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Bogdanova M.D.

Lomonosov Moscow State University, Moscow, Russia;
Sechenov First Moscow State Medical University, Moscow, Russia

Mikadze Iu.V.

Moskovskiĭ gosudarstvennyĭ universitet im. M.V. Lomonosova

Bembeeva R.Ts.

Pirogov Russian National Research Medical University, Moscow

Volkova E.Ju.

Rossiĭskaja detskaja klinicheskaja bolnitsa Minzdrava RF, Moskva

Methodological issues of cognitive impairment studies in pediatric multiple sclerosis patients

Authors:

Bogdanova M.D., Mikadze Iu.V., Bembeeva R.Ts., Volkova E.Ju.

More about the authors

Journal: S.S. Korsakov Journal of Neurology and Psychiatry. 2019;119(9): 105‑111

DOI: 10.17116/jnevro2019119091105

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Table of contents

METHODOLOGICAL ISSUES OF COGNITIVE IMPAIRMENT STUDIES IN PEDIATRIC MULTIPLE SCLEROSIS PATIENTS
METHODOLOGICAL ISSUES OF COGNITIVE IMPAIRMENT STUDIES IN PEDIATRIC MULTIPLE SCLEROSIS PATIENTS

To cite this article:

Bogdanova MD, Mikadze IuV, Bembeeva RTs, Volkova EJu. Methodological issues of cognitive impairment studies in pediatric multiple sclerosis patients. S.S. Korsakov Journal of Neurology and Psychiatry. 2019;119(9):105‑111. (In Russ.)
https://doi.org/10.17116/jnevro2019119091105

Подписка 2026 Журнал неврологии и психиатрии им. С.С. Корсакова (S.S. Korsakov Journal of Neurology and Psychiatry)
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Abstract:

The article provides a review of the characteristics of cognitive impairment in multiple sclerosis (MS) and methods for its assessment in children. The features of the most frequently used neuropsychological batteries, with consideration of specifics of cognitive impairment in MS, and data on assessment of a state of cognitive functions obtained using neuropsychological tests are presented. The authors also discuss the issue of a long-term impact of the disease on a state of cognitive functions. Clinical factors, which can lead to cognitive impairment (type of multiple sclerosis, age at manifestation, number of relapses), are described.

Keywords:

multiple sclerosis in children
pediatric multiple sclerosis
cognitive impairment
neuropsychological assessment
neuropsychological batteries

Authors:

Bogdanova M.D.

Lomonosov Moscow State University, Moscow, Russia;
Sechenov First Moscow State Medical University, Moscow, Russia

Mikadze Iu.V.

Moskovskiĭ gosudarstvennyĭ universitet im. M.V. Lomonosova

Bembeeva R.Ts.

Pirogov Russian National Research Medical University, Moscow

Volkova E.Ju.

Rossiĭskaja detskaja klinicheskaja bolnitsa Minzdrava RF, Moskva

Close metadata

References:

  1. Amato M, Zipoli V, Goretti B, Portaccio E, De Caro M, Ricchiuti L, Siracusa G, Masini M, Sorbi S, Trojano M. Benign multiple sclerosis: cognitive, psychological and social aspects in a clinical cohort. Journal of Neurology. 2006;253:1054-1059. https://doi.org/10.1007/s00415-006-0161-8
  2. Benedict R, Zivadinov R. Risk factors for and management of cognitive disfunction in multiple sclerosis. Nature Reviews Neurology. 2011;7(6):382-342. https://doi.org/10.1038/nrneurol.2011.61
  3. Amato M, Goretti, B, Ghezzi, A, Lori S, Zipoli V, Portaccio E, Moiola L, Falautano M, De Caro M.F, Lopez M, Patti F, Vecchio R, Pozzilli C, Bianchi V, Roscio M, Comi G, Trojano M. Cognitive and psychosocial features of childhood and juvenile MS. Neurology. 2008;70(20):1891-1897. https://doi.org/10.1212/01.wnl.0000312276.23177.fa
  4. Julian L, Serafin D, Charvet L, Ackerson J, Benedict R, Braaten E, Brown T, O’Donnell E, Parrish J, Preston T, Zaccariello M, Belman A, Chitnis T, Gorman M, Ness J, Patterson M, Rodriguez M, Waubant E, Weinstock-Guttman B, Yeh A, Krupp LB. Cognitive impairment occurs in children and adolescents with multiple sclerosis: Results from a United States network. Journal of Child Neurology. 2013;28(1):102-107. https://doi.org/10.1177/0883073812464816
  5. MacAllister W, Belman A, Milazzo M, Weisbrot D, Christodoulou C, Scherl W, Preston T, Cianculli C, Krupp L. Cognitive functioning in children and adolescents with multiple sclerosis. Neurology. 2005;64(8):1422-1425. https://doi.org/10.1212/01.WNL.0000158474.24191.BC
  6. Rao S, Leo G, Bernardin L, Unverzagt F. Cognitive dysfunction in multiple sclerosis. I. Frequency, patterns, and prediction. Neurology. 1991;41(5):685-691. https://doi.org/10.1212/WNL.41.5.685
  7. Sepulcre J, Vanotti S, Hernandez R, Sandoval G, Ca´ceres F, Garcea O, Villoslada P. Cognitive impairment in patients with multiple sclerosis using the brief repeatable battery-neuropsychology test. Multiple Sclerosis. 2006;12:187-195. https://doi.org/10.1191/1352458506ms1258oa
  8. Boringa J, Lazeron R, Reuling I, Ade`r HJ, Pfennings L, Lindeboom J, de Sonneville L, Kalkers N, Polman C. The brief repeatable battery of neuropsychological tests: normative values allow application in multiple sclerosis clinical practice. Multiple Sclerosis. 2001;7:263-267. https://doi.org/10.1177/135245850100700409
  9. Scherer P, Baum K, Bauer H, G€ohler H, Miltenburger C. Normalization of the brief repeatable battery of neuropsychological tests (BRB-N) for German-speaking regions. Application in relapsing-remitting and secondary progressive multiple sclerosis patients. Nervenarzt. 2004;75:984-990. https://doi.org/10.1007/s00115-004-1729-0
  10. Benedict R, Fischer J, Archibald C, Arnett P, Beatty W, Bobholz J, Chelune G, Fisk J, Langdon D, Caruso L, Foley F, LaRocca N, Vowels L, Weinstein A, DeLuca J, Rao S, Munschauer F. Minimal neuropsychological assessment of MS patients: a consensus approach. Clinical Neuropsychology. 2002;16:381-397. https://doi.org/10.1076/clin.16.3.381.13859
  11. Benedict R, Cookfair D, Gavett R, Gunther M, Munschauer F, Garg N, Weinstock-Guttman B. Validity of the minimal assessment of cognitive function in multiple sclerosis (MACFIMS). Journal of International Neuropsychological Society. 2006;12(4):549-558. https://doi.org/10.1017/s1355617706060723
  12. Parmenter B, Testa S, Schretlen D, Weinstock-Guttman B, Benedict R. The utility of regression-based norms in interpreting the minimal assessment of cognitive function in multiple sclerosis (MACFIMS). Journal of International Neuropsychological Society. 2010;16(1):6-16. https://doi.org/10.1017/S1355617709990750
  13. Strober L, Englert J, Munschauer F, Weinstock-Guttman B, Rao S, Benedict R. Sensitivity of conventional memory tests in multiple sclerosis: comparing the Rao Brief Repeatable Neuropsychological Battery and the Minimal Assessment of Cognitive Function in MS. Multiple Sclerosis. 2009;15(9):1077-1084. https://doi.org/10.1177/1352458509106615
  14. Langdon D, Amato M, Boringa J, Brochet B, Foley F, Fredrikson S, Hämäläinen P, Hartung H, Krupp L, Penner I, Reder A, Benedict R. Recommendations for a brief international cognitive assessment for multiple sclerosis (BICAMS). Multiple Sclerosis. 2012:18:891-898. https://doi.org/10.1177/1352458511431076
  15. Charvet LE, Shaw M, Frontario A, Langdon D, Krupp LB. Cognitive impairment in pediatric-onset multiple sclerosis is detected by the Brief International Cognitive Assessment for Multiple Sclerosis and computerized cognitive testing. Multiple Sclerosis. 2018;24(4):512-519. https://doi.org/10.1177/1352458517701588
  16. Portaccio E, Goretti, B, Lori S, Zipoli V, Centorrino S, Ghezzi A, Patti F, Bianchi V, Comi G, Trojano M, Amato M. The brief neuropsychological battery for children: A screening tool for cognitive impairment in childhood and juvenile multiple sclerosis. Multiple Sclerosis. 2009;15(5):620-626. https://doi.org/10.1177/1352458508101950
  17. Amato M, Langdon D, Montalban X, Benedict R, DeLuca J, Krupp L, Thompson A, Comi G. Treatment of cognitive impairment in multiple sclerosis: position paper. Journal of Neurology. 2013;260:1452-1468. https://doi.org/10.1007/s00415-012-6678-0
  18. Bobholz J, Rao S. Cognitive dysfunction in multiple sclerosis: a review of recent developments. Current Opinion in Neurology. 2003;16:283-288. https://doi.org/10.1097/00019052-200306000-00006
  19. Blaschek A, Storm van’s Gravesande K, Heinen F, Pritsch M, Mall V, Calabrese P. Neuropsychological aspects of childhood multiple sclerosis: An overview. Neuropediatrics. 2012;43:176-183. https://doi.org/10.1055/s-0032-1315429
  20. MacAllister W, Christodoulou C, Milazzo M, Preston T, Serafin D, Krupp L, Harder L. Pediatric multiple sclerosis: What we know and where are we headed? Child Neuropsychology. 2013;19(1):1-22. https://doi.org/10.1080/09297049.2011.639758
  21. Suppiej A, Cainelli E. Cognitive dysfunction in pediatric multiple sclerosis. Neuropsychiatric Disease and Treatment. 2014;10:1385-1392. https://doi.org/10.2147/NDT
  22. Pasto L, Portaccio E, Goretti B, Ghezzi A, Lori S, Hakiki B, Giannini M, Righini I, Razzolini L, Niccolai C, Moiola L, Falautano M, Simone M, Viterbo RG, Patti F, Cilia S, Pozzilli C, Bianchi V, Roscio M, Martinelli V, Comi G, Trojano M, Amato M. The cognitive reserve theory in the setting of pediatric-onset multiple sclerosis. Multiple Sclerosis Journal. 2016;22(13):1741-1749. https://doi.org/10.1177/1352458516629559
  23. Amato M, Goretti B, Ghezzi A, Lori S, Zipoli V, Moiola L, Falautano M, De Caro M, Viterbo R, Patti F, Vecchio R, Pozzilli C, Bianchi V, Roscio M, Martinelli V, Comi G, Portaccio E, Trojano M. Cognitive and psychosocial features in childhood and juvenile MS: Two-year follow-up. Neurology. 2010;75(13):1134-1140. https://doi.org/10.1212/WNL.0b013e3181f4d821
  24. Till C, Ghassemi R, Aubert-Broche B, Kerbrat A, Collins L, Narayanan S, Arnold D, Desrocher M, Sled J, Banwell B. MRI correlates of cognitive impairment in childhood-onset multiple sclerosis. Neuropsychology. 2011;25(3):319-332. https://doi.org/10.1037/a0022051
  25. Ross K, Schwebel D, Rinker J-II, Ness J, Ackerson, J. Neurocognitive sequelae in African American and Caucasian children with multiple sclerosis. Neurology. 2010;75(23):1134-1140. https://doi.org/10.1212/WNL.0b013e318200d7b9
  26. Charvet L, Cleary R, Vazquez K, Belman A, Krupp L. Social cognition in pediatric-onset multiple sclerosis (MS). Multiple Sclerosis. 2014;20(11):1478-1484. https://doi.org/10.1177/1352458514526942
  27. Smerbeck A, Parrish J, Serafin D, Yeh E, Weinstock-Guttman B, Hoogs M, Krupp L, Benedict R. Visual-cognitive processing deficits in pediatric multiple sclerosis. Multiple Sclerosis. 2011;17(4):449-456. https://doi.org/10.1177/1352458510391689
  28. Marin S, Banwell B, Till C. Cognitive trajectories in 4 patients with pediatric-onset multiple sclerosis: Serial evaluation over a decade. Journal of Child Neurology. 2013;28(12):1577-1586. https://doi.org/10.1177/0883073812465010
  29. Prakash R, Snook E, Lewis J, Motl R, Kramer A. Cognitive impairments in relapsing-remitting multiple sclerosis: A meta-analysis. Multiple Sclerosis. 2008;14(9):1250-1261. https://doi.org/10.1177/1352458508095004
  30. Charvet L, O’Donnell E, Belman A, Chitnis T, Ness J, Parrish J, Patterson M, Rodriguez M, Waubant E, Weinstock-Guttman B, Krupp L. Longitudinal evaluation of cognitive functioning in pediatric multiple sclerosis: Report from the US pediatric multiple sclerosis network. Multiple Sclerosis. 2014;20(11):1502-1510. https://doi.org/10.1177/1352458514527862
  31. Till C, Racine N, Araujo D, Narayanan S, Collins D, Aubert-Broche B, Arnold D, Banwell B. Changes in cognitive performance over a 1-year period in children and adolescents with multiple sclerosis. Neuropsychology. 2013;27(2):210-219. https://doi.org/10.1037/a0031665
  32. Banwell B, Ghezzi A, Bar-Or A, Mikaeloff T, Tardieu M. Multiple sclerosis in children: Clinical diagnosis, therapeutic strategies, and future directions. The Lancet Neurology. 2007;6(10):887-902. https://doi.org/10.1016/S1474-4422(07)70242-9
  33. Vleugels L, Lafosse C, Nunen A, Nachtergaele S, Ketelaer P, Charlier M, Vandenbussche E. Visuoperceptual impairment in multiple sclerosis patients diagnosed with neuropsychological tasks. Multiple Sclerosis. 2000;6:241-254. https://doi.org/10.1177/135245850000600406
  34. Ward J, Parkin A, Powell G, Squires E, Townshend J, Bradley V. False recognition of unfamiliar people: «Seeing film stars everywhere». Cognitive Neuropsychology. 1999;16:293-315. https://doi.org/10.1080/026432999380807
  35. Rao S, Leo L, Ellington L, Nauertz T, Bernandin L, Unverzagt F. Cognitive dysfunction in multiple sclerosis. II. Impact on employment and social functioning. Neurology. 1991;39:161-166. https://doi.org/10.1212/wnl.41.5.692
  36. Fuentes A, Collins D, Garcia-Lorenzo D, Sled J, Narayanan S, Arnold D, Banwell B, Till C. Memory performance and normalized regional brain volumes in patients with pediatric-onset multiple sclerosis. Journal of the International Neuropsychological Society. 2012;18(3):471-480. https://doi.org/10.1017/S1355617711001913
  37. Arnett P, Rao S, Grafman J, Bernardin L, Luchetta T, Binder J, Lobeck L. Executive functions in multiple sclerosis: An analysis of temporal ordering, semantic encoding, and planning abilities. Neuropsychology. 1997;11:535-544. https://doi.org/10.1037/0894-4105.11.4.535
  38. Penman M. Assessing the prevalence of cognitive impairment in multiple sclerosis: Implications for patient management. Axone. 1991;13(2):45-49.
  39. Banwell B, Anderson, P. The cognitive burden of multiple sclerosis in children. Neurology. 2005;64(5):891-894. https://doi.org/10.1212/01.WNL.0000152896.35341.51
  40. MacAllister W, Christodoulou C, Milazzo M, Krupp, L. Longitudinal neuropsychological assessment in pediatric multiple sclerosis. Developmental Neuropsychology. 2007;32(2):625-644. https://doi.org/10.1080/87565640701375872
  41. Deery B, Anderson V, Jacobs R, Neale J, Kornberg A. Childhood MS and ADEM: Investigation and comparison of neurocognitive features in children. Developmental Neuropsychology. 2010;35(5):506-521. https://doi.org/10.1080/87565641.2010.494921
  42. Till C, Ho C, Dudani A, Garcia-Lorenzo D, Collins D, Banwell, B. Magnetic resonance imaging predictors of executive functioning in patients with pediatric-onset multiple sclerosis. Archives of Clinical Neuropsychology. 2012;27(5):495-509. https://doi.org/10.1093/arclin/acs058
  43. Holland A, Graves D, Greenberg B, Harder L. Fatigue, emotional functioning, and executive dysfunction in pediatric multiple sclerosis. Child Neuropsychology. 2012;20(1):71-85. https://doi.org/10.1080/09297049.2012.748888
  44. Suchy Y. Executive functioning: Overview, assessment, and research issues for non- neuropsychologists. Annals of Behavioral Medicine. 2009;37(2):106-116. https://doi.org/10.1007/s12160-009-9097-4
  45. Amato M, Goretti B, Ghezzi A, Hakiki B, Niccolai C, Lori S. Neuropsychological features in childhood and juvenile multiple sclerosis: Five-year follow-up. Neurology. 2014;83(16):1432-1438. https://doi.org/10.1212/WNL.0000000000000885
  46. Amato M, Zipoli V, Portaccio E. Multiple sclerosis-related cognitive changes: a review of cross-sectional and longitudinal studies. Journal of the Neurology Science. 2006;245:41-46. https://doi.org/10.1016/j.jns.2005.08.019
  47. Achiron A, Barak Y. Cognitive impairment in probable multiple sclerosis. Journal of Neurology, Neurosurgery & Psychiatry. 2003;74:443-446. https://doi.org/10.1136/jnnp.74.4.443
  48. Zipoli V, Goretti B, Hakiki B, Siracusa G, Sorbi S, Portaccio E, Amato M. Cognitive impairment predicts conversion to multiple sclerosis in clinically isolated syndromes. Multiple Sclerosis. 2010;16:62-67. https://doi.org/10.1177/1352458509350311
  49. Amato M, Zipoli V, Goretti B, Portaccio E, De Caro M, Ricchiuti L, Siracusa G, Masini M, Sorbi S, Trojano M. Benign multiple sclerosis: cognitive, psychological and social aspects in a clinical cohort. Journal of Neurology. 2006;253:1054-1059. https://doi.org/10.1007/s00415-006-0161-8
  50. Hosseini B, Flora D, Banwell B, Till, C. Age of onset as a moderator of cognitive decline in pediatric-onset multiple sclerosis. Journal of the International Neuropsychological Society. 2014;20(8):796-804. https://doi.org/10.1017/S1355617714000642
  51. Ruano L, Branco M, Portaccio E, Goretti B, Niccolai C, Patti F, Chisari C, Gallo P, Grossi P, Ghezzi A, Roscio M, Mattioli F, Stampatori C, Simone M, Viterbo RG, Amato, MP. Patients with paediatric-onset multiple sclerosis are at higher risk of cognitive impairment in adulthood: An Italian collaborative study. Multiple Sclerosis Journal. 2018;24(9):1234-1242. https://doi.org/10.1177/1352458517717341
  52. Kalb R, Dilorenzo T, LaRocca N, Caruso L, Shawaryn M, Elkin R, Dince W. The impact of early-onset multiple sclerosis on cognitive and psychosocial indices. International Journal of MS Care. 1999;1(1):2-18. https://doi.org/10.7224/1537-2073-1.1.2
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