D-lactate as a novel somnogenic factor?

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OBJECTIVE

To evaluate an influence of intracerebral L-lactate concentration on sleep-wake cycle.

MATERIAL AND METHODS

Twenty adult male white rats preliminary implanted (under general anesthesia) with the electrodes for neocortical EEG and a single cannula to a lateral ventricle were used as subjects. A 5 µl bolus of either saline or a solution of sodium L- or D-lactate (0.1 mg, 0.2 M, Sigma-Aldrich) was injected through the cannula and followed by a 6-hr recording.

RESULTS AND CONCLUSION

Administration of L-lactate does not influence sleep-wake cycle of experimental animals. At the same time, its artificial optical analog D-lactate induces the significant (as compared to the control) decrease in wake (34.8% to 26.5%) and increase in slow wave sleep (57.4% to 69.2%). It has been suggested that D-lactate may be the antagonist of one or several L-lactate receptors.

Keywords:

sleep-wake

lactate

Authors:

Kovalzon V.M.

Severtsov Institute of Ecology and Evolution of the Russian Academy of Sciences;
Kharkhevich Institute of Information Transmission of the Russian Academy of Sciences

Panchin Yu.V.

Kharkhevich Institute of Information Transmission of the Russian Academy of Sciences;
Belozerskiy Institute of Physical-Chemical Biology of Lomonosov Moscow State University

Received:

02.03.2020

Accepted:

20.03.2020

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