The site of the Media Sphera Publishers contains materials intended solely for healthcare professionals.
By closing this message, you confirm that you are a certified medical professional or a student of a medical educational institution.

Abdali A.

Peoples’ Friendship University of Russia

Astafyeva L.I.

Burdenko Neurosurgical Center

Trunin Yu.Yu.

Burdenko Neurosurgical Center

Chernov I.V.

Burdenko Neurosurgical Center

Sidneva Yu.G.

Burdenko Neurosurgical Center

Abdilatipov A.A.

Burdenko Neurosurgical Center

Kalinin P.L.

Burdenko Neurosurgery Center

Modern aspects of surgery for cushing’s disease

Authors:

Abdali A., Astafyeva L.I., Trunin Yu.Yu., Chernov I.V., Sidneva Yu.G., Abdilatipov A.A., Kalinin P.L.

More about the authors

Journal: Burdenko's Journal of Neurosurgery. 2021;85(4): 111‑117

Read: 3412 times


To cite this article:

Abdali A, Astafyeva LI, Trunin YuYu, Chernov IV, Sidneva YuG, Abdilatipov AA, Kalinin PL. Modern aspects of surgery for cushing’s disease. Burdenko's Journal of Neurosurgery. 2021;85(4):111‑117. (In Russ., In Engl.)
https://doi.org/10.17116/neiro202185041111

Recommended articles:
Myco­tic pseudoaneurysm of inte­rnal caro­tid artery in chro­nic fungal infe­ction. S.S. Korsakov Journal of Neurology and Psychiatry. 2025;(9):151-156

References:

  1. Bertagna X. Management of endocrine disease: Can we cure Cushing’s disease? A personal view. European Journal of Endocrinology. 2018;178(5):183-200.  https://doi.org/10.1530/EJE-18-0062
  2. Iglesias P, Rodriguez Berrocal V, Diez JJ. Giant pituitary adenoma: histological types, clinical features and therapeutic approaches. Endocrine. 2018;61(3):407-421.  https://doi.org/10.1007/s12020-018-1645-x
  3. Youssef AS, Agazzi S, van Loveren HR. Transcranial Surgery for Pituitary Adenomas. Neurosurgery. 2005;57(1 suppl):168-175.  https://doi.org/10.1227/01.NEU.0000163602.05663.86
  4. Pratheesh R, Rajaratnam S, Prabhu K, Mani SE, Chacko G, Chacko AG. The current role of transcranial surgery in the management of pituitary adenomas. Pituitary. 2013;16(4):419-434.  https://doi.org/10.1007/s11102-012-0439-z
  5. Broersen LHA, Biermasz NR, van Furth WR, de Vries F, Verstegen MJT, Dekkers OM, Pereira AM. Endoscopic vs. microscopic transsphenoidal surgery for Cushing’s disease: a systematic review and meta-analysis. Pituitary. 2018;21(5):524-534.  https://doi.org/10.1007/s11102-018-0893-3
  6. Komotar RJ, Starke RM, Raper DM, Anand VK, Schwartz TH. Endoscopic endonasal compared with microscopic transsphenoidal and open transcranial resection of giant pituitary adenomas. Pituitary. 2012;15(2):150-159.  https://doi.org/10.1007/s11102-011-0359-3
  7. Powell M. Microscope and endoscopic pituitary surgery. Acta Neurochirurgica. 2009;151(7):723-728.  https://doi.org/10.1007/s00701-009-0297-2
  8. Blevins LS, Sanai N, Kunwar S, Devin JK. An approach to the management of patients with residual Cushing’s disease. Journal of Neuro-Oncology. 2009;94(3):313-319.  https://doi.org/10.1007/s11060-009-9888-2
  9. Grigor’ev AYu. Nejrohirurgicheskoe lechenie pacientov s bolezn’yu Icenko-Kushinga i akromegaliej: Dis. ... d-ra med. nauk. M. 2011. (In Russ.).
  10. Chandler WF, Barkan AL, Hollon T, Sakharova A, Sack J, Brahma B, Schteingart DE. Outcome of Transsphenoidal Surgery for Cushing Disease: A Single-Center Experience Over 32 Years. Neurosurgery. 2016;78(2):216-223.  https://doi.org/10.1227/NEU.0000000000001011
  11. Ciric I. Pituitary tumors. Neurologic Clinics. 1985;3(4):751-768. 
  12. Hardy J. Transsphenoidal hypophysectomy. Journal of Neurosurgery. 1971;34(4):582-594.  https://doi.org/10.3171/jns.1971.34.4.0582
  13. Hardy J, Vezina JL. Transsphenoidal neurosurgery of intracranial neoplasm. Advances in Neurology. 1976;15:261-273. 
  14. Jagannathan J, Smith R, DeVroom HL, Vortmeyer AO, Stratakis CA, Nieman LK, Oldfield EH. Outcome of using the histological pseudocapsule as a surgical capsule in Cushing disease. Journal of Neurosurgery. 2009;111(3):531-539.  https://doi.org/10.3171/2008.8.JNS08339
  15. Biller BMK, Grossman AB, Stewart PM, Melmed S, Bertagna X, Bertherat J, Buchfelder M, Colao A, Hermus AR, Hofland LJ, Klibanski A, Lacroix A, Lindsay JR, Newell-Price J, Nieman LK, Petersenn S, Sonino N, Stalla GK. Treatment of Adrenocorticotropin-Dependent Cushing’s Syndrome: A Consensus Statement. The Journal of Clinical Endocrinology and Metabolism. 2008;93(7):2454-2462. https://doi.org/10.1210/jc.2007-2734
  16. Newell-Price J, Bertagna X, Grossman AB, Nieman LK. Cushing’s syndrome. Lancet. 2006;367(9522):1605-1617. https://doi.org/10.1016/S0140-6736(06)68699-6
  17. Pivonello R, De Martino MC, De Leo M, Lombardi G, Colao A. Cushing’s syndrome. Endocrinology and Metabolism Clinics of North America. 2008;37(1):135-ix.  https://doi.org/10.1016/j.ecl.2007.10.010
  18. Hur KY, Kim JH, Kim BJ, Kim MS, Lee EJ, Kim SW. Clinical Guidelines for the Diagnosis and Treatment of Cushing’s Disease in Korea. Endocrinology and Metabolism. 2015;30(1):7-18.  https://doi.org/10.3803/EnM.2015.30.1.7
  19. Miller JW, Crapo L. The medical treatment of Cushing’s syndrome. Endocrine Reviews. 1993;14(4):443-458.  https://doi.org/10.1210/edrv-14-4-443
  20. Beauregard C, Dickstein G, Lacroix A. Classic and recent etiologies of Cushing’s syndrome: diagnosis and therapy. Treatments in Endocrinology. 2002;1(2):79-94.  https://doi.org/10.2165/00024677-200201020-00002
  21. Chen S, Xu S, Lin F, Zhang X, Liu F, Dong M, Li X, Ma X. Endoscopic surgical treatment of Cushing’s disease: A single-center experience of cauterization of peritumoral tissues. Experimental and Therapeutic Medicine. 2019;18(6):4420-4426. https://doi.org/10.3892/etm.2019.8075
  22. Nagata Y, Takeuchi K, Yamamoto T, Ishikawa T, Kawabata T, Shimoyama Y, Wakabayashi T. Removal of the Medial Wall of the Cavernous Sinus for Functional Pituitary Adenomas: A Technical Report and Pathologic Significance. World Neurosurgery. 2019;126:53-58.  https://doi.org/10.1016/j.wneu.2019.02.134
  23. Nishioka H, Fukuhara N, Horiguchi K, Yamada S. Aggressive transsphenoidal resection of tumors invading the cavernous sinus in patients with acromegaly: predictive factors, strategies, and outcomes. Journal of Neurosurgery. 2014;121(3):505-510.  https://doi.org/10.3171/2014.3.JNS132214
  24. Koutourousiou M, Winstead WI. Endoscopic Endonasal Surgery for Remission of Cushing Disease Caused by Ectopic Intracavernous Macroadenoma: Case Report and Literature Review. World Neurosurgery. 2017;98:870.e5-870.e10.  https://doi.org/10.1016/j.wneu.2016.12.021
  25. Oldfield EH, Vortmeyer AO. Development of a histological pseudocapsule and its use as a surgical capsule in the excision of pituitary tumors. Journal of Neurosurgery. 2006;104(1):7-19.  https://doi.org/10.3171/jns.2006.104.1.7
  26. Monteith SJ, Starke RM, Jane Jr. JA, Oldfield EH. Use of the histological pseudocapsule in surgery for Cushing disease: rapid postoperative cortisol decline predicting complete tumor resection. Journal of Neurosurgery. 2012;116(4):721-727.  https://doi.org/10.3171/2011.12.JNS11886
  27. Watson JC, Shawker TH, Nieman LK, DeVroom HL, Doppman JL, Oldfield EH. Localization of pituitary adenomas by using intraoperative ultrasoound pituitary in patients with Cushing’s disease and no demonstrable tumor on magnetic resonance imaging. Journal of Neurosurgery. 1998;89(6):927-932.  https://doi.org/10.3171/jns.1998.89.6.0927
  28. George DH, Scheithauer BW, Kovacs K, Horvath E, Young Jr. WF, Lloyd RV, Meyer FB. Crooke’s cell adenoma of the pituitary: an aggressive variant of corticotroph adenoma. The American Journal of Surgical Pathology. 2003;27(10):1330-1336. https://doi.org/10.1097/00000478-200310000-00005
  29. Asa SL, Love S Ellison DW, edis LDN. Pituitary and suprasellar tumours. Greenfield’s Neuropathology. 8th ed. London: HodderArnold; 2008.
  30. Hui P, Xu X, Xu L, Hui G, Wu S, Lan Q. Expression of MMP14 in invasive pituitary adenomas: relationship to invasion and angiogenesis. International Journal of Clinical and Experimental Pathology. 2015;8(4):3556-3567.
  31. Burger PC, Vogel FSS. Region of the sella turcica. In: Surgical Pathology of the Nervous System and its Coverings. 4th ed. Philadelphia, PA Churchill Livingstone; 2002.
  32. Mete O, Ezzat S, Asa SL. Biomarkers of aggressive pituitary adenomas. Journal of Molecular Endocrinology. 2012;49(2):69-78.  https://doi.org/10.1530/JME-12-0113
  33. Rhoton ALJ. The Middle Cranial Base and Cavernous Sinus. Springer-Verlag/Wien. 2009.
  34. Jefferson G. The Invasive Adenomas of the Anterior Pituitary. Liverpool University Press. 1955.
  35. Carr SB, Kleinschmidt-DeMasters BK, Kerr JM, Kiseljak-Vassiliades K, Wierman ME, Lillehei KO. Negative surgical exploration in patients with Cushing’s disease: benefit of two-thirds gland resection on remission rate and a review of the literature. Journal of Neurosurgery. 2018;129(5):1260-1267. https://doi.org/10.3171/2017.5.JNS162901
  36. Yamada S, Fukuhara N, Nishioka H, Takeshita A, Inoshita N, Ito J, Takeuchi Y. Surgical Management and Outcomes in Patients with Cushing Disease with Negative Pituitary Magnetic Resonance Imaging. World Neurosurgery. 2012;77(3-4):525-532.  https://doi.org/10.1016/j.wneu.2011.06.033
  37. Pluta RM, Nieman L, Doppman JL, Watson JC, Tresser N, Katz DA, Oldfield EH. Extrapituitary Parasellar Microadenoma in Cushing’s Disease. The Journal of Clinical Endocrinology and Metabolism. 1999;84(8):2912-2923. https://doi.org/10.1210/jcem.84.8.5890
  38. Mason RB, Nieman LK, Doppman JL, Oldfield EH. Selective excision of adenomas originating in or extending into the pituitary stalk with preservation of pituitary function. Journal of Neurosurgery. 1997;87(3):343-351.  https://doi.org/10.3171/jns.1997.87.3.0343
  39. Hou L, Harshbarger T, Herrick MK, Tse V. Suprasellar adrenocorticotropic hormone-secreting ectopic pituitary adenoma: case report and literature Review. Neurosurgery. 2002;50(3):618-625.  https://doi.org/10.1097/00006123-200203000-00035
  40. Thomas T, Zender S, Terkamp C, Jaeckel E, Manns MP. Hypercortisolaemia due to ectopic adrenocorticotropic hormone secretion by a nasal paraganglioma: a case report and review of the literature. BMC Research Notes. 2013;6:331.  https://doi.org/10.1186/1756-0500-6-331
  41. Koizumi M, Usui T, Yamada S, Fujisawa I, Tsuru T, Nanba K, Hagiwara H, Kimura T, Tamanaha T, Tagami T, Naruse M, Shimatsu A. Successful treatment of Cushing’s disease caused by ectopic intracavernous microadenoma. Pituitary. 2011;14(3):295-298.  https://doi.org/10.1007/s11102-008-0156-9
  42. Trementino L, Arnaldi G, Appolloni G, Daidone V, Scaroni C, Casonato A, Boscaro M. Coagulopathy in Cushing’s Syndrome. Neuroendocrinology. 2010;92(suppl 1):55-59.  https://doi.org/10.1159/000314349
  43. Prete A, Corsello SM, Salvatori R. Current best practice in the management of patients after pituitary surgery. Therapeutic Advances in Endocrinology and Metabolism. 2017;8(3):33-48.  https://doi.org/10.1177/2042018816687240
  44. Loh JA, Verbalis JG. Diabetes insipidus as a complication after pituitary surgery. Nature Clinical Practice. Endocrinology and Metabolism. 2007;3(6):489-494.  https://doi.org/10.1038/ncpendmet0513
  45. Woodmansee WW, Carmichael J, Kelly D, Katznelson L, AACE Neuroendocrine and Pituitary Scientific Committee. American association of clinical endocrinologists and american college of endocrinology disease state clinical review: postoperative management following pituitary surgery. Endocrine Practice. 2015;21(7):832-838.  https://doi.org/10.4158/EP14541.DSCR
  46. Wang F, Zhou T, Wei S, Meng X, Zhang J, Hou Y, Sun G. Endoscopic endonasal transsphenoidal surgery of 1,166 pituitary adenomas. Surgical Endoscopy. 2015;29(6):1270-1280. https://doi.org/10.1007/s00464-014-3815-0
  47. Magro E, Graillon T, Lassave J, Castinetti F, Boissonneau S, Tabouret E, Fuentes S, Velly L, Gras R, Dufour H. Complications Related to the Endoscopic Endonasal Transsphenoidal Approach for Nonfunctioning Pituitary Macroadenomas in 300 Consecutive Patients. World Neurosurgery. 2016;89:442-453.  https://doi.org/10.1016/j.wneu.2016.02.059
  48. Cappabianca P, Cavallo LM, Colao A, de Divitiis E. Surgical complications associated with the endoscopic endonasal transsphenoidal approach for pituitary adenomas. Journal of Neurosurgery. 2002;97(2):293-298.  https://doi.org/10.3171/jns.2002.97.2.0293
  49. Koutourousiou M, Gardner PA, Fernandez-Miranda JC, Paluzzi A, Wang EW, Snyderman CH. Endoscopic endonasal surgery for giant pituitary adenomas: advantages and limitations. Journal of Neurosurgery. 2013;118(3):621-631.  https://doi.org/10.3171/2012.11.JNS121190
  50. Jang JH, Kim KH, Lee YM, Kim JS, Kim YZ. Surgical Results of Pure Endoscopic Endonasal Transsphenoidal Surgery for 331 Pituitary Adenomas: A 15-Year Experience from a Single Institution. World Neurosurgery. 2016;96:545-555.  https://doi.org/10.1016/j.wneu.2016.09.051
  51. Gondim JA, Almeida JP, Albuquerque LA, Schops M, Gomes E, Ferraz T, Sobreira W, Kretzmann MT. Endoscopic endonasal approach for pituitary adenoma: surgical complications in 301 patients. Pituitary. 2011;14(2):174-183.  https://doi.org/10.1007/s11102-010-0280-1
  52. Jain KC, Varma A, Mahapatra AK. Pituitary abscess: a series of six cases. British Journal of Neurosurgery. 1997;11(2):139-143.  https://doi.org/10.1080/02688699746492
  53. Ciric I, Ragin A, Baumgartner C, Pierce D. Complications of transsphenoidal surgery: results of a national survey, review of the literature, and personal experience. Neurosurgery. 1997;40(2):225-237.  https://doi.org/10.1097/00006123-199702000-00001
  54. Roelfsema F, Biermasz NR, Pereira AM. Clinical factors involved in the recurrence of pituitary adenomas after surgical remission: a structured review and meta-analysis. Pituitary. 2012;15(1):71-83.  https://doi.org/10.1007/s11102-011-0347-7
  55. Astaf’eva LI. The efficacy of desmopressin in the treatment of central diabetes insipidus after resection of chiasmo-sellar region tumors. Voprosy nejrohirurgii imeni N.N. Burdenko. 2017;81(4):61-69. (In Russ.). https://doi.org/10.17116/neiro201781461-69
  56. Cote DJ, Alzarea A, Acosta MA, Hulou MM, Huang KT, Almutairi H, Alharbi A, Zaidi HA, Algrani M, Alatawi A, Mekary RA, Smith TR. Predictors and Rates of Delayed Symptomatic Hyponatremia after Transsphenoidal Surgery: A Systematic Review [corrected]. World Neurosurgery. 2016;88:1-6.  https://doi.org/10.1016/j.wneu.2016.01.022
  57. Astaf’eva LI, Kutin MA, Mazerkina NA, Nepomnyashchiy VP, Popugaev KA, Kadashev BA, Sidneva YG, Strunina YV, Klochkova IS, Tserkovnaya DA, Kalinin PL, Aref’eva IA, Mochenova NN. The rate of hyponatremia in neurosurgical patients (comparison between the data from the Burdenko Neurosurgical Instutite and the literature) and recommendations for the diagnosis and treatment. Voprosy nejrohirurgii imeni N.N. Burdenko. 2016;80(1):57-70. (In Russ.). https://doi.org/10.17116/neiro201680157-70
  58. Clayton RN, Raskauskiene D, Reulen RC, Jones PW. Mortality and morbidity in Cushing’s disease over 50 years in Stoke-on-Trent, UK: audit and meta-analysis of literature. The Journal of Clinical Endocrinology and Metabolism. 2011;96(3):632-642.  https://doi.org/10.1210/jc.2010-1942
  59. Clayton RN. Mortality in Cushing’s disease. Neuroendocrinology. 2010;92(suppl 1):71-76.  https://doi.org/10.1159/000315813

Email Confirmation

An email was sent to test@gmail.com with a confirmation link. Follow the link from the letter to complete the registration on the site.

Email Confirmation

We use cооkies to improve the performance of the site. By staying on our site, you agree to the terms of use of cооkies. To view our Privacy and Cookie Policy, please. click here.