Autoimmune encephalitis in psychiatric institution (clinical case)

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Khannanova A.N.

Gilyarovsky Psychiatric Hospital, the branch of the Psychiatric Clinical Hospital No. 4 of the Moscow Health Department

Nabiev Sh.R.

Buyanov Moscow City Clinical Hospital

Fominykh V.V.

Buyanov City Clinical Hospital;
Institute of Higher Nervous Activity and Neurophysiology

Golyakhovskaya A.Ya.

Mental Health Clinic No. 4 named after P.B. Gannushkin

Brylev L.V.

Buyanov City Clinical Hospital;
Institute of Higher Nervous Activity and Neurophysiology;
Solovyov Scientific and Practical Psychoneurological Center

SPIN RSCI: 9749-8920
Scopus AuthorID: 23110301900
ORCID: 0000-0003-2314-6523

Autoimmune encephalitis in psychiatric institution (clinical case)

Authors:

Khannanova A.N., Nabiev Sh.R., Fominykh V.V., Golyakhovskaya A.Ya., Brylev L.V.

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Journal: S.S. Korsakov Journal of Neurology and Psychiatry. 2022;122(1‑2): 49‑54

DOI: 10.17116/jnevro202212201249

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To cite this article:

Khannanova AN, Nabiev ShR, Fominykh VV, Golyakhovskaya AYa, Brylev LV. Autoimmune encephalitis in psychiatric institution (clinical case). S.S. Korsakov Journal of Neurology and Psychiatry. 2022;122(1‑2):49‑54. (In Russ.)
https://doi.org/10.17116/jnevro202212201249

Подписка 2026 Журнал неврологии и психиатрии им. С.С. Корсакова. Спецвыпуски (S.S. Korsakov Journal of Neurology and Psychiatry (special issues))

Использование инфографики авторами научных работ

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Abstract:

Currently there is a new concept of «molecular neuropsychiatry» which aim is identification of biomarkers and biological substrates for mental disorders. Autoimmune encephalitis can start with psychiatric symptoms in 60% of cases. In this article we described a clinical case of a patient, 31 years old, with GABAb-associated AE started with acute polymorphic psychosis. AE was diagnosed and treated in time with a good clinical effect. According to the frequency of psychiatric symptoms in AE patients it should be reasonable to include antineuronal test in CSF and serum in patients with first acute psychosis if «red flags» or atypical course of the disease.

Keywords:

autoimmune encephalitis

autoimmune psychosis

GABAb

molecular psychiatry

Authors:

Khannanova A.N.

Gilyarovsky Psychiatric Hospital, the branch of the Psychiatric Clinical Hospital No. 4 of the Moscow Health Department

Nabiev Sh.R.

Buyanov Moscow City Clinical Hospital

Fominykh V.V.

Buyanov City Clinical Hospital;
Institute of Higher Nervous Activity and Neurophysiology

Golyakhovskaya A.Ya.

Mental Health Clinic No. 4 named after P.B. Gannushkin

Brylev L.V.

Buyanov City Clinical Hospital;
Institute of Higher Nervous Activity and Neurophysiology;
Solovyov Scientific and Practical Psychoneurological Center

SPIN RSCI: 9749-8920
Scopus AuthorID: 23110301900
ORCID: 0000-0003-2314-6523

Received:

17.11.2021

Accepted:

28.12.2021

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References:

Herken J, Prüss H. Red Flags: Clinical Signs for Identifying Autoimmune Encephalitis in Psychiatric Patients. Front Psychiatry. 2017;8:25. Published online 2017 Feb 16. https://doi.org/10.3389/fpsyt.2017.00025
Al-Diwani A, Pollak TA, Langford AE, Lennox BR. Synaptic and Neuronal Autoantibody-Associated Psychiatric Syndromes: Controversies and Hypotheses. Front Psychiatry. 2017;8:13. Published online 2017 Feb 6. https://doi.org/10.3389/fpsyt.2017.00013
Malin DJ, Gladyshev VN. Neuroleptic malignant syndrome or autoimmune anti-NMDA receptor encephalitis? Analysis of a fatal clinical case. Socialnaya i Clinicheskaya Psihsatria. 2017;1. (In Russ.). Link active on 10/30/2021. https://cyberleninka.ru/article/n/zlokachestvennyy-neyrolepticheskiy-sindrom-ili-autoimmunnyy-anti-nmda-retseptornyy-entsefalit-razbor-klinicheskogo-sluchaya-s/viewer
Vitaliani R, Mason W, Ances B, Zwerdling T, Jiang Z, Dalmau J. Paraneoplastic encephalitis, psychiatric symptoms, and hypoventilation in ovarian teratoma. Ann Neurol. 2005;58:594-604. https://doi.org/10.1002/ana.20614
Lancaster E, Lai M, Peng X, Hughes E, Constantinescu R, Raizer J, Friedman D, Skeen MB, Grisold W, Kimura A, Ohta K, Iizuka T, Guzman M, Graus F, Moss SJ, Balice-Gordon R, Dalmau J. Antibodies to the GABAB receptor in limbic encephalitis with seizures: case series and characterisation of the antigen. Lancet Neurol. 2010;9:1:67-76. https://doi.org/10.1016/s1474-4422(09)70324-2
Petit-Pedrol M, Armangue T, Peng X, Bataller L, Cellucci T, Davis R, McCracken L, Martinez-Hernandez E, Mason WP, Kruer MC, Ritacco DG, Grisold W, Meaney BF, Alcalá C, Sillevis-Smitt P, Titulaer MJ, Balice-Gordon R, Graus F, Dalmau J. Encephalitis with refractory seizures, status epilepticus, and antibodies to the GABAA receptor: a case series, characterisation of the antigen, and analysis of the effects of antibodies. Lancet Neurol. 2014;13:3:276-286. https://doi.org/10.1016/s1474-4422(13)70299-0
Pettingill P, Kramer HB, Coebergh JA, Pettingill R, Maxwell S, Nibber A. et al. Antibodies to GABAA receptor α1 and γ2 subunits: clinical and serologic characterization. Neurology. 2015;84:1233-1241. https://doi.org/10.1212/wnl.0000000000001326
Neznanov NG, Shmukler AB, Kostyuk GP, Sofronov AG. The first psychotic episode: epidemiological aspects of care provision. Socialnaya i Clinicheskaya Psihiatria. 2018;28:3:5-11. (In Russ.) Link active on 10/30/2021. https://cyberleninka.ru/article/n/pervyy-psihoticheskiy-epizod-epidemiologicheskie-aspekty-organizatsii-pomoschi/viewer
Pollak TA, Lennox BR, Müller S, Benros ME, Prüss H, Tebartz van Elst L, Klein H, Steiner J, Frodl T, Bogerts B, Tian L, Groc L, Hasan A, Baune BT, Endres D, Haroon E, Yolken R, Benedetti F, Halaris A, Meyer JH, Stassen H, Leboyer M, Fuchs D, Otto M, Brown DA, Vincent A, Najjar S, Bechter K. Autoimmune psychosis: an international consensus on an approach to the diagnosis and management of psychosis of suspected autoimmune origin. Lancet Psychiatry. 2020;7(1):93-108. https://doi.org/10.1016/s2215-0366(19)30290-1
Fominykh V, Brylev L, Gaskin V, Luzin R, Yakovlev A, Komoltsev I, Belousova I, Rosliakova A, Guekht A, Gulyaeva N. Neuronal damage and neuroinflammation markers in patients with autoimmune encephalitis and multiple sclerosis. Metab Brain Dis. 2019;34(5):1473-1485. https://doi.org/10.1007/s11011-019-00452-x
Gareeva KS, Valinurov RG, Khritinin DF. Anti-NMDA receptor encephalitis in the practice of a psychiatrist on the example of a clinical case. Vestnik Nevrologii, Psikhiatrii i Neirokhirurgii. 2021;8. (In Russ.). Link active on 10/30/2021. https://panor.ru/articles/autoimmunnyy-entsefalit-assotsiirovannyy-s-antitelami-k-nmda-retseptoram-neyronov-v-praktike-vracha-psikhiatra-klinicheskiy-sluchay/70265.html
Coyle JT. Glutamate and schizophrenia: beyond the dopamine hypothesis. Cell Mol Neurobiol. 2006;26(4-6):365-384. https://doi.org/10.1007/s10571-006-9062-8
Yee BK, Keist R, von Boehmer L, Studer R, Benke D, Hagenbuch N, et al. A schizophrenia-related sensorimotor deficit links alpha 3-containing GABAA receptors to a dopamine hyperfunction. Proc Natl Acad Sci USA. 2005;102(47):17154-17159. https://doi.org/10.1073/pnas.0508752102
Ishikawa M, Mizukami K, Iwakiri M, Asada T. Immunohistochemical and immunoblot analysis of gamma-aminobutyric acid B receptor in the prefrontal cortex of subjects with schizophrenia and bipolar disorder. Neurosci Lett. 2005;383(3):272-277. https://doi.org/10.1016/j.neulet.2005.04.025
Fatemi SH, Folsom TD, Thuras PD. Deficits in GABAB receptor system in schizophrenia and mood disorders: A postmortem study. Schizophr Res. 2011;128(1-3):37-43. https://doi.org/10.1016/j.schres.2010.12.025
Boronat A, Sabater L, Saiz A, Dalmau J, Graus F. GABA(B) receptor antibodies in limbic encephalitis and anti-GAD-associated neurologic disorders. Neurology. 2011;76(9):795-800. https://doi.org/10.1212/wnl.0b013e31820e7b8d
Haussleiter IS, Wandinger K, Juckel G. A case of GABAR antibodies in schizophrenia. BMC Psychiatry. 2017;17:9. Published online 2017 Jan 10. https://doi.org/10.1186/s12888-016-1157-2
Al-Diwani A, Handel A, Townsend L, Pollak T, Leite MI, Harrison PJ, Lennox BR, Okai D, Manohar SG, Irani SR. The psychopathology of NMDAR-antibody encephalitis in adults: a systematic review and phenotypic analysis of individual patient data. Lancet Psychiatry. 2019;6(3):235-246. https://doi.org/10.1016/S2215-0366(19)30001-X
Endres D, Leypoldt F, Bechter K, Hasan A, Steiner J, Domschke K, Wandinger K, Falkai P, Arolt V, Stich O, Rauer S, Prüss H, Tebartz L van E. Autoimmune encephalitis as a differential diagnosis of schizophreniform psychosis: clinical symptomatology, pathophysiology, diagnostic approach, and therapeutic considerations. Eur Arch Psychiatry Clin Neurosci. 2020;270(7):803-818. Published online 2020 Mar 12. https://doi.org/10.1007/s00406-020-01113-2

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