The site of the Media Sphera Publishers contains materials intended solely for healthcare professionals.
By closing this message, you confirm that you are a certified medical professional or a student of a medical educational institution.

Login
EN
+7 (495) 482-4118
+7 (495) 482-4329
+8 800 250-18-12
  • (toll-free number for subscriptions)
    Mon-Fri from 10 a.m. to 6 p.m.

  • © 1998-2026
+7 (495) 482-43-29
EN
All journals
Journal
Year
Year
Search result: 0

Parfenov V.A.

Pervyĭ Moskovskiĭ gosudarstvennyĭ meditsinskiĭ universitet im. I.M. Sechenova, Moskva

Kamchatnov P.R.

Kafedra nevrologii i neĭrokhirurgii Rossiĭskogo gosudarstvennogo meditsinskogo universiteta im. N.I. Pirogova, Moskva

Vorob'eva O.V.

Kafedra nervnykh bolezneĭ fakul'teta poslevuzovskogo professional'nogo obrazovaniia vracheĭ

Gustov A.V.

Nizhegorodskaia gosudarstvennaia meditsinskaia akademiia

Glushkov K.S.

Semeynaya Policlinica №4, Korolev, Russia

Doronina O.B.

Novosibirsk State Medical University, Novosibirsk

Results of multicenter study of efficacy and safety of divaza in the treatment of the asthenic and mild to moderate cognitive disorders in elderly and senile subjects

Authors:

Parfenov V.A., Kamchatnov P.R., Vorob'eva O.V., Gustov A.V., Glushkov K.S., Doronina O.B.

More about the authors

Journal: S.S. Korsakov Journal of Neurology and Psychiatry. 2017;117(9): 43‑50

DOI: 10.17116/jnevro20171179143-50

Read: 9969 times

Download PDF (RU)
Contact the author
Table of contents

RESULTS OF MULTICENTER STUDY OF EFFICACY AND SAFETY OF DIVAZA IN THE TREATMENT OF THE ASTHENIC AND MILD TO MODERATE COGNITIVE DISORDERS IN ELDERLY AND SENILE SUBJECTS
RESULTS OF MULTICENTER STUDY OF EFFICACY AND SAFETY OF DIVAZA IN THE TREATMENT OF THE ASTHENIC AND MILD TO MODERATE COGNITIVE DISORDERS IN ELDERLY AND SENILE SUBJECTS

To cite this article:

Parfenov VA, Kamchatnov PR, Vorob'eva OV, Gustov AV, Glushkov KS, Doronina OB. Results of multicenter study of efficacy and safety of divaza in the treatment of the asthenic and mild to moderate cognitive disorders in elderly and senile subjects. S.S. Korsakov Journal of Neurology and Psychiatry. 2017;117(9):43‑50. (In Russ.)
https://doi.org/10.17116/jnevro20171179143-50

Подписка 2026 Журнал неврологии и психиатрии им. С.С. Корсакова (S.S. Korsakov Journal of Neurology and Psychiatry)
МСФ на ЯМ
Использование инфографики авторами научных работ
Close metadata
Recommended articles:
Cognitive impairment in asthenic diso­rders. S.S. Korsakov Journal of Neurology and Psychiatry. 2025;(3):27-32
Sleep diso­rders in imprinting diso­rders. S.S. Korsakov Journal of Neurology and Psychiatry. 2025;(5-2):75-80
The effect of sleep and other medi­cal and social factors on a woman’s reproductive function. S.S. Korsakov Journal of Neurology and Psychiatry. 2025;(5-2):81-86
The possibility of using neurotropic therapy in patients with persistent postural-perceptual dizziness. S.S. Korsakov Journal of Neurology and Psychiatry. 2025;(5):89-94
Modern concepts of sleep disturbances asso­ciated with mental diso­rders. S.S. Korsakov Journal of Neurology and Psychiatry. 2025;(6):7-12
Frailty in patients with atrial fibrillation: diagnosis, mana­gement, prevention and influence on prognosis. Russian Cardiology Bulletin. 2025;(1):5-12
A method of surgical treatment of elde­rly and senile patients burdened with combined extragenital pathology, with pelvic descension and uterine pathology. Russian Bulletin of Obstetrician-Gynecologist. 2025;(2):84-92
Asso­ciation of sleep diso­rders with APOE gene poly­morphisms among the resi­dents aged 25—64 years of the Novo­sibirsk city: WHO «MONICA psychosocial study». Russian Journal of Preventive Medi­cine. 2025;(5):75-81
Pecu­liarities of geni­tal prolapses in old age. Russian Bulletin of Obstetrician-Gynecologist. 2025;(3):41-49
Asso­ciation of adipokines and sleep diso­rders among the 25—44 year-old people. Russian Journal of Preventive Medi­cine. 2025;(8):41-47
Abstract:

Objective. To study the efficacy and safety of divasa in elderly and senile subjects with asthenic and mild to moderate cognitive disorders. Material and methods. The study included 126 patients with clinically significant asthenia and mild to moderate cognitive disorders. Asthenia was assessed with MFI-20, cognitive disorders with MMSE, clock drawing test and verbal association test. All patients were treated with divasa in dose 2 tablets 3 times a day. Results and conclusion. The efficacy and safety of divasa in asthenic and mild to moderate cognitive disorders in elderly and senile subjects were shown. There is a need for a multicenter placebo-controlled trial on the efficacy of divasa to treat cognitive and asthenic disorders in elderly patients.

Keywords:

asthenia
sleep disorders
mild cognitive disorders
moderate cognitive disorders
elderly and senile age
divaza

Authors:

Parfenov V.A.

Pervyĭ Moskovskiĭ gosudarstvennyĭ meditsinskiĭ universitet im. I.M. Sechenova, Moskva

Kamchatnov P.R.

Kafedra nevrologii i neĭrokhirurgii Rossiĭskogo gosudarstvennogo meditsinskogo universiteta im. N.I. Pirogova, Moskva

Vorob'eva O.V.

Kafedra nervnykh bolezneĭ fakul'teta poslevuzovskogo professional'nogo obrazovaniia vracheĭ

Gustov A.V.

Nizhegorodskaia gosudarstvennaia meditsinskaia akademiia

Glushkov K.S.

Semeynaya Policlinica №4, Korolev, Russia

Doronina O.B.

Novosibirsk State Medical University, Novosibirsk

Close metadata

References:

  1. World Economic and Social Survey. 2007: development in an aging world. New York: United Nations Department of Social and Economic Affairs; 2007 (Report No. E/2007/50/Rev.1ST/ESA/314). http://www.un.org/en/development/desa/policy/wess/wess_archive/2007wess.pdf
  2. Crimmins EM, Beltran-Sanchez H. Mortality and morbidity trends: is there compression of morbidity? J Gerontol B Psychol Sci Soc Sci. 2011;66(1):75-86. https://doi.org/10.1093/geronb/gbq088
  3. Chatterji S, Byles J, Cutler D, Seeman T, Verdes E. Health, functioning, and disability in older adults — present status and future implications. Lancet. 2015;385(9967):563-575. https://doi.org/10.1016/S0140-6736(14)61462-8
  4. Lebedeva VF, Semke VYa. Clinical peculiarities of mental disorders in elderly subects in general medical practice. Siber newsletter of psychiatry and narcology. 2005;3:81-84. (In Russ.).
  5. Morley JE, Vellas B, Van Kan GA, Anker SD, Bauer JM, Bernabei R, Cesari M, Chumlea WC, Doehner W, Evans J, Fried LP, Guralnik JM, Katz PR, Malmstrom TK, McCarter RJ, Robledo LMG, Rockwood K, von Haehling S, Vandewoude MF, Walston J. Frailty consensus: a call to action. J Amer Med Dir Ass. 2013;14(6):392-397. https://doi.org/10.1016/j.jamda.2013.03.022
  6. Ostapenko VS, Runikhina NК, Tkacheva ОN, Sharashkina NV. Instruments for sreening of senile asthenia syndrome in outpatient practice. Progress in gerontology. 2016;29(2):306-312. (In Russ.). http://pressa.ru/ru/reader/#/magazines/uspehi-gerontologii/issues/02-2016/pages/2/
  7. Parfenov VА, Zakharov VV, Preobrazhenskaya IS. Cognitive disorders. М.: Remedium; 2014. (In Russ.). http://www.remedium.ru/upload/iblock/23e/k_rasstroistva_sod.pdf
  8. World Health Organization. Dementia: A Public Health Priority. Geneva: WHO; 2012. http://www.who.int/mental_health/publications/dementia_report_2012/en/
  9. Reiman EM, Langbaum JBS, Tario PN. Alzheimer’s Prevention Initiative: a proposal to evaluate presymptomatic treatments as quickly as possible. Biomark Med. 2010;4:3-14. https://doi.org/10.2217/bmm.09.91
  10. Xu S, Xie B, Song M, Yu L, Wang L, An C, Zhu Q, Han K, Zhao X, Zhang R, Dong L, Chai N, Gao Y, Zhang Q, Wang X. High prevalence of mild cognitive impairment in the elderly: a community-based study in four cities of the Hebei province, China. Neuroepidemiology, 2014;42(2):123-130. https://doi.org/10.1159/000357374
  11. Gorelick PB. Blood Pressure and the Prevention of Cognitive Impairment. JAMA Neurol. 2014;71(10):1211-1213. https://doi.org/10.1001/jamaneurol.2014.2014
  12. Gorelick PB, Scuteri A, Black SE, Decarli C, Greenberg SM, Iadecola C, Launer LJ, Laurent S, Lopez OL, Nyenhuis D, Petersen RC, Schneider JA, Tzourio C, Arnett DK, Bennett DA, Chui HC, Higashida RT, Lindquist R, Nilsson PM, Roman GC, Sellke FW, Seshadri S; American Heart Association Stroke Council, Council on Epidemiology and Prevention, Council on Cardiovascular Nursing, Council on Cardiovascular Radiology and Intervention, and Council on Cardiovascular Surgery and Anesthesia. Vascular Contributions to Cognitive Impairment and Dementia: A Statement for Healthcare Professionals From the American Heart Association/American Stroke Association. Stroke. 2011;42(9):2672-2713. https://doi.org/10.1161/STR.0b013e3182299496
  13. Vorobyova OV, Fateyeva VV. Divaza in therapy of cerebrovascular disease: mechanism of action and therapeutic indications. Psychiatry. 2015(2):48-45. (In Russ.). http://www.psychiatry.ru/siteconst/userfiles//file/psy/psy66abs.pdf
  14. Epstein OI, Dygai АМ, Sherstoboyev ЕYu, Sergeyeva SА, Agafonov VI, Borovskaya ТG, Vetoshkina ТВ, Zuyeva ЕP, Zhdanov VV, Suslov NI, Fomina ТI, Goldberg ЕD. Experimental study of pharmacological effects of ultralow doses of antibodies ot endogeneous function regulators. Bul Exper Biol and med (Appendix 2). 2008;82-88. (In Russ.). http://www.iramn.ru/journal/bebm/2008/bbm08pr2.htm
  15. Fateyeva VV, Shumaher GI, Vorobyova ЕN, Khoreva МА, Voskanyan LR. Efficacy and safety of divaza in the treatment of subjects with chronic cerebral ischemia. Journal of neurology and psychiatry im. S.S. Korsakova. 2017;117(2):32-37. (In Russ.). https://doi.org/10.17116/jnevro20171172132-37
  16. Vorobyoba OV, Kamchatnov PE, Rachin AP. Efficacy and safety of a new neurotropic medicinal product Divaza in complex therapy of chronic cerebral ischemia. Effictive pharmacotherapy. 2014;31:42-48. (In Russ.). http://umedp.ru/magazines/effektivnaya_farmakoterapiya_nevrologiya_i_psikhiatriya_3_2014.html
  17. Mudrova OA, Schekolova NB, Borikov FA. Efficacy of divaza in early rehabilitation period post ischemic stroke. Journal of neurology and psychiatry im SS Korsakova. 2016;116(3):48-54. (In Russ.). https://doi.org/10.17116/jnevro20161163248-53
  18. Chukanova EI, Bogolepova AN, Chukanova AS. An experience of using divasa in the treatment of cerebrovascular insufficiency. Journal of neurology and psychiatry im. S.S. Korsakova. 2015;115(6):17-23. (In Russ.). https://doi.org/10.17116/jnevro20151156117-23
  19. Kamchatnov PR, Vorobyova OV, Rachin AP. Treatment of emotional and cognitive disorders in patients with chronic cerebral ischemia. Journal of neurology and psychiatry im. S.S. Korsakova. 2014;114(4):52-56. (In Russ.). https://www.mediasphera.ru/issues/zhurnal-nevrologii-i-psikhiatrii-im-s-s-korsakova/2014/4/downloads/ru/031997-7298201449
  20. ICH Harmonised Tripartite Guideline «General Considerations for Clinical Trials», E8, 1997. http://www.ich.org/products/guidelines/efficacy/efficacy-single/article/general-considerations-for-clinical-trials.html
  21. Smets EM, Garssen B, Bonke B, De Haes JC. The Multidimensional Fatigue Inventory (MFI) psychometric qualities of an instrument to assess fatigue. J Psychosom Res. 1995;39:315-325. https://doi.org/10.1016/0022-3999(94)00125-O
  22. Insomnia: current diagnostic and therapeutic approaches (ed. by prof. Levin YaI). М.: Medpraktika; 2005. (In Russ.). http://bono-esse.ru/blizzard/RPP/M/Psich/Insomnija/in_som.html
  23. Folstein MF, Folstein SE, McHugh PR. Mini-mental state: A practical method for grading the cognitive state of patients for the clinician. J Psychiatr Res. 1975;12:189-198. https://doi.org/10.1016/0022-3956(75)90026-6
  24. Zakharov VV, Yakhno NN. Cognitive disorders in elderly and senile age. Guidelines for physicians. M. 2005. (In Russ.). http://www.kremlin-neurology.ru/library/Zaharov_VV_Kogn-narush.pdf
  25. Brazier JE, Harper R, Jones NM, O’Cathain A, Thomas KJ, Usherwood T, Westlake L. Validating the SF-36 health survey questionnaire: new outcome measure for primary care. BMJ. 1992;305(6846):160-164. https://doi.org/10.1136/bmj.305.6846.160
  26. Busner J, Targum SD. The Clinical Global Impressions Scale. Applying a Research Tool in Clinical Practice. Psychiatry (Edgmont). 2007;4(7):28-37. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2880930/
  27. Poletaeyev AB, Alferova VV, Abrosimova АА. Natural neurotropic autoantibodies and nervous system pathologies. Neuroimmunology. 2003;1(1):11-17. (In Russ.). http://www.immunculus.ru/sites/immunculus.ru/files/Neiroimmunology%20%231%202003.pdf
  28. Stein TD, Fedynyshyn JP, Kalil RE. Circulating autoantibodies recognize and bind dying neurons following injury to the brain. J Neuropathol Exp Neurol. 2002;61(12):1100-1108. https://academic.oup.com/jnen/article/61/12/1100/2610066/Circulating-Autoantibodies-Recognize-and-Bind
  29. Jellinger KA. The enigma of vascular cognitive disorder and vascular dementia. Acta Neuropathol. 2007;113(4):349-388. https://doi.org/10.1007/s00401-006-0185-2
  30. Schneider JA, Arvanitakis Z, Bang W, Bennett DA. Mixed brain pathologies account for most dementia cases in community-dwelling older persons. Neurology. 2007;69:2197-2204. https://doi.org/10.1212/01.wnl.0000271090.28148.24
  31. Benedictus MR, van Harten AC, Leeuwis AE, Koene T, Scheltens P, Barkhof F, Prins ND, van der Flier WM. White Matter Hyperintensities Relate to Clinical Progression in Subjective Cognitive Decline. Stroke. 2015;46:2661-2664. https://doi.org/10.1002/acn3.343
Contact the author
Email
Message
The publishing house "Media Sphere" does not provide treatment services, does not give recommendations on contacting medical institutions and specific specialists, on the prescription of medicines and dietary supplements.

Email Confirmation

An email was sent to test@gmail.com with a confirmation link. Follow the link from the letter to complete the registration on the site.

Email Confirmation

Submit Application

You can become an author of one of our magazines, send a request and we will consider it in during the day.

Name
Phone
E-mail
Message
Login
Registration
E-mail
Password
Forgot Password?

Log in to the site using your account in one of the services

Password recovery
E-mail
Login
Register

We use cооkies to improve the performance of the site. By staying on our site, you agree to the terms of use of cооkies. To view our Privacy and Cookie Policy, please. click here.