Objective. To study clinical characteristics and Doppler and laboratory parameters in women with headache and antiphospholipid syndrome. Material and methods. One hundred and forty-three women with headache (34 with migraine, 53 with tension type headache) and antiphospholipid syndrome and 56 healthy controls were examined. Results. Coagulogram and cerebral blood flow parameters were significantly different between controls and patients with headache and antiphoshpolipid syndrome. All women with antiphoshpolipid syndrome had changes in the thrombotic system and plasma. Blood flow parameters were higher in all patients with headache and antiphoshpolipid syndrome. Conclusion. Changes in laboratory and Doppler parameters depend on the clinical manifestations of cephalalgia, as well as the age of patients.