In vitro effect of psychotropic drugs on the activity of leukocyte elastase

Androsova L.V.; Shmakova A.A.

doi:https://doi.org/

The site of the Media Sphera Publishers contains materials intended solely for healthcare professionals.
By closing this message, you confirm that you are a certified medical professional or a student of a medical educational institution.

Androsova L.V.

Scientific center of mental health, Moscow, Russia

Shmakova A.A.

FGBU "Nauchnyĭ tsentr psikhicheskogo zdorov'ia" RAMN, Moskva

In vitro effect of psychotropic drugs on the activity of leukocyte elastase

Authors:

Androsova L.V., Shmakova A.A.

More about the authors

Journal: S.S. Korsakov Journal of Neurology and Psychiatry. 2014;114(3): 55‑57

Read: 3178 times

Download PDF (RU)

Contact the author

Table of contents

To cite this article:

Androsova LV, Shmakova AA. In vitro effect of psychotropic drugs on the activity of leukocyte elastase. S.S. Korsakov Journal of Neurology and Psychiatry. 2014;114(3):55‑57. (In Russ.)

Подписка 2026 Журнал неврологии и психиатрии им. С.С. Корсакова (S.S. Korsakov Journal of Neurology and Psychiatry)

Использование инфографики авторами научных работ

Close metadata

Abstract:

Objective. To investigate the effect of the neuroleptic aminazine (chlorpromazine) and the antidepressant melipramine on the activity of leukocyte elastase (LE). Methods. The LE activity was measured on a spectrophotometer. Different doses of aminazine and melipramine in terms of therapeutic doses were added to the pooled blood serum sampled from 7 healthy people. Results. Aminazine and melipramine inhibited the LE activity. Conclusions. The dose-dependent inhibiting effect of aminazine and melipramine was shown.

Keywords:

leukocyte elastase

chlorpromazine