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Kirasirova E.A.

Pirogov Russian National Research Medical University;
Sverzhevsky Research Clinical Institute for Otolaryngology

Shulga O.V.

Pirogov Russian National Research Medical University

Lafutkina N.V.

Sverzhevsky Research Clinical Institute for Otolaryngology

Mamedov R.F.

Sverzhevsky Research Clinical Institute for Otolaryngology

Piminidi O.K.

Sverzhevsky Research Institute of Clinical Otorhinolaryngology

Tyutina S.I.

Sverzhevsky Research Clinical Institute of Otorhinolaryngology

Yumatova D.A.

Pirogov Russian National Research Medical University

Trusov V.A.

Pirogov Russian National Research Medical University

Modern conservative therapy of scar stenosis of the larynx and trachea. Literature review

Authors:

Kirasirova E.A., Shulga O.V., Lafutkina N.V., Mamedov R.F., Piminidi O.K., Tyutina S.I., Yumatova D.A., Trusov V.A.

More about the authors

Journal: Russian Bulletin of Otorhinolaryngology. 2025;90(4): 91‑95

DOI: 10.17116/otorino20259004191

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Table of contents

MODERN CONSERVATIVE THERAPY OF SCAR STENOSIS OF THE LARYNX AND TRACHEA. LITERATURE REVIEW
MODERN CONSERVATIVE THERAPY OF SCAR STENOSIS OF THE LARYNX AND TRACHEA. LITERATURE REVIEW

To cite this article:

Kirasirova EA, Shulga OV, Lafutkina NV, et al. . Modern conservative therapy of scar stenosis of the larynx and trachea. Literature review. Russian Bulletin of Otorhinolaryngology. 2025;90(4):91‑95. (In Russ.)
https://doi.org/10.17116/otorino20259004191

Подписка 2026 Вестник оториноларингологии (Russian Bulletin of Otorhinolaryngology)
 
МСФ на ЯМ
Использование инфографики авторами научных работ
Recommended articles:
A new approach to surgical treatment of exte­nded chro­nic cica­tricial stenosis of the larynx and trachea. Russian Bulletin of Otorhinolaryngology. 2025;(2):9-13
Abstract:

The article presents a review of the literature, in which the possibilities of conservative therapy in the treatment of chronic scar stenosis of the larynx and cervical trachea are considered. Due to the high risk of restenosis of the larynx and cervical trachea lumen in the postoperative period, the problem under consideration remains topical. The authors have systematised modern literature data on the groups of used drugs, mechanisms of action and routes of delivery, advantages and disadvantages, and reviewed the experience of their use in otorhinolaryngology.

Keywords:

scar stenosis of the larynx and trachea
anti-scar therapy
triamcinolone
Longidaza

Authors:

Kirasirova E.A.

Pirogov Russian National Research Medical University;
Sverzhevsky Research Clinical Institute for Otolaryngology

Shulga O.V.

Pirogov Russian National Research Medical University

Lafutkina N.V.

Sverzhevsky Research Clinical Institute for Otolaryngology

Mamedov R.F.

Sverzhevsky Research Clinical Institute for Otolaryngology

Piminidi O.K.

Sverzhevsky Research Institute of Clinical Otorhinolaryngology

Tyutina S.I.

Sverzhevsky Research Clinical Institute of Otorhinolaryngology

Yumatova D.A.

Pirogov Russian National Research Medical University

Trusov V.A.

Pirogov Russian National Research Medical University

Received:

23.11.2024

Accepted:

17.02.2025

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References:

  1. Sanginov AB, Mosin IV, Mosina NV. Etiology and pathogenesis of cicatricial stenosis of the trachea. Vestnik Avitsenny. 2010;1:33-39. (In Russ.).
  2. Lafutkina NV. Algoritm vedeniya bol’nykh, perenesshikh trakheostomiyu v otdelenii intensivnoj terapii: Diss. ... kand. med. nauk. M. 2008. (In Russ.).
  3. Parshin VD, Rusakov MA, Parshin AV, Pryanikov PD, Parshin VV, Ursov MA, Mariiko AV. O trakheostomii pri rubtsovom stenoze trakhei. Head and Neck. Golova i sheya. Rossijskij zhurnal. 2024;12(2):86-96. (In Russ.). https://doi.org/10.25792/HN.2024.12.2.86-96
  4. Sarper A, Ayten A, Eser I, Ozbudak O, Demircan A. Tracheal stenosis aftertracheostomy or intubation: review with special regard to cause and management. Texas Heart Institute Journal. 2005;32(2):154-158. 
  5. Rosow DE, Barbarite E. Review of adult laryngotracheal stenosis: pathogenesis, management, and outcomes. Current Opinion in Otolaryngology and Head and Neck Surgery. 2016;24(6):489-493.  https://doi.org/10.1097/MOO.0000000000000305
  6. Zenger VG, Nasedkin AN, Parshin VD. Khirurgiya povrezhdenij gortani i trakhei. M.: Medkniga; 2007. (In Russ).
  7. Kirasirova EA, Lafutkina NV, Mamedov RF, Piminidi OK, Gogoreva NR, Rezakov RA, Kuzina EA. Reconstructive surgery for stenosis of the larynx and trachea of various etiologies. Vestnik KazNMU. 2014;2-3:65-66. (In Russ).
  8. Krukov AI, Gurov AV, Kirasirova EA, Kulabuhov EV. Modern methods of the prevention and treatment of complications in reconstructive surgery in patients with stenosis of the larynx and trachea. Russian Bulletin of Otorhinolaryngology. 2019;84(6):48-53. (In Russ.). https://doi.org/10.17116/otorino20198406148
  9. Kirasirova EA, Oltarzhevskaya ND, Khlystova TS, Usova MI, Lafutkina NV, Mamedov RF, Rezakov RA, Kulabukhov EV, Tyutina SI, Egorova EA. Modern aspects of laryngeal and tracheal lumen prosthetics after reconstructive surgery. RMZh. 2022;2:36-40. (In Russ.).
  10. Parker NP, Bandyopadhyay D, Misono S, Goding GS Jr. Endoscopic cold incision, balloon dilation, mitomycin C application, and steroid injection for adult laryngotracheal stenosis. Laryngoscope. 2013;123(1):220-225.  https://doi.org/10.1002/lary.23638
  11. Kirasirova EA, Frolkina EA, Rezakov RA, Mamedov RF, Lafutkina NV, Rybal’chenko IE, Tyutina SI, Trusov VA. Ispol’zovanie termicheskoj gelij-kislorodnoj smesi dlya korrektsii dykhatel’noj nedostatochnosti v kompleksnom lechenii patsientov s rubtsovym stenozom gortani i trakhei. Head and Neck. Golova i sheya. Rossijskij zhurnal. 2022;10(4):24-29.  https://doi.org/10.25792/HN.2022.10.4.24-29
  12. Gosman RE, Sicard RM, Cohen SM, Frank-Ito DO. Comparison of Inhaled Drug Delivery in Patients With One- and Two-level Laryngotracheal Stenosis. Laryngoscope. 2023;133(2):366-374.  https://doi.org/10.1002/lary.30212
  13. Kirasirova EA, Gurov AA, Kulabuhov EV, Lafutkina NV, Usova MI. Therapeutic management of patients with chronic stenosis of the larynx and trachea. Meditsinskij sovet. 2020;(16):36-42. (In Russ.). https://doi.org/10.21518/2079-701X-2020-16-36-42
  14. Kurgansky IS, Makhutov VN, Lepekhova SA. The methods for the treatment and prevention of cicatricalstenoses of tracheal. Russian Bulletin of Otorhinolaryngology. 2016;81(1):66-71. (In Russ.). https://doi.org/10.17116/otorino201681166-71
  15. Dorovskikh VA, Batalova TA, Sergievich AA, Urazova GE. Glyukokortikoidy: ot teorii k praktike. Uchebnoe posobie. Blagoveshchensk; 2006. (In Russ.).
  16. Shadmehr MB, Abbasidezfouli A, Farzanegan R, Pejhan S, Daneshvar Kakhaki A, Sheikhy K, Saghebi SR, Sadeghbeigee F, Gharedaghi A, Jahanshahi N, Zangi M. The Role of Systemic Steroids in Postintubation Tracheal Stenosis: A Randomized Clinical Trial. Annals of Thoracic Surgery. 2017;103(1):246-253.  https://doi.org/10.1016/j.athoracsur.2016.05.063
  17. Neevel AJ, Schuman AD, Morrison RJ, Hogikyan ND, Kupfer RA. Serial intralesional steroid injection for subglottic stenosis: systemic side effects and impact on surgery‐free interval. OTO Open. 2021;5:2473974×211054842. https://doi.org/10.1177/2473974X211054842
  18. Clinical guidelines «Rational use of nonsteroidal anti-inflammatory drugs (NSAIDs) in clinical practice». Part I. S.S. Korsakov Journal of Neurology and Psychiatry. 2015;115(4):70-82. (In Russ.). https://doi.org/10.17116/jnevro20151154170-82
  19. Dovgan’ EV. Clinical pharmacology of nonsteroidal anti-inflammatory drugs: a course towards safety. RMZh. 2017;25(13):979-985. (In Russ.).
  20. Duman E, Ceylan KC, Akpınar D, Yücel N, Ünsal Ş, Duman S, Kaya ŞÖ. The effects of steroidal and non-steroidal anti-inflammatory drugs on tracheal wound healing in an experimental rat model. Interactive Cardiovascular and Thoracic Surgery. 2020;30(4):646-651.  https://doi.org/10.1093/icvts/ivz309
  21. Mazhar K, Gunawardana M, Webster P, Hochstim C, Koempel J, Kokot N, Sinha U, Rice D, Baum M. Bacterial biofilms and increased bacterial counts are associated with airway stenosis. Otolaryngology — Head and Neck Surgery. 2014;150(5):834-840.  https://doi.org/10.1177/0194599814522765
  22. Rezakov RA. Patogeneticheskoe obosnovanie kompleksnogo podkhoda k lecheniyu bol’nykh stenozom gortani i trakhei: Diss. ... kand. med. nauk. M. 2015. (In Russ.).
  23. Giamarellos-Bourboulis EJ. Macrolides beyond the conventional antimicrobials: a class of potent immunomodulators. International Journal of Antimicrobial Agents. 2008;31(1):12-20.  https://doi.org/10.1016/j.ijantimicag.2007.08.001
  24. Choi JS, Kim JM, Kim JW, Kim YM, Park IS, Yang SG. Prevention of tracheal inflammation and fibrosis using nitinol stent coated with doxycycline. Laryngoscope. 2018;128(7):1558-1563. https://doi.org/10.1002/lary.27028
  25. Lamparter S, Slight SH, Weber KT. Doxycycline and tissue repair in rats. Journal of Laboratory and Clinical Medicine. 2002;139(5): 295-302.  https://doi.org/10.1067/mlc.2002.122624
  26. Vladimirova ES, Nikulina VP, Godkov MA, Kasholkina EA. Immunological Aspects of the Pathogenesis of Cicatricial Tracheal Stenosis. Zhurnal im. N.V. Sklifosovskogo. Neotlozhnaya meditsinskaya pomoshch’. 2023;12(3):428-434. (In Russ.). https://doi.org/10.23934/2223-9022-2023-12-3-428-434
  27. Shi W, Fang Y, Jiang Y, et al. Plumbagin attenuates traumatic tracheal stenosis in rats and inhibits lung fibroblast proliferation and differentiation via TGF-β1/Smad and Akt/mTOR pathways. Bioengineered. 2021;12(1):4475-4488. https://doi.org/10.1080/21655979.2021.1954580
  28. Simpson CB, White S, McGuff HS. Anti-transforming growth factor beta as a treatment for laryngotracheal stenosis in a canine model. Laryngoscope. 2008;118(3):546-551.  https://doi.org/10.1097/MLG.0b013e31815daf6e
  29. Kirasirova EA. Reabilitatsiya bol’nykh s travmaticheskim povrezhdeniem gortani i trakhei razlichnoj etiologii: Diss. ... d-ra med. nauk. M. 2004. (In Russ.).
  30. Cataneo DC, Ximenes AMG, Cataneo AJM. Mitomycin C in the endoscopic treatment of tracheal stenosis: a prospective cohort study. Jornal Brasileiro de Pneumologia. 2018;44(6):486-490.  https://doi.org/10.1590/S1806-37562017000000423
  31. Faisal M, Harun H, Hassan TM, Ban AY, Chotirmall SH, Abdul Rahaman JA. Treatment of multiple-level tracheobronchial stenosis secondary to endobronchial tuberculosis using bronchoscopic balloon dilatation with topical mitomycin-C. BMC Pulmonary Medicine. 2016;16(1):53.  https://doi.org/10.1186/s12890-016-0209-1
  32. Kuznetsov MR, Boldin BV, Rodionov SV, Turkin PIu, Komov KV, Virganskiĭ AO, Tugdumov BV, Rumiantseva EI. Prevention of stenosis of vascular anastomoses after surgical treatment of patients with lower limb ischemia. Pirogov Russian Journal of Surgery. 2010;(11):56-61. (In Russ.).
  33. Golomedova AV. Longidaza v kompleksnoj terapii vpervye vyyavlennykh bol’nykh infil’trativnym tuberkulezom legkikh: Avtoref. diss. ... kand. med. nauk. M. 2010. (In Russ.).
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