Clinical-neurophysiological correlations in patients with depressive-delusional conditions

Iznak A.F.; Iznak E.V.; Abramova L.I.

doi:https://doi.org/10.17116/jnevro202112102146

Iznak A.F.

Mental Health Research Centre

ORCID: 0000-0003-3687-4319

Iznak E.V.

Mental Health Research Centre

ORCID: 0000-0003-1445-863X

Abramova L.I.

Mental Health Research Centre

Clinical-neurophysiological correlations in patients with depressive-delusional conditions

Authors:

Iznak A.F., Iznak E.V., Abramova L.I.

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Journal: S.S. Korsakov Journal of Neurology and Psychiatry. 2021;121(2): 46‑52

DOI: 10.17116/jnevro202112102146

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To cite this article:

Iznak AF, Iznak EV, Abramova LI. Clinical-neurophysiological correlations in patients with depressive-delusional conditions. S.S. Korsakov Journal of Neurology and Psychiatry. 2021;121(2):46‑52. (In Russ.)
https://doi.org/10.17116/jnevro202112102146

Подписка 2026 Журнал неврологии и психиатрии им. С.С. Корсакова (S.S. Korsakov Journal of Neurology and Psychiatry)

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OBJECTIVE

To analyze a complex of EEG parameters and quantitative clinical evaluations of depressive-delusional conditions in patients with schizoaffective disorder and to clarify their neurophysiological mechanisms.

MATERIAL AND METHODS

A study included 25 female patients, aged 22—40 years, with depressive-delusional conditions. Patients were assessed at baseline and after 4—6 weeks of treatment using HDRS and PANSS. EEG was recorded at each visit.

RESULTS

Significant correlations were revealed between the values of pre-treatment background EEG spectral power in narrow frequency bands and quantitative pre-treatment and post-treatment scores of patient’s clinical conditions.

CONCLUSION

The results allow clarifying the brain mechanisms of depressive-delusional disorders and reveal possible EEG-predictors of therapeutic response in its treatment.

Keywords:

schizoaffective disorder

depressive-delusional conditions

quantitative EEG

Authors:

Iznak A.F.

Mental Health Research Centre

ORCID: 0000-0003-3687-4319

Iznak E.V.

Mental Health Research Centre

ORCID: 0000-0003-1445-863X

Abramova L.I.

Mental Health Research Centre

Received:

27.05.2020

Accepted:

14.07.2020

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References:

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