The site of the Media Sphera Publishers contains materials intended solely for healthcare professionals.
By closing this message, you confirm that you are a certified medical professional or a student of a medical educational institution.

Login
EN
+7 (495) 482-4118
+7 (495) 482-0604

  • © 1998-2025
+7 (495) 482-43-29
EN
All journals
Journal
Year
Year
Search result: 0

Oshorov A.V.

Burdenko Neurosurgical Center

Aleksandrova E.V.

Burdenko Neurosurgical Center

Muradyan K.R.

Burdenko Center of Neurosurgery

Sosnovskaya O.Yu.

Burdenko Center of Neurosurgery

Sokolova E.Yu.

Burdenko Neurosurgical Center

Savin I.A.

Burdenko Neurosurgical Center

Pupillometry as a method for monitoring of pupillary light reflex in ICU patients

Authors:

Oshorov A.V., Aleksandrova E.V., Muradyan K.R., Sosnovskaya O.Yu., Sokolova E.Yu., Savin I.A.

More about the authors

Journal: Burdenko's Journal of Neurosurgery. 2021;85(3): 117‑123

DOI: 10.17116/neiro202185031117

Views: 6131

Downloaded: 250

Download PDF (RU)
Download PDF
Contact the author
Table of contents

To cite this article:

Oshorov AV, Aleksandrova EV, Muradyan KR, Sosnovskaya OYu, Sokolova EYu, Savin IA. Pupillometry as a method for monitoring of pupillary light reflex in ICU patients. Burdenko's Journal of Neurosurgery. 2021;85(3):117‑123. (In Russ., In Engl.)
https://doi.org/10.17116/neiro202185031117

 
МСФ на ЯМ
Close metadata
Recommended articles:
Arti­ficial ventilation in patients with stroke: main resu­lts of the Russian multicenter obse­rvational clinical trial RETAS. S.S. Korsakov Journal of Neurology and Psychiatry. 2024;(8-2):5-13
Intracranial hype­rtension in hemo­rrhagic stroke: a single-center retrospective study. Russian Journal of Anesthesiology and Reanimatology. 2024;(6):23-29

This review is devoted to the modern method of monitoring of pupil diameter and reactivity in patients with acute brain injury. The authors present complete data on diagnostic and prognostic capabilities of automated infrared pupillometry, which should take its rightful place in comprehensive assessment of functional brain state in ICU patients. In authors’ opinion, clinical introduction of pupillometry will improve prediction of outcomes following acute brain injury and quality of neurological monitoring in patients with cerebral edema and intracranial hypertension.

Keywords:

pupil diameter
pupillary light reflex
cerebral herniation
cerebral edema
intracranial hypertension
multimodal monitoring

Authors:

Oshorov A.V.

Burdenko Neurosurgical Center

Aleksandrova E.V.

Burdenko Neurosurgical Center

Muradyan K.R.

Burdenko Center of Neurosurgery

Sosnovskaya O.Yu.

Burdenko Center of Neurosurgery

Sokolova E.Yu.

Burdenko Neurosurgical Center

Savin I.A.

Burdenko Neurosurgical Center

Received:

12.06.2020

Accepted:

19.03.2021

List of references:

  1. The Brain Trauma Foundation. The American Association of Neurological Surgeons. The Joint Section on Neurotrauma and Critical Care. Pupillary diameter and light reflex. Journal of Neurotrauma. 2000;17(6-7):583-590.  https://doi.org/10.1089/neu.2000.17.583
  2. Cecil S, Chen PM, Callaway SE, Rowland SM, Adler DE, Chen JW. Traumatic brain injury advanced multimodal neuromonitoring from theory to clinical practice. Critical Care Nurse. 2011;31(2):25-37.  https://doi.org/10.4037/ccn2010226
  3. Larson MD, Behrends M. Portable infrared pupillometry: A review. Anesthesia and Analgesia. 2015;120(6):1242-1253. https://doi.org/10.1213/ANE.0000000000000314
  4. Martínez-Ricarte F, Castro A, Poca MA, Sahuquillo J, Expósito L, Arribas M, Aparicio J. Infrared pupillometry. Basic principles and their application in the non-invasive monitoring of neurocritical patients. Neurología. 2013;28(1):41-51.  https://doi.org/10.1016/j.nrl.2010.07.028
  5. Murray GD, Butcher I, McHugh GS, Lu J, Mushkudiani NA, Maas AIR, Marmarou A, Steyerberg EW. Multivariable prognostic analysis in traumatic brain injury: Results from the IMPACT study. Journal of Neurotrauma. 2007;24(2):329-337.  https://doi.org/10.1089/neu.2006.0035
  6. Park JG, Moon CT, Park DS, Song SW. Clinical utility of an automated pupillometer in patients with acute brain lesion. Journal of Korean Neurosurgical Society. 2015;58(4):363-367.  https://doi.org/10.3340/jkns.2015.58.4.363
  7. Taylor WR, Chen JW, Meltzer H, Gennarelli TA, Kelbch C, Knowlton S, Richardson J, Lutch MJ, Farin A, Hults KN, Marshall LF. Quantitative pupillometry, a new technology: Normative data and preliminary observations in patients with acute head injury — Technical note. Journal of Neurosurgery. 2003;98(1 Suppl):205-213.  https://doi.org/10.3171/jns.2003.98.1.0205
  8. Oddo M, Crippa IA, Mehta S, Menon D, Payen JF, Taccone FS, Citerio G. Optimizing sedation in patients with acute brain injury. Critical Care. 2016;20(1):128.  https://doi.org/10.1186/s13054-016-1294-5
  9. Kelbsch C, Strasser T, Chen Y, Feigl B, Gamlin PD, Kardon R, Peters T, Roecklein KA, Steinhauer SR, Szabadi E, Zele AJ, Wilhelm H, Wilhelm BJ. Standards in pupillography. Frontiers in Neurology. 2019;10:129.  https://doi.org/10.3389/fneur.2019.00129
  10. Gray AT, Krejci ST, Larson MD. Neuromuscular blocking drugs do not alter the pupillary light reflex of anesthetized humans. Archives of Neurology. 1997;54(5):579-584.  https://doi.org/10.1001/archneur.1997.00550170055014
  11. Chen JW, Vakil-Gilani K, Williamson KL, Cecil S. Infrared pupillometry, the Neurological Pupil index and unilateral pupillary dilation after traumatic brain injury: implications for treatment paradigms. Journal of the Korean Physical Society. 2014;3(1):1-10.  https://doi.org/10.1186/2193-1801-3-548
  12. Vanderheyden BA, Buck BD. Management of Elevated Intracranial Pressure. Journal of Pharmacy Practice. 2002;15(2):167-185.  https://doi.org/10.1106/55K6-GR05-T1PW
  13. Ritter AM, Muizelaar JP, Barnes T, Choi S, Fatouros P, Ward J, Bullock MR. Brain stem blood flow, pupillary response, and outcome in patients with severe head injuries. Neurosurgery. 1999;44(5):941-948.  https://doi.org/10.1097/00006123-199905000-00005
  14. Manley GT, Larson MD. Infrared pupillometry during uncal herniation. Journal of Neurosurgical Anesthesiology. 2002;14(3):223-228.  https://doi.org/10.1097/00008506-200207000-00009
  15. Boev AN, Fountas KN, Karampelas I, Boev C, Machinis TG, Feltes C, Okosun I, Dimopoulos V, Troup C. Quantitative pupillometry: normative data in healthy pediatric volunteers. Journal of Neurosurgery. 2005;103(6 Suppl): 496-500.  https://doi.org/10.3171/ped.2005.103.6.0496
  16. Olson DWM, Stutzman S, Saju C, Wilson M, Zhao W, Aiyagari V. Interrater Reliability of Pupillary Assessments. Neurocritical Care. 2016;24(2): 251-257.  https://doi.org/10.1007/s12028-015-0182-1
  17. Zhao W, Stutzman S, DaiWai O, Saju C, Wilson M, Aiyagari V. Inter-device reliability of the NPi-100 pupillometer. Journal of Clinical Neuroscience. 2016;33:79-82.  https://doi.org/10.1016/j.jocn.2016.01.039
  18. Couret D, Boumaza D, Grisotto C, Triglia T, Pellegrini L, Ocquidant P, Bruder NJ, Velly LJ. Reliability of standard pupillometry practice in neurocritical care: An observational, double-blinded study. Critical Care. 2016;20(1):1-9.  https://doi.org/10.1186/s13054-016-1239-z
  19. Larson MD, Talke PO. Effect of dexmedetomidine, an alpha2-adrenoceptor agonist, on human pupillary reflexes during general anaesthesia. British Journal of Clinical Pharmacology. 2001;51(1):27-33.  https://doi.org/10.1046/j.1365-2125.2001.01311.x
  20. Boxer Wachler BS, Krueger RR. Agreement and repeatability of pupillometry using videokeratography and infrared devices. Journal of Cataract and Refractive Surgery. 2000;26(1):35-40.  https://doi.org/10.1016/s0886-3350(99)00331-4
  21. Fountas KN, Kapsalaki EZ, Machinis TG, Boev AN, Robinson JS, Troup EC. Clinical implications of quantitative infrared pupillometry in neurosurgical patients. Neurocritical Care. 2006;5(1):55-60.  https://doi.org/10.1385/NCC:5:1:55
  22. Behrends M, Niemann CU, Larson MD. Infrared pupillometry to detect the light reflex during cardiopulmonary resuscitation: A case series. Resuscitation. 2012;83(10):1223-1228. https://doi.org/10.1016/j.resuscitation.2012.05.013
  23. Kramer CL, Rabinstein AA, Wijdicks EF, Hocker SE. Neurologist versus machine: is the pupillometer better than the naked eye in detecting pupillary reactivity. Neurocritical Care. 2014;21(2):309-311.  https://doi.org/10.1007/s12028-014-9988-5
  24. Dhakal LP, Sen A, Stanko CM, Rawal B, Heckman MG, Hoyne JB, Dimberg EL, Freeman ML, Ng LK, Rabinstein AA, Freeman WD. Early Absent Pupillary Light Reflexes After Cardiac Arrest in Patients Treated with Therapeutic Hypothermia. Therapeutic Hypothermia and Temperature Management. 2016;6(3):116-121.  https://doi.org/10.1089/ther.2015.0035
  25. Jahns FP, Miroz JP, Messerer M, Daniel RT, Taccone FS, Eckert P, Oddo M. Quantitative pupillometry for the monitoring of intracranial hypertension in patients with severe traumatic brain injury. Critical Care. 2019;23(1):155.  https://doi.org/10.1186/s13054-019-2436-3
  26. Rivas JJ, Lobato RD, Sarabia R, Cordobés F, Cabrera A, Gomez P. Extradural hematoma: analysis of factors influencing the courses of 161 patients. Neurosurgery. 1988;23(1):44-51.  https://doi.org/10.1227/00006123-198807000-00010
  27. Papangelou A, Zink EK, Chang WW, Frattalone A, Gergen D, Gottschalk A, Geocadin RG. Automated Pupillometry and Detection of Clinical Transtentorial Brain Herniation: A Case Series. Military Medicine. 2018;183(1-2): 113-121.  https://doi.org/10.1093/milmed/usx018
  28. Chesnut RM, Gautille T, Blunt BA, Klauber MR, Marshall LE. The localizing value of asymmetry in pupillary size in severe head injury: relation to lesion type and location. Neurosurgery. 1994;34(5):840-845.  https://doi.org/10.1227/00006123-199405000-00008
  29. Delfino AE, Cortinez LI, Fierro CV, Muñoz HR. Propofol consumption and recovery times after bispectral index or cerebral state index guidance of anaesthesia. British Journal of Anaesthesia. 2009;103(2):255-259.  https://doi.org/10.1093/bja/aep138
  30. Emelifeonwu JA, Reid K, Rhodes JK, Myles L. Saved by the Pupillometer! — A role for pupillometry in the acute assessment of patients with traumatic brain injuries? Brain Injury. 2018;32(5):675-677.  https://doi.org/10.1080/02699052.2018.1429021
  31. Al-Obaidi SZ, Atem FD, Stutzman SE, Olson DM. Impact of Increased Intracranial Pressure on Pupillometry: A Replication Study. Critical Care Explorations. 2019;1(10):e0054. https://doi.org/10.1097/CCE.0000000000000054
  32. Chen JW, Gombart ZJ, Rogers S, Gardiner SK, Cecil S, Bullock RM. Pupillary reactivity as an early indicator of increased intracranial pressure: The introduction of the Neurological Pupil index. Surgical Neurology International. 2011;2:82.  https://doi.org/10.4103/2152-7806.82248
  33. Shirozu K, Setoguchi H, Tokuda K, Karashima Y, Ikeda M, Kubo M, Nakamura K, Hoka S. The effects of anesthetic agents on pupillary function during general anesthesia using the automated infrared quantitative pupillometer. Journal of Clinical Monitoring and Computing. 2017;31(2):291-296.  https://doi.org/10.1007/s10877-016-9839-3
  34. Hou RH, Scaife J, Freeman C, Langley RW, Szabadi E, Bradshaw CM. Relationship between sedation and pupillary function: comparison of diazepam and diphenhydramine. British Journal of Clinical Pharmacology. 2006;61(6):752-760.  https://doi.org/10.1111/j.1365-2125.2006.02632.x
  35. Larson MD. Mechanism of opioid-induced pupillary effects. Clinical Neurophysiology. 2008;119(6):1358-1364. https://doi.org/10.1016/j.clinph.2008.01.106
  36. Rollins MD, Feiner JR, Lee JM, Shah S, Larson M. Pupillary effects of high-dose opioid quantified with infrared pupillometry. Anesthesiology. 2014;121(5):1037-1044. https://doi.org/10.1097/ALN.0000000000000384
  37. Ong C, Hutch M, Barra M, Kim A, Zafar S, Smirnakis S. Effects of Osmotic Therapy on Pupil Reactivity: Quantification Using Pupillometry in Critically Ill Neurologic Patients. Neurocritical Care. 2019;30(2):307-315.  https://doi.org/10.1007/s12028-018-0620-y
  38. McNett M, Moran C, Grimm D, Gianakis A. Pupillometry Trends in the Setting of Increased Intracranial Pressure. The Journal of Neuroscience Nursing. 2018;50(6):357-361.  https://doi.org/10.1097/JNN.0000000000000401

Close metadata

Contact the author
Email
Message
The publishing house "Media Sphere" does not provide treatment services, does not give recommendations on contacting medical institutions and specific specialists, on the prescription of medicines and dietary supplements.

Email Confirmation

An email was sent to test@gmail.com with a confirmation link. Follow the link from the letter to complete the registration on the site.

Email Confirmation

Contact us
If you have any questions, complaints or suggestions, please use this feedback form.
Email
Message
The publishing house "Media Sphere" does not provide treatment services, does not give recommendations on contacting medical institutions and specific specialists, on the prescription of medicines and dietary supplements.
Submit Application

You can become an author of one of our magazines, send a request and we will consider it in during the day.

Name
Phone
E-mail
Message
Login
Registration
E-mail
Password
Forgot Password?

Log in to the site using your account in one of the services

Password recovery
E-mail
Login
Register

We use cооkies to improve the performance of the site. By staying on our site, you agree to the terms of use of cооkies. To view our Privacy and Cookie Policy, please. click here.