Objective. The problem of detection and diagnosis of late forms of neurosyphilis remains relevant and to a large extent concerns the field of psychiatry. The autors study of professional activity of psychiatric hospital in this field with use of clinical and statistical data. Material and methods. The article presents modern statistical data on the detection of these forms of syphilis in psychiatric hospitals of the Moscow region in comparison with the indicators of 2008—2010. Results and conclusion. There were 2 clinical cases of late neurosyphilis identified and received specific therapy in a psychiatric hospital in 2016. It is concluded that there is a need for a cerebrospinal fluid analysis of all seropositive patients in psychiatric hospitals, including those who received treatment for various forms of syphilis.