Clinical significance of humoral compensatory reactions in the acute period of ischemic stroke

Alferova V.V.; Uzbekov M.G.; Misionzhnik É.Iu.; Gekht A.B.

doi:https://doi.org/

Alferova V.V.

Kafedra nevrologii i neĭrokhirurgii Rossiĭskogo gosudarstvennogo meditsinskogo universiteta, Moskva

Uzbekov M.G.

Moskovskiĭ NII psikhiatrii

Misionzhnik É.Iu.

Moskovskiĭ NII psikhiatrii

Gekht A.B.

Kafedra nevrologii i neĭrokhirurgii Rossiĭskogo gosudarstvennogo meditsinskogo universiteta, Moskva

SPIN RSCI: 7691-3288
Scopus AuthorID: 7003326363
ResearcherID: Y-6725-2018
ORCID: 0000-0002-1170-6127

Clinical significance of humoral compensatory reactions in the acute period of ischemic stroke

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Alferova V.V., Uzbekov M.G., Misionzhnik É.Iu., Gekht A.B.

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Journal: S.S. Korsakov Journal of Neurology and Psychiatry. 2011;111(8): 36‑40

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To cite this article:

Alferova VV, Uzbekov MG, Misionzhnik ÉIu, Gekht AB. Clinical significance of humoral compensatory reactions in the acute period of ischemic stroke. S.S. Korsakov Journal of Neurology and Psychiatry. 2011;111(8):36‑40. (In Russ.)

Подписка 2026 Журнал неврологии и психиатрии им. С.С. Корсакова (S.S. Korsakov Journal of Neurology and Psychiatry)

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Results of the international multicenter randomized, double-blind, placebo-controlled clinical trial for the evaluation of the efficacy and safety of the sequential therapy with ethylmethylhydroxypyridine succinate in patients in the acute and early recovery periods of ischemic stroke (MIR). S.S. Korsakov Journal of Neurology and Psychiatry. 2025;(8-2):40-53

Abstract:

To determine the clinical significance of humoral nonspecific reactions in the acute period of ischemic hemispheric stroke (IS), some biochemical and biophysical parameters have been studied in 30 patients (mean age 67±10 years). Platelet monoaminooxidase (MAO) activity, levels of middle-sized molecules (MM), malonic dialdehyde (MDA) and parameters of the functional state of serum albumin (the effective concentration and binding reserve of albumin) have been measured. Severity of neurological deficit and functional recovery of patients with IS was assessed with the NIHSS and the Barthel index. The control group included 17 age- and sex-matched healthy people (p<0,1). The significant changes in all biochemical and biophysical parameters were seen in patients compared to the control group (p<0,01). The increase in MAO activity in patients was associated with the enhancement of free-radical reactions MDA/MAO: rs=+0,62, p=0,0001. The elevation of acceptor capacity of albumin related to the enhancement of its detoxicating function was found in patients with the regression of neurological deficit. It has been assumed that some nonspecific humoral reactions play a pathogenetic role in the acute period of ischemic stroke.

Keywords:

acute period of ischemic stroke

platelet monoaminooxidase

malonic dialdehyde

middle-sized molecules

functional state of serum albumin

compensatory reactions

Authors:

Alferova V.V.

Kafedra nevrologii i neĭrokhirurgii Rossiĭskogo gosudarstvennogo meditsinskogo universiteta, Moskva

Uzbekov M.G.

Moskovskiĭ NII psikhiatrii

Misionzhnik É.Iu.

Moskovskiĭ NII psikhiatrii

Gekht A.B.

Kafedra nevrologii i neĭrokhirurgii Rossiĭskogo gosudarstvennogo meditsinskogo universiteta, Moskva

SPIN RSCI: 7691-3288
Scopus AuthorID: 7003326363
ResearcherID: Y-6725-2018
ORCID: 0000-0002-1170-6127

Close metadata

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