Pathological redundancy of the motor act: modern concepts of the pathogenesis and approaches to the pharmacological treatment

Kudlatch A.I.; Shalkevich L.V.; Simonenko A.V.; Nalivko I.I.; Litvinova O.S.

doi:https://doi.org/10.17116/jnevro2017117111161-167

Kudlatch A.I.

Belarusian Medical Academy of Post-Graduate Education, Minsk, Republic of Belarus

Shalkevich L.V.

Belarusian Medical Academy of Postgraduate Education, Minsk, Belarus

Simonenko A.V.

City Clinical Child Psychiatric Dispensary, Minsk, Republic of Belarus

Nalivko I.I.

City Clinical Child Psychiatric Dispensary, Minsk, Republic of Belarus

Litvinova O.S.

City Clinical Child Psychiatric Dispensary, Minsk, Republic of Belarus

Pathological redundancy of the motor act: modern concepts of the pathogenesis and approaches to the pharmacological treatment

Authors:

Kudlatch A.I., Shalkevich L.V., Simonenko A.V., Nalivko I.I., Litvinova O.S.

More about the authors

Journal: S.S. Korsakov Journal of Neurology and Psychiatry. 2017;117(11): 161‑167

DOI: 10.17116/jnevro2017117111161-167

Read: 1600 times

Download PDF (RU)

Contact the author

Table of contents

To cite this article:

Kudlatch AI, Shalkevich LV, Simonenko AV, Nalivko II, Litvinova OS. Pathological redundancy of the motor act: modern concepts of the pathogenesis and approaches to the pharmacological treatment. S.S. Korsakov Journal of Neurology and Psychiatry. 2017;117(11):161‑167. (In Russ.)
https://doi.org/10.17116/jnevro2017117111161-167

Подписка 2026 Журнал неврологии и психиатрии им. С.С. Корсакова (S.S. Korsakov Journal of Neurology and Psychiatry)

Использование инфографики авторами научных работ

Close metadata

Abstract:

The authors present characteristics of pathogenetic mechanisms of pathological motor redundancy in children with neurological and psychoneurological pathologies examined in accordance with the original author’s concept. Pathological mechanisms of the development of motor redundancy, including obsessive movements, hyperkinesia, compulsions, motor and sensory stereotypes, taking into account a certain unity of mechanisms of their origin at the anatomical level, are described. The article demonstrates the differences in the formation of these pathological motor acts associated with changes in their function, i.e. neuromediation and neuromodulation, in certain structures of the central nervous system.

Keywords:

hyperkinetic syndrome

stereotypic movements

autostimulation

disruption of psychological development

hopantenic acid

Authors:

Kudlatch A.I.

Belarusian Medical Academy of Post-Graduate Education, Minsk, Republic of Belarus

Shalkevich L.V.

Belarusian Medical Academy of Postgraduate Education, Minsk, Belarus

Simonenko A.V.

City Clinical Child Psychiatric Dispensary, Minsk, Republic of Belarus

Nalivko I.I.

City Clinical Child Psychiatric Dispensary, Minsk, Republic of Belarus

Litvinova O.S.

City Clinical Child Psychiatric Dispensary, Minsk, Republic of Belarus

Close metadata

References:

Guzeva VI, Artemeva SB, Avakyan GN. Federalnoe rukovodstvo po detskoy nevrologii. M.: Spetsialnoe izdatelstvo meditsinskih knig; 2016. (In Russ.)
Lewis MH, Bodfish JW, Powell SB, Wiest B, Darling M, Golden RN. Plasma HVA in adults with mental retardation and stereotyped behavior: Biochemical evidence for a dopamine deficiency model. Am J Ment Retard. 1996;100(4):413-418. PMID:8718995
Roebel AM, MacLean WE Jr. Spontaneous eye-blinking and stereotyped behavior in older persons with mental retardation. Research in developmental disabilities. 2007;28(1):37-42. https://doi.org/10.1016/j.ridd.2005.10.004
Chao HT, Chen H, Samaco RC, Xue M, Chahrour M, Yoo J, Zoghbi HY. Dysfunction in GABA signalling mediates autism-like stereotypies and Rett syndrome phenotypes. Nature. 2010;468(7321):263-269. https://doi.org/10.1038/nature09582
Lewis M, Kim SJ. The pathophysiology of restricted repetitive behavior. Journal of neurodevelopmental disorders. 2009;1(2):114-132. https://doi.org/10.1007/s11689-009-9019-6
Krikova KV, Burd SG. Possible pathogenetic mechanisms of failure epilepsy treatment with carbamazepine. Epilepsia and paroxyzmal conditions. 2011;3(1):20-26. (In Russ.)
Mendelevich DM. Mental insanity in primary care physicians. Prakticheskaya Meditsina. 2011;48:29-36. (In Russ.)
Chukhutova GL. Stereotyped and self-injurious behavior in children with developmental disorders. Sovremennaya zarubezhnaya psikhologiya. 2013;4:92-117. (In Russ.)
Pierce K, Courchesne E. Evidence for a cerebellar role in reduced exploration and stereotyped behavior in autism. Biological Psychiatry. 2001;49(8): 655-664. PMID:11313033
Harris KM, Mahone EM, Singer HS. Nonautistic motor stereotypies: Clinical features and longitudinal follow-up. Pediatric Neurology. 2008;38(4):267-272. https://doi.org/10.1016/j.pediatrneurol.2007.12.008
Munkvad I, Pakkerberg H, Randrup A. Aminergic systems in basal ganglia associated with stereotyped hyperactive behavior and catalepsy. Brain Behavior and Evolution. 1968;1(2):89-100. https://doi.org/10.1159/000125496
Richman DM. Early intervention and prevention of self-injurious behaviour exhibited by young children with developmental disabilities. Journal of Intellectual Disability Research. 2008;52(1):3-17. https://doi.org/10.1111/j.1365-2788.2007.01027.x
Robinson PD, Schutz CK, Macciardi F, White BN, Holden JJA. Genetically determined low maternal serum dopamine B-hydroxylase levels and etiology of autism spectrum disorders. Am. J. Med. Genet. 2001;100:30-36. https://doi.org/10.1002/ajmg.1187
Shepperd G. Neirobiologiya. V 2 tomakh. M.: Mir; 1987; 1: 454; 2: 34-35, 173-176. (In Russ.)
Adrianov OS, Molodkina SN, Yamshchikova NG. Assotsiativnye sistemy mozga i ekstrapolyatsionnoe povedenie. M.: Meditsina; 1987. (In Russ.)
Bower JM, Kassel J. Variability in tactile projection patterns to cerebellar folia crus IIA of the Norway rat. Journal of comparative neurology. 1990;302(4):768-778. https://doi.org/10.1002/cne.903020409
Kates WR, Lanham DC, Singer HS. Frontal white matter reductions in healthy males with complex stereotypies. Pediatr Neurol. 2005;32(2):109-112. https://doi.org/10.1016/j.pediatrneurol.2004.09.005
Ponomarev VV. Hyperkinetic syndrome in neurological practice. Meditsinskie novosti. 2003;5:27-33. (In Russ.)
Dubovik KV. Stereotyped motions and repetitive behavior as symptoms of autism spectrum disorders. NeiroN’yus Psikhonevrologiya i neiropsikhiatriya. 2013;6(2):42-45. (In Russ.)
Evtushenko IS. Nootropics and neuroprotectors in modern clinical neuropharmacology. Mezhdunar. nevrol. zhurn. 2013;3(57):20-27. (In Russ.)
Zavadenko NN. Attention deficit hyperactivity disorder: diagnosis, pathogenesis, principles of treatment. VSP. 2014;4:48-53. (In Russ.)
Guzeva VI, Korostovtsev DD, Fomina MYu, Guzeva VV, Guzeva OV. The experience of hopantenic acid application in the syrup for the children, suffering from epilepsy with cognitive disorders and attention deficit and hyperactivity disorder. VSP. 2007;1:101-104. (In Russ.)
Balkanskaya SV, Studenikin VM, Kuzenkova LM, Maslova OI, Tomilova AYu. Nootrope medications for cognitive disorders correction in children with epilepsy. VSP. 2007;2:92-96. (In Russ.)
Karpova EA, Karabanov AV, Klyushnikov SA, Illarioshkin SN. Pantocalcin in Management and Rehabilitation of Patients with Neurodegenerative Disorders. Nervnye bolezni. 2016;4:28-32. (In Russ.)
Maslova OI, Studenikin VM, Chibisov IV, Balkanskaya SV, Kuzenkova LM. Efficacy of the use of Pantoham syrup 10% (hopantenic acid) for correction of cognitive disorders in children. VSP. 2004;4:52-57. (In Russ.)
Nikolaevskii VA, Slivkin DA, Belenova AS, Suslina SN, Fedosov PA, Velikanova NA, Slivkin AI. Comparative studying (experimental assessment) of nootropic activity of preparations on the basis of the pantogam and the succinic acid. Vestnik novykh meditsinskikh tekhnologii. Elektronnoe izdanie. 2013;1:121. (In Russ.)