

ORCID: 0000-0003-1295-0612

Received:

08.09.2022

Accepted:

18.11.2022

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References:

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