The state of the immune system in endogenous mental diseases with pronounced affective disorders

Zozulya S.A.; Siriachenko T.M.; Kaleda V.G.; Dupin A.M.; Omel'chenko M.A.; Otman I.N.; Klyushnik T.P.

doi:https://doi.org/

Zozulya S.A.

Scientific center of mental health, Moscow, Russia

Siriachenko T.M.

Kaleda V.G.

Nauchnyĭ tsentr psikhicheskogo zdorov'ia RAMN, Moskva

SPIN RSCI: 9035-3290
Scopus AuthorID: 56765570100
ResearcherID: K-5466-2013
ORCID: 0000-0002-1209-1443

Dupin A.M.

Omel'chenko M.A.

Otman I.N.

Scientific center of mental health, Moscow, Russia

Klyushnik T.P.

Scientific center of mental health, Moscow, Russia

The state of the immune system in endogenous mental diseases with pronounced affective disorders

Authors:

Zozulya S.A., Siriachenko T.M., Kaleda V.G., Dupin A.M., Omel'chenko M.A., Otman I.N., Klyushnik T.P.

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Journal: S.S. Korsakov Journal of Neurology and Psychiatry. 2011;111(12): 63‑67

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To cite this article:

Zozulya SA, Siriachenko TM, Kaleda VG, Dupin AM, Omel'chenko MA, Otman IN, Klyushnik TP. The state of the immune system in endogenous mental diseases with pronounced affective disorders. S.S. Korsakov Journal of Neurology and Psychiatry. 2011;111(12):63‑67. (In Russ.)

Подписка 2026 Журнал неврологии и психиатрии им. С.С. Корсакова (S.S. Korsakov Journal of Neurology and Psychiatry)

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Abstract:

Parameters of innate and adaptive immunity were studied in the blood serum of 180 patients, aged 15-25 years, with different endogenous mental diseases with depressive and mania disorders in the clinical picture (affective psychoses (29 patients), schizoaffective psychoses (106 patients) , slow-progressive schizophrenia (23 patients) and intermittent-progressive schizophrenia (22 patients)). The activation of innate immunity (the increase in the degranulation activity of leukocyte elastase (LE) and functional activity of alpha-1-proteinase inhibitor (α1-PI) were found in all the diseases. The increase in disease severity (from affective disorders to intermittent-progressive schizophrenia) was correlated with the significant elevation of LE activity. The LE activity did not depend on the polarity and severity of affective pathology in each diagnostic group. The mean levels of autoantibodies to the nerve growth factor and the myelin basic protein did not differ from the control values in all the groups of patients.

Keywords:

innate immunity

adaptive immunity

endogenous mental diseases

depressive and mania disorders

Authors:

Zozulya S.A.

Scientific center of mental health, Moscow, Russia

Siriachenko T.M.

Kaleda V.G.

Nauchnyĭ tsentr psikhicheskogo zdorov'ia RAMN, Moskva

SPIN RSCI: 9035-3290
Scopus AuthorID: 56765570100
ResearcherID: K-5466-2013
ORCID: 0000-0002-1209-1443

Dupin A.M.

Omel'chenko M.A.

Otman I.N.

Scientific center of mental health, Moscow, Russia

Klyushnik T.P.

Scientific center of mental health, Moscow, Russia

Close metadata

References:

Androsova L.V., Kaleda V.G., Barkhatova A.N. i dr. Vliyanie lecheniya pervogo pristupa endogennogo psikhoza u bol'nykh yunosheskogo vozrasta na produktsiyu interleikina-1β. Zhurn nevrol i psikhiat 2007; 9: 50-54.
Dotsenko V.L., Neshkova E.A., Yarovaya G.A. Vyyavlenie leikotsitarnoi elastazy cheloveka iz kompleksa s plazmennym α1-proteinaznym ingibitorom po ee enzimaticheskoi aktivnosti s sinteticheskim substratom. Voprosy med khimii 1994; 40: 3: 20-25.
Kaleda V.K., Klyushnik T.P., Sarmanova Z.V. i dr. Korrelyatsiya klinicheskikh i immunologicheskikh pokazatelei pri pervom pristupe yunosheskogo endogennogo psikhoza. Zhurn nevrol i psikhiat 2009; 109: 1: 16-19.
Klyushnik T.P., Krasnolobova S.A., Sarmanova Z.V. i dr. Vliyanie antitel k faktoru rosta nervov i syvorotochnomu al'buminu na razvitie i povedencheskie reaktsii myshei. Byull eksper biol i med 2004; 138: 7: 98-100.
Klyushnik T.P. Sostoyanie vrozhdennogo immuniteta pri narusheniyakh razvitiya nervnoi sistemy. Psikhiatriya 2007; 4: 79-85.
Klyushnik T.P., Siryachenko T.M., Sarmanova Z.V. i dr. Dinamika soderzhaniya antitel k neiroantigenam v syvorotke krovi bol'nykh shizofreniei v protsesse terapii. Zhurn nevrol i psikhiat 2008; 108: 8: 61-64.
Klyushnik T.P., Siryachenko T.M., Sarmanova Z.V. i dr. Immunologicheskie reaktsii pri razlichnykh formakh psikhicheskoi patologii. Zhurn nevrol i psikhiat 2009; 109: 4: 55-58.
Kolyaskina G.I. Immunologiya v psikhiatrii. V kn.: Rukovodstvo po psikhiatrii. T.1. Pod red. A.S. Tiganova. M: Meditsina 1999; 190-211.
Krupina N.A., Kryzhanovskii G.N. Nedostatochnost' dofaminergicheskoi nigrostriatnoi sistemy kak dizregulyatornyi mekhanizm dofamin-zavisimogo depressivnogo sindroma. Zhurn nevrol i psikhiat 2003; 103: 4: 42-47.
Kryzhanovskii N.N., Magaeva S.V., Makarov S.V. Neiroimmunologiya. M 1997.
Morozov S.G., Gribova I.E., Klyushnik T.P. i dr. Vliyanie povyshennogo urovnya antitel k osnovnomu belku mielina u samok myshei na postnatal'noe razvitie i povedencheskie reaktsii potomstva. Byull eksper biol i med 2007; 144: 10: 432-436.
Nartikova V.F., Paskhina T.S. Unifitsirovannyi metod opredeleniya aktivnosti α1-antitripsina i α2-makroglobulina v syvorotke krovi cheloveka. Voprosy med khimii 1977; 25: 4: 492-497.
Poletaev A.B., Morozov S.G., Kovalev I.E. Regulyatornaya metasistema (immunoneiroendokrinnaya regulyatsiya gomeostaza). M: Meditsina 2002; 27-50.
Sergienko N.S. Nevrologicheskie simptomy psikhicheskogo dizontogeneza detei rannego vozrasta: Avtoref. dis. … kand. med. nauk. M 1999.
Shcherbakova I.V. Osobennosti vrozhdennogo i priobretennogo immuniteta pri vysokom riske vozniknoveniya shizofrenii i v protsesse ee razvitiya: Avtoref. dis. … d-ra med. nauk. M 2006.
Shcherbakova I.V., Ciryachenko T.M., Mazaeva N.A. i dr. Aktivatsiya vrozhdennogo immuniteta pri shizofrenii. Zhurn nevrol i psikhiat 2006; 106: 10: 61-65.
Shcherbakova I.V., Klyushnik T.P. Immunnaya sistema i shizofreniya: kliniko-biologicheskie vzaimosvyazi (obzor sostoyaniya problemy). Psikhiatriya 2006; 6: 48-61.
Butcher S.K., Chahal H., Nayak L. et al. Senescence in innate responses: reduced neutrophil phagocytic capacity and CD16 expression in elderly humans. J Leukoc Biol 2001; 70: 881.
Kolyaskina G.I., Sekirina T.P., Androsova L.V. et al. Immunological studies in schizophrenia. Ann of Psychiatry 1996; 6: 105-122.
Mayilan K.R., Weinberger D.R., Sim R.B. The complement system in schizophrenia. Drug News Perspect 2008; 21: 4: 200-210.
Muller N., Reidel M., Gruber R. et al. The immune system and schizophrenia: an integrative view. Ann of NY Acad Sciences 2000; 917: 456-467.
Pae Cu., Yoon C.H., Kim T.S. et al. Antipsychotic treatment may alter T-helper (TH) 2 arm cytokines. Int Immunopharmacol 2006; 6: 4: 666-671.
Sasaki T., Nanko S., Fukuda R. et al. Changes of immunological functions after acute exacerbation in schizophrenia. Biol Psychiatry 1994; 35: 3: 173-178.
Schwarz M.J., Chiang S., Müller N. et al. T-helper-1 and T-helper-2 responses on psychiatric disorders. Brain Behav Immun 2001; 15: 4: 340-370.
Thomas A., Davis S., Morris Ch. et al. Increase in interleukin-1β in late-life depression. Am J Psychiat 2005; 162: 1: 175-177.
Vollmer-Conna U., Fazou C., Cameron B. et al. Production of proinflammatory cytokines correlates with the symptoms of acute sickness behaviour in humans. Psychol Med 2004; 34: 7: 1289-1297.