Preliminary results of chronic intrathecal therapy in treatment of spastic syndromes of various etiologies

Dekopov A.V.

FGBU "NII neĭrokhirurgii im. N.N. Burdenko" RAMN, Moskva

Shabalov V.A.

FGBU "NII neĭrokhirurgii im. N.N. Burdenko" RAMN, Moskva

Tomskiĭ A.A.

FGBU "NII neĭrokhirurgii im. N.N. Burdenko" RAMN, Moskva

Gaevyi I.O.

Burdenko Neurosurgical Institute, Moscow, Russia

Salova E.M.

FGBU "NII neĭrokhirurgii im. N.N. Burdenko" RAMN, Moskva

Preliminary results of chronic intrathecal therapy in treatment of spastic syndromes of various etiologies

Authors:

Dekopov A.V., Shabalov V.A., Tomskiĭ A.A., Gaevyi I.O., Salova E.M.

More about the authors

Journal: Burdenko's Journal of Neurosurgery. 2015;79(3): 27‑33

DOI: 10.17116/neiro201579327-33

Downloaded: 19

To cite this article:

Dekopov AV, Shabalov VA, Tomskiĭ AA, Gaevyi IO, Salova EM. Preliminary results of chronic intrathecal therapy in treatment of spastic syndromes of various etiologies. Burdenko's Journal of Neurosurgery. 2015;79(3):27‑33. (In Russ., In Engl.)
https://doi.org/10.17116/neiro201579327-33

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Objective. To estimate the effectiveness of the chronic intrathecal baclofen infusion (ITB) for the treatment of botuloresistant spastic disorders. Material and methods. ITB have been performed in 15 cases of spastic disorders. In 8 cases spasticity was the result of cerebral palsy, 5 — spinal cord injure, 1 — cerebral injure, 1 — pyogenic spinal epiduritis. The results of surgical treatment were estimated with the Ashworth, GMFM-88 and Arens scales. These data have been exposed statistically analysis. Results. Significantly decrease of spasticity have been revealed in most cases: from 4.26±0.7 points before the operation to 1.8±0.67 points after the operation (p<0.004). In 8 cases we have observed improvement in motor functions. Conclusion. ITB is an effective procedure which leads to decreasing of spasticity, incree of movement volume and improvement in motor functions in patients with spastic disorders.

Keywords:

spasticity

chronic intrathecal therapy

baclofen pump

Authors:

Dekopov A.V.

FGBU "NII neĭrokhirurgii im. N.N. Burdenko" RAMN, Moskva

Shabalov V.A.

FGBU "NII neĭrokhirurgii im. N.N. Burdenko" RAMN, Moskva

Tomskiĭ A.A.

FGBU "NII neĭrokhirurgii im. N.N. Burdenko" RAMN, Moskva

Gaevyi I.O.

Burdenko Neurosurgical Institute, Moscow, Russia

Salova E.M.

FGBU "NII neĭrokhirurgii im. N.N. Burdenko" RAMN, Moskva

List of references:

Dekopov A.V., Shabalov V.A., Tomskiy A.A.. Differentiated approach to surgical treatment of spasticity in CP patients. In the book: Proceedings of the V congress of neurosurgeons. Ufa: 2009;359-360. In Russian.
Shabalov V.A., Dekopov A.V., Tomskiy A.A., Troshina E.M. Differentiated approach to neurosurgical treatment of locomotor pathology in cerebral palsy. Detskaya i podrostkovaya reabilitatsiya. 2008;2(11):5-11. In Russian.
W. Birkmayer (Ed.). Spasticity - a topical survey. Vienna. 1971.
Bobath K. Die Neuropathologie der zerebralen Kinderlahmung. Wien Med Wochenschr. 1966;116:736-741.
Fazano V, Broggi G. Surgical treatment of spasticity in cerebral palsy. Childs Brain. 1978;4:289-305.
Peacock W. Functional outcomes following selective posterior rhyzotomy in children with cerebral palsy. J Neurosurgery. 1991;74:380-385.
Decq F, Shin M. Surgery in the Peripheral Nerves for Lower Limb Spasticity. Operative Techniques in Neurosurgery. 2004;7(Issue 3):136-146.
Pinter M. Epidural electrical stimulation of posterior structures of the human lumbosacral cord: control of spasticity. Spinal cord. 2000;38(9):524-531.
Dekopov A.V., Shabalov V.A., Tomskiy A.A., Isagulyan E.D., Salova E.M. Chronic electrical stimulation of the spinal medulla in the treatment of cerebral and spinal spasticity. Rossiyskiy neyrokhirurgicheskiy zhurnal im
Penn RD, Kroin JS. Intrathecal baclofen alleviates spinal cord spasticity. Lancet. 1984 May 12;1(8385):1078-1078.
Albright A. Continuous intrathecal baclofen infusion for spasticity of cerebral origin. JAMA. 1993;270:2475-2477.
Albright AL, Cervi A, Singletary J. Intra-thecal baclofen for spasticity in cerebral palsy. JAMA. 1991;265:1418-1422.
Murphy NA, Irwin MC, Hoff C. In-trathecal baclofen therapy in children with cerebral palsy: Efficacy and com-plications. Arch Phys Med Rehabil. 2002;83:1721-1725.
Flckiger B, Knecht H, Grossmann S, Felleiter P. Device-related complications of long-term intrathecal drug therapy via implanted pumps. Spinal Cord. 2008;46:639-643.
Green LB, Nelson VS. Death after acute withdrawal of intrathecal baclofen: Case report and literature review. Arch Phys Med Rehabil. 1999;80:1600-1604.
Coffey RJ, Edgar TS, Francisco GE, Graziani V, Meythaler JM, Ridgely PM, Sadiq SA, Turner MS. Abrupt withdrawal from intrathecal baclofen: Recognition and management of a potentially life-threat-ening syndrome. Arch Phys Med Rehabil 2002;83:735-741.
Shit JS, Lai LP. The impact of intrathecal baclofen on the natural history of scoliosis in cerebral palsy. J Pediatr Orthop. 2008 Sep;28(6):684-687.
Steinbok P, O’Donnell M. Baclofen in-fusion for spastic cerebral palsy. Clin Neurosurg. 2000;47:440-457.
Penn RD, Savoy SM, Corcos D, Latash M, Gottlieb G, Parke B, Kroin JS. Intrathecal baclofen for severe spinal spasticity. N Engl J Med. 1989;320:1517-1521.
Lazorthes Y, Sallerin-Caute B, Verdie JC, Bastide R, Carillo JP. Chronic intrathecal baclofen administration for control of severe spasticity. J Neurosurgery. 1990;(72):393-402.
Walker RH, Danisi FO. Intrathecal baclofen for dystonia: benefits and complications during six years of experience. Mov Disord. 2000 Nov;15(6):1242-1247.
Dario A, Scamoni C, Bono G, Ghezzi A. Zaffaroni M: Functional improvement in patients with severe spinal spasticity treated with chronic intrathecal baclofen infusion. Functional Neurology. 2001;(16):4:311-315.
Steers WD, Meythaler JM. Effects of acute bolus and chronic continuous intrathecal baclofen on genitourinary dysfunction due to spinal cord pathology. J Urol. 1992;148(6):1849-1855.

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