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Iznak A.F.

Nauchnyĭ tsentr psikhicheskogo zdorov'ia RAMN

Iznak E.V.

Nauchnyĭ tsentr psikhicheskogo zdorov'ia RAMN

Sorokin S.A.

Dynamics and relationships of parameters of cognitive evoked potentials and sensorimotor reactions in the treatment of apathic depression

Authors:

Iznak A.F., Iznak E.V., Sorokin S.A.

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Journal: S.S. Korsakov Journal of Neurology and Psychiatry. 2011;111(9): 52‑57

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Table of contents

DYNAMICS AND RELATIONSHIPS OF PARAMETERS OF COGNITIVE EVOKED POTENTIALS AND SENSORIMOTOR REACTIONS IN THE TREATMENT OF APATHIC DEPRESSION
DYNAMICS AND RELATIONSHIPS OF PARAMETERS OF COGNITIVE EVOKED POTENTIALS AND SENSORIMOTOR REACTIONS IN THE TREATMENT OF APATHIC DEPRESSION

To cite this article:

Iznak AF, Iznak EV, Sorokin SA. Dynamics and relationships of parameters of cognitive evoked potentials and sensorimotor reactions in the treatment of apathic depression. S.S. Korsakov Journal of Neurology and Psychiatry. 2011;111(9):52‑57. (In Russ.)

Подписка 2026 Журнал неврологии и психиатрии им. С.С. Корсакова (S.S. Korsakov Journal of Neurology and Psychiatry)
МСФ на ЯМ
Использование инфографики авторами научных работ
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Abstract:

The aim of the study was to investigate the neurophysiologic bases of impairments of motor and some cognitive functions in apathic depression using neurophysiologic and psychophysiologic methods together with clinical assessment of patient's conditions in the dynamics of treatment. Latencies of main components of auditory cognitive evoked potentials (EP) as well as latencies of simple sensorimotor reaction and of two-alternative choice reaction to auditory stimuli have been analyzed. The significant decrease of mean values of the P3 component of auditory cognitive EP in comparison with baseline (before beginning of treatment) level has been noted in patients at the stage of pronounced clinical improvement while latencies of N1, P2 and N2 components have not changed significantly. The mean values of latencies of both simple sensorimotor reaction and of two-alternative choice reaction have been decreased as well. The peculiarities of correlations between clinical indices of depression severity and values of latencies of components of cognitive EP in left and right hemispheric leads in patients with apathic depression indicate the relationship of depression severity with impairment of functional state of the left hemisphere and with activation of the right hemisphere that is in good concordance with contemporary views on the dominant role of the right brain hemisphere in the pathogenesis of depression.

Keywords:

apathic depression
cognitive (event related) evoked potentials
sensorimotor reactions
interhemispheric relations

Authors:

Iznak A.F.

Nauchnyĭ tsentr psikhicheskogo zdorov'ia RAMN

Iznak E.V.

Nauchnyĭ tsentr psikhicheskogo zdorov'ia RAMN

Sorokin S.A.

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References:

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