The state of the immune system in endogenous mental diseases with pronounced affective disorders

Zozulya S.A.

Scientific center of mental health, Moscow, Russia

Siriachenko T.M.

Kaleda V.G.

Nauchnyĭ tsentr psikhicheskogo zdorov'ia RAMN, Moskva

SPIN RSCI: 9035-3290
Scopus AuthorID: 56765570100
ResearcherID: K-5466-2013
ORCID: 0000-0002-1209-1443

Dupin A.M.

Omel'chenko M.A.

Otman I.N.

Scientific center of mental health, Moscow, Russia

Klyushnik T.P.

Scientific center of mental health, Moscow, Russia

The state of the immune system in endogenous mental diseases with pronounced affective disorders

Authors:

Zozulya S.A., Siriachenko T.M., Kaleda V.G., Dupin A.M., Omel'chenko M.A., Otman I.N., Klyushnik T.P.

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Journal: S.S. Korsakov Journal of Neurology and Psychiatry. 2011;111(12): 63‑67

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To cite this article:

Zozulya SA, Siriachenko TM, Kaleda VG, Dupin AM, Omel'chenko MA, Otman IN, Klyushnik TP. The state of the immune system in endogenous mental diseases with pronounced affective disorders. S.S. Korsakov Journal of Neurology and Psychiatry. 2011;111(12):63‑67. (In Russ.)

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Parameters of innate and adaptive immunity were studied in the blood serum of 180 patients, aged 15-25 years, with different endogenous mental diseases with depressive and mania disorders in the clinical picture (affective psychoses (29 patients), schizoaffective psychoses (106 patients) , slow-progressive schizophrenia (23 patients) and intermittent-progressive schizophrenia (22 patients)). The activation of innate immunity (the increase in the degranulation activity of leukocyte elastase (LE) and functional activity of alpha-1-proteinase inhibitor (α1-PI) were found in all the diseases. The increase in disease severity (from affective disorders to intermittent-progressive schizophrenia) was correlated with the significant elevation of LE activity. The LE activity did not depend on the polarity and severity of affective pathology in each diagnostic group. The mean levels of autoantibodies to the nerve growth factor and the myelin basic protein did not differ from the control values in all the groups of patients.

Keywords:

innate immunity

adaptive immunity

endogenous mental diseases

depressive and mania disorders

Authors:

Zozulya S.A.

Scientific center of mental health, Moscow, Russia

Siriachenko T.M.

Kaleda V.G.

Nauchnyĭ tsentr psikhicheskogo zdorov'ia RAMN, Moskva

SPIN RSCI: 9035-3290
Scopus AuthorID: 56765570100
ResearcherID: K-5466-2013
ORCID: 0000-0002-1209-1443

Dupin A.M.

Omel'chenko M.A.

Otman I.N.

Scientific center of mental health, Moscow, Russia

Klyushnik T.P.

Scientific center of mental health, Moscow, Russia

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