The A3243G mitochondrial DNA mutation in cerebral artery dissections

Kalashnikova L.A.; Dobrynina L.A.; Sakharova A.V.; Chaĭkovskaia R.P.; Nazarova M.A.; Mir-Kasimov M.F.; Patrusheva N.L.; Patrushev L.I.; Konovalov R.N.; Protskiy S.V.

Kalashnikova L.A.

Nauchnyĭ tsentr nevrologii RAMN, Uchrezhdenie RAN Institut bioorganicheskoĭ khimii, Moskva

Dobrynina L.A.

Nauchnyĭ tsentr nevrologii RAMN, Moskva

ORCID: 0000-0001-9929-2725

Sakharova A.V.

Nauchnyĭ tsentr nevrologii RAMN, Moskva

Chaĭkovskaia R.P.

Nauchnyĭ tsentr nevrologii RAMN, Moskva

Nazarova M.A.

Mir-Kasimov M.F.

Nauchnyĭ tsentr nevrologii RAMN, Moskva

Patrusheva N.L.

FGBU "Institut bioorganicheskoĭ khimii im. akad. M.M. Shemiakina i Iu.A. Ovchinnikova" RAN, Moskva

Patrushev L.I.

Nauchnyĭ tsentr serdechno-sosudistoĭ khirurgii im. A.N. Bakuleva RAMN, Moskva;
Institut bioorganicheskoĭ khimii im. M.M. Shemiakina i Iu.A. Ovchinnikova, Moskva

Konovalov R.N.

Nauchnyĭ tsentr nevrologii RAMN, Moskva

Protskiy S.V.

Research Center of Neurology, Moscow, Russia

The A3243G mitochondrial DNA mutation in cerebral artery dissections

Authors:

Kalashnikova L.A., Dobrynina L.A., Sakharova A.V., Chaĭkovskaia R.P., Nazarova M.A., Mir-Kasimov M.F., Patrusheva N.L., Patrushev L.I., Konovalov R.N., Protskiy S.V.

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Journal: S.S. Korsakov Journal of Neurology and Psychiatry. 2012;112(1): 84‑89

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To cite this article:

Kalashnikova LA, Dobrynina LA, Sakharova AV, et al. The A3243G mitochondrial DNA mutation in cerebral artery dissections. S.S. Korsakov Journal of Neurology and Psychiatry. 2012;112(1):84‑89. (In Russ.)

Подписка 2026 Журнал неврологии и психиатрии им. С.С. Корсакова (S.S. Korsakov Journal of Neurology and Psychiatry)

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Abstract:

Metabolic syndrome is a risk factor for acute and chronic cerebrovascular diseases. The development of oxidative stress promotes the progression of cerebral ischemia and treatment of the biochemical disturbances is needed. Use of antioxidants in patients with cerebrovascular diseases and metabolic syndrome reduce such symptoms as insulin resistance, hyperglyceridemia, hyperglycemia. The authors present results of a clinical study of mexidol in 40 patients, aged from 50 to 70 years, with chronic cerebrovascular pathology. Perspectives of using this group of drugs as universal neuroprotectors are discussed.

Keywords:

cerebral artery dissection

mitochondrial cytopathy

mitochondrial disease

A3243G mtDNA mutation

mitochondrial DNA

Authors:

Kalashnikova L.A.

Nauchnyĭ tsentr nevrologii RAMN, Uchrezhdenie RAN Institut bioorganicheskoĭ khimii, Moskva

Dobrynina L.A.

Nauchnyĭ tsentr nevrologii RAMN, Moskva

ORCID: 0000-0001-9929-2725

Sakharova A.V.

Nauchnyĭ tsentr nevrologii RAMN, Moskva

Chaĭkovskaia R.P.

Nauchnyĭ tsentr nevrologii RAMN, Moskva

Nazarova M.A.

Mir-Kasimov M.F.

Nauchnyĭ tsentr nevrologii RAMN, Moskva

Patrusheva N.L.

FGBU "Institut bioorganicheskoĭ khimii im. akad. M.M. Shemiakina i Iu.A. Ovchinnikova" RAN, Moskva

Patrushev L.I.

Nauchnyĭ tsentr serdechno-sosudistoĭ khirurgii im. A.N. Bakuleva RAMN, Moskva;
Institut bioorganicheskoĭ khimii im. M.M. Shemiakina i Iu.A. Ovchinnikova, Moskva

Konovalov R.N.

Nauchnyĭ tsentr nevrologii RAMN, Moskva

Protskiy S.V.

Research Center of Neurology, Moscow, Russia

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