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Averchenkov D.M.

Bujanov Moscow City Clinical Hospital, Moscow, Russia

Bejsheeva M.T.

Bujanov Moscow City Clinical Hospital, Moscow, Russia;
Pirogov Russian National Research Medical University, Moscow, Russia

Ivakina E.D.

Pirogov Russian National Research Medical University, Moscow, Russia

Fominykh V.V.

FGBU "Nauchnyĭ tsentr nevrologii" RAMN, Moskva

Grazhdantseva L.Yu.

Bujanov Moscow City Clinical Hospital, Moscow, Russia

Ivashchenko R.A.

Gorodskaia klinicheskaia bol'nitsa #12

Arzumanian N.Sh.

Brylev L.V.

Nauchnyĭ tsentr nevrologii RAMN, Moskva

Guekht A.B.

Buyanov City Clinical Hospital;
Solovyov Scientific and Practical Psychoneurological Center;
Pirogov Russian National Research Medical University

Clinical case of levamisole-induced multifocal inflammatory leukoencephalopathy

Authors:

Averchenkov D.M., Bejsheeva M.T., Ivakina E.D., Fominykh V.V., Grazhdantseva L.Yu., Ivashchenko R.A., Arzumanian N.Sh., Brylev L.V., Guekht A.B.

More about the authors

Journal: S.S. Korsakov Journal of Neurology and Psychiatry. 2019;119(12): 106‑114

DOI: 10.17116/jnevro2019119121106

Read: 22854 times

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Table of contents

CLINICAL CASE OF LEVAMISOLE-INDUCED MULTIFOCAL INFLAMMATORY LEUKOENCEPHALOPATHY
CLINICAL CASE OF LEVAMISOLE-INDUCED MULTIFOCAL INFLAMMATORY LEUKOENCEPHALOPATHY

To cite this article:

Averchenkov DM, Bejsheeva MT, Ivakina ED, et al. . Clinical case of levamisole-induced multifocal inflammatory leukoencephalopathy. S.S. Korsakov Journal of Neurology and Psychiatry. 2019;119(12):106‑114. (In Russ.)
https://doi.org/10.17116/jnevro2019119121106

Подписка 2026 Журнал неврологии и психиатрии им. С.С. Корсакова (S.S. Korsakov Journal of Neurology and Psychiatry)
 
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Abstract:

Levamisole is an immunomodulatory drug which can trigger development of levamisole-induced multifocal inflammatory leukoencephalopathy (LIMIL) in patients treated for helminthic invasion, aphthous stomatitis, cancer, or cocaine users. LIMIL clinical case in patient 45 years old after single dose of levamisole (taken without any medical prescription) was described. We presented clinical history and clinical picture, MRI and laboratory data and treatment results during 1-year observation. According to similarity of LIMIL with acute disseminating encephalomyelitis or debut of multiple sclerosis and high frequency of levamisole usage in Russia (usually without medical prescription) LIMIL should be included in differential diagnosis in demyelinating disorders and treated according to current clinical recommendation.

Keywords:

leukoencephalopathy
levamisole
demyelinating disorders

Authors:

Averchenkov D.M.

Bujanov Moscow City Clinical Hospital, Moscow, Russia

Bejsheeva M.T.

Bujanov Moscow City Clinical Hospital, Moscow, Russia;
Pirogov Russian National Research Medical University, Moscow, Russia

Ivakina E.D.

Pirogov Russian National Research Medical University, Moscow, Russia

Fominykh V.V.

FGBU "Nauchnyĭ tsentr nevrologii" RAMN, Moskva

Grazhdantseva L.Yu.

Bujanov Moscow City Clinical Hospital, Moscow, Russia

Ivashchenko R.A.

Gorodskaia klinicheskaia bol'nitsa #12

Arzumanian N.Sh.

Brylev L.V.

Nauchnyĭ tsentr nevrologii RAMN, Moskva

Guekht A.B.

Buyanov City Clinical Hospital;
Solovyov Scientific and Practical Psychoneurological Center;
Pirogov Russian National Research Medical University

Close metadata

References:

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