Mitochondrial dysfunction in neurodegenerative diseases

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Sudakov N.P.

Nauchnyĭ tsentr rekonstruktivnoĭ i vosstanovitel'noĭ khirurgii

Byval'tsev V.A.

otdel neĭrokhirurgii i ortopedii Nauchnogo tsentra rekonstruktivnoĭ i vosstanovitel'noĭ khirurgii Sibirskogo otdeleniia RAMN;
NUZ Dorozhnaia klinicheskaia bol'nitsa OAO "RZhD", Irkutsk

Nikiforov S.B.

Laboratoriia neĭrokhirurgii Nauchnogo tsentra rekonstruktivnoĭ i vosstanovitel'noĭ khirurgii (NTsRVKh) SO RAMN

Sorokovikov V.A.

Nauchnyĭ tsentr rekonstruktivnoĭ i vosstanovitel'noĭ khirurgii Sibirskogo otdeleniia RAMN, Irkutsk;
GBOU DPO "Irkutskaia gosudarstvennaia meditsinskaia akademiia poslediplomnogo obrazovaniia"

Klimenkov I.V.

Limnologicheskiĭ institut Sibirskogo otdeleniia Rossiĭskoĭ akademii nauk, Irkutsk

Konstantinov Iu.M.

Sibirskiĭ institut fiziologii i biokhimii rasteniĭ

Mitochondrial dysfunction in neurodegenerative diseases

Authors:

Sudakov N.P., Byval'tsev V.A., Nikiforov S.B., Sorokovikov V.A., Klimenkov I.V., Konstantinov Iu.M.

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Journal: S.S. Korsakov Journal of Neurology and Psychiatry. 2010;110(9): 87‑91

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To cite this article:

Sudakov NP, Byval'tsev VA, Nikiforov SB, Sorokovikov VA, Klimenkov IV, Konstantinov IuM. Mitochondrial dysfunction in neurodegenerative diseases. S.S. Korsakov Journal of Neurology and Psychiatry. 2010;110(9):87‑91. (In Russ.)

Подписка 2026 Журнал неврологии и психиатрии им. С.С. Корсакова (S.S. Korsakov Journal of Neurology and Psychiatry)

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Abstract:

Keywords:

mitochondria

neurodegenerative processes

programmed cell death

stress of endoplasmic reticulum

Authors:

Sudakov N.P.

Nauchnyĭ tsentr rekonstruktivnoĭ i vosstanovitel'noĭ khirurgii

Byval'tsev V.A.

otdel neĭrokhirurgii i ortopedii Nauchnogo tsentra rekonstruktivnoĭ i vosstanovitel'noĭ khirurgii Sibirskogo otdeleniia RAMN;
NUZ Dorozhnaia klinicheskaia bol'nitsa OAO "RZhD", Irkutsk

Nikiforov S.B.

Laboratoriia neĭrokhirurgii Nauchnogo tsentra rekonstruktivnoĭ i vosstanovitel'noĭ khirurgii (NTsRVKh) SO RAMN

Sorokovikov V.A.

Nauchnyĭ tsentr rekonstruktivnoĭ i vosstanovitel'noĭ khirurgii Sibirskogo otdeleniia RAMN, Irkutsk;
GBOU DPO "Irkutskaia gosudarstvennaia meditsinskaia akademiia poslediplomnogo obrazovaniia"

Klimenkov I.V.

Limnologicheskiĭ institut Sibirskogo otdeleniia Rossiĭskoĭ akademii nauk, Irkutsk

Konstantinov Iu.M.

Sibirskiĭ institut fiziologii i biokhimii rasteniĭ

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References:

Atamna H., Boyle K. Amyloid-β peptide binds with heme to form a peroxidase: Relationship to the cytopathologies of Alzheimer's disease. Proc Natl Acad Sci USA 2006; 103: 3381-338.
Auchère F., Santos R., Planamente S. et al. Glutathione-dependent redox status of frataxin-deficient cells in a yeast model of Friedreich's ataxia. Hum Mol Genet 2008; 17: 2790-2802.
Bae B.I., Xu H., Igarashi S. et al. p53 mediates cellular dysfunction and behavioral abnormalities in Huntington's disease. Neuron 2005; 47: 29-41.
Barsoum M.J., Yuan H., Gerencser A.A. et al. Nitric oxide-induced mitochondrial fission is regulated by dynamin-related GTPases in neurons. EMBO J 2006; 25: 3900-3911.
Bilsland L.G., Nirmalananthan N., Yip J. et al. Expression of mutant SOD1 in astrocytes induces functional deficits in motoneuron mitochondria. J Neurochem 2008; 107: 1271-1283.
Cardoso S.M., Oliveira C.R. The role of calcineurin in amyloid-β-peptides-mediated cell death. Brain Res 2005; 1050: 1-7.
Chee F.C., Mudher A., Cuttle M.F. et al. Over-expression of τ-results in defective synaptic transmission in Drosophila neuromuscular junctions. Neurobiol Dis 2005; 20: 918-928.
Chen X., Yan S.D. Mitochondrial Aβ: a potential cause of metabolic dysfunction in Alzheimer's disease. IUBMB Life 2006; 58: 686-694.
Chou A.H., Yeh T.H., Kuo Y.L. et al. Polyglutamine-expanded ataxin-3 activates mitochondrial apoptotic pathway by upregulating Bax and downregulating Bcl-xL. Neurobiol Dis 2006; 21: 333-345.
De Vos K.J., Chapman A.L., Tennant M.E. et al. Familial amyotrophic lateral sclerosis-linked SOD1 mutants perturb fast axonal transport to reduce axonal mitochondria content. Hum Mol Genet 2007; 16: 2720-2728.
Deniaud A., Sharaf el dein O., Maillier E. et al. Endoplasmic reticulum stress induces calcium-dependent permeability transition, mitochondrial outer membrane permeabilization and apoptosis. Oncogene 2008; 27: 285-299.
Devi L., Prabhu B.M., Galati D.F. et al. Accumulation of amyloid precursor protein in the mitochondrial import channels of human Alzheimer's disease brain is associated with mitochondrial dysfunction. J Neurosci 2006; 26: 9057-9068.
Devi L., Raghavendran V., Prabhu B.M. et al. Mitochondrial import and accumulation of α-synuclein impair complex I in human dopaminergic neuronal cultures and Parkinson disease brain. J Biol Chem 2008; 283: 9089-9100.
Friedlander R.M. Apoptosis and caspases in neurodegenerative diseases. N Engl J Med 2003; 348: 1365-1375.
Guégan C., Przedborski S. Programmed cell death in amyotrophic lateral sclerosis. J Clin Invest 2003; 111: 153-161.
Han C., Nam M.K., Park H.J. et al. Tunicamycin-induced ER stress upregulates the expression of mitochondrial HtrA2 and promotes apoptosis through the cytosolic release of HtrA2. J Microbiol Biotechnol 2008; 18: 1197-1202.
Hansen J., Corydon T.J., Palmfeldt J. et al. Decreased expression of the mitochondrial matrix proteases Lon and ClpP in cells from a patient with hereditary spastic paraplegia (SPG13). Neuroscience 2008; 153: 474-482.
Höglinger G.U., Lannuzel A., Khondiker M.E. et al. The mitochondrial complex I inhibitor rotenone triggers a cerebral tauopathy. J Neurochem 2005; 95: 930-939.
Ilieva E.V., Ayala V., Jové M. et al. Oxidative and endoplasmic reticulum stress interplay in sporadic amyotrophic lateral sclerosis. Brain 2007; 130: 3111-3123.
Inoue S. In situ Abeta pores in AD brain are cylindrical assembly of Abeta protofilaments. Amyloid 2008; 15: 223-233.
Jin J.K., Kim N.H., Lee Y.J. et al. Phospholipase D1 is up-regulated in the mitochondrial fraction from the brains of Alzheimer's disease patients. Neurosci Lett 2006; 407: 263-267.
Junn E., Jang W.H., Zhao X. et al. Mitochondrial localization of DJ-1 leads to enhanced neuroprotection. J Neurosci Res 2009; 87: 123-129.
Kilbride S.M., Telford J.E., Tipton K.F., Davey G.P. Partial inhibition of complex I activity increases Ca-independent glutamate release rates from depolarized synaptosomes. J Neurochem 2008; 106: 826-834.
Lee C.S., Han E.S., Han Y.S., Bang H. Differential effect of calmodulin antagonists on MG132-induced mitochondrial dysfunction and cell death in PC12 cells. Brain Res Bull 2005; 67: 225-234.
Lee H.-J. Choi C., Lee S.-J. Membrane-bound α-synuclein has a high aggregation propensity and the ability to seed the aggregation of the cytosolic form. J Biol Chem 2002; 277: 671-678.
Leegwater-Kim J., Cha J.-H. J. The paradigm of Huntington's disease: therapeutic opportunites in neurodegeneration. NeuroRx 2004; 1: 128-138.
Matus S., Lisbona F., Torres M. et al. The stress rheostat: an interplay between the unfolded protein response (UPR) and autophagy in neurodegeneration. Curr Mol Med 2008; 8: 157-172.
Moreira P.I., Honda K., Liu Q. et al. Oxidative stress: the old enemy in Alzheimer's disease pathophysiology. Curr Alzheimer Res 2005; 2: 403-408.
Narendra D., Tanaka A., Suen D.F., Youle R.J. Parkin is recruited selectively to impaired mitochondria and promotes their autophagy. J Cell Biol 2008; 183: 795-803.
Parihar M.S., Parihar A., Fujita M. et al. Mitochondrial association of α-synuclein causes oxidative stress. Cell Mol Life Sci 2008; 65: 1272-1284.
Park J., Lee G., Chung J. The PINK1-Parkin pathway is involved in the regulation of mitochondrial remodeling process. Biochem Biophys Res Commun 2009; 378: 518-523.
Perlmutter D.H. Liver in α1-antitrypsyn deficiency: an aggregated protein induces mitochondrial injury. J Clin Invest 2002; 110: 1579-1583.
Petrasch-Parwez E., Nguyen H.P., Löbbecke-Schumacher M. et al. Cellular and subcellular localization of Huntingtin aggregates in the brain of a rat transgenic for Huntington disease. J Comp Neurol 2007; 501: 716-730.
Plun-Favreau H., Gandhi S., Wood-Kaczmar A. et al. What have PINK1 and HtrA2 genes told us about the role of mitochondria in Parkinson's disease? Ann N Y Acad Sci 2008; 1147: 30-36.
Poole A.C., Thomas R.E., Andrews L.A. et al. The PINK1/Parkin pathway regulates mitochondrial morphology. Proc Natl Acad Sci USA 2008; 105: 1638-1643.
Reddy P.H., Beal M.F. Amyloid β, mitochondrial dysfunction and synaptic damage: implications for cognitive decline in aging and Alzheimer's disease. Trends Mol Med 2008; 14: 45-53.
Schmidt C., Lepsverdize E., Chi S.L. et al. Amyloid precursor protein and amyloid β-peptide bind to ATP synthase and regulate its activity at the surface of neural cells. Mol Psychiat 2008; 13: 953-969.
Sierra A., Gottfried-Blackmore A.C., McEwen B.S., Bulloch K. Microglia derived from aging mice exhibit an altered inflammatory profile. Glia 2007; 55: 412-424.
Smith W.W., Jiang H., Pei Z. et al. Endoplasmic reticulum stress and mitochondrial cell death pathways mediate A53T mutant α-synuclein-induced toxicity. Hum Mol Genet 2005; 14: 3801-3811.
Stoica B.A., Movsesyan V.A., Knoblach S.M., Faden A.I. Ceramide induces neuronal apoptosis through mitogen-activated protein kinases and causes release of multiple mitochondrial proteins. Mol Cell Neurosci 2005; 29: 355-371.
Sullivan P.G., Dragicevic N.B., Deng J.H. et al. Proteasome inhibition alters neural mitochondrial homeostasis and mitochondria turnover. J Biol Chem 2004; 279: 20699-20707.
Thies E., Mandelkow E.M. Missorting of tau in neurons causes degeneration of synapses that can be rescued by the kinase MARK2/Par-1. J Neurosci 2007; 27: 2896-2907.
Trushina E., Dyer R.B., Badger J.D. 2nd et al. Mutant huntingtin impairs axonal trafficking in mammalian neurons in vivo and in vitro. Mol Cell Biol 2004; 24: 8195-8209.
Wang X., Su B., Siedlak S.L., Moreira P.I. et al. Amyloid-β overproduction causes abnormal mitochondrial dynamics via differential modulation of mitochondrial fission/fusion proteins. Proc Natl Acad Sci USA 2008; 105: 19318-19323.
Xu C., Bailly-Maitre B., Reed J.C. Endoplasmic reticulum stress: cell life and death decisions. J Clin Invest 2005; 115: 2656-2664.
Yin K.J., Lee J.M., Chen H. et al. Aβ25-35 alters Akt activity, resulting in Bad translocation and mitochondrial dysfunction in cerebrovascular endothelial cells. J. Cereb. Blood Flow Metab 2005; 25: 1445-1455.
Yoon S., Choi J., Yoon J. et al. Okadaic acid induces JNK activation, bim overexpression and mitochondrial dysfunction in cultured rat cortical neurons. Neurosci Lett 2006; 394: 190-195.
Zatz M., Starling A. Calpains and disease. N Engl J Med 2005; 352: 2413-2423.
Zeevalk G.D., Bernard L.P. Energy status, ubiquitin proteasomal function, and oxidative stress during chronic and acute complex I inhibition with rotenone in mesencephalic cultures. Antioxid Redox Signal 2005; 7: 662-672.

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