Objective. To study the efficacy and safety of artrosilene in the combination with piascledine in patients with low-back pain. Methods. Sixty patients, 42 women and 18 men (mean age 53,6±10,4 years) with chronic nonspecific low-back pain were treated with artrosilene (ketoprofen lysine salt) in the combination with the chondro protector piascledine (a mix of avocado and soybean oil extracts). Results. There the persistent decrease in the intensity of pain syndrome and severity of vertebral syndrome and improvement of quality of life. Conclusions. The drugs can be recommended for treatment of nonspecific low-back pain.