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Ovchinnikov A.Yu.

Evdokimov Moscow State University of Medicine and Dentistry

Khon E.M.

Evdokimov Moscow State University of Medicine and Dentistry

Bakotina A.V.

A.I. Yevdokimov Moscow State University of Medicine and Dentistry

Miroshnichenko N.A.

Evdokimov Moscow State University of Medicine and Dentistry

Gronskaia S.A.

National Medical Research Center for Endocrinology

Belaya Zh.E.

National Medical Research Center for Endocrinology

FGF23 tumor induced osteomalacia with localization of neoplasm in the tympanic cavity

Authors:

Ovchinnikov A.Yu., Khon E.M., Bakotina A.V., Miroshnichenko N.A., Gronskaia S.A., Belaya Zh.E.

More about the authors

Journal: Russian Bulletin of Otorhinolaryngology. 2023;88(6): 91‑96

DOI: 10.17116/otorino20238806191

Views: 921

Downloaded: 5

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Table of contents

To cite this article:

Ovchinnikov AYu, Khon EM, Bakotina AV, Miroshnichenko NA, Gronskaia SA, Belaya ZhE. FGF23 tumor induced osteomalacia with localization of neoplasm in the tympanic cavity. Russian Bulletin of Otorhinolaryngology. 2023;88(6):91‑96. (In Russ.)
https://doi.org/10.17116/otorino20238806191

Подписка 2025 (Russian Bulletin of Otorhinolaryngology)
 
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Tumor induced osteomalacia is a rare paraneoplastic syndrome caused by mesenchymal tumors that secrete fibroblast growth factor 23 (FGF23). Patients complain of progressive bone pain, muscle weakness and brittle fractures. Delayed diagnosis of osteomalacia caused by a tumor is often found in clinical practice. When verifying the exact localization of the neoplasm, radical removal within healthy tissues is recommended. The article considers a clinical example of FGF23 tumor induced osteomalacia with localization of neoplasm in the tympanic cavity.

Keywords:

phosphorus
osteomalacia
tumor
hypophosphatemia
fibroblast growth factor 23
phosphaturic mesenchymal tumor

Authors:

Ovchinnikov A.Yu.

Evdokimov Moscow State University of Medicine and Dentistry

Khon E.M.

Evdokimov Moscow State University of Medicine and Dentistry

Bakotina A.V.

A.I. Yevdokimov Moscow State University of Medicine and Dentistry

Miroshnichenko N.A.

Evdokimov Moscow State University of Medicine and Dentistry

Gronskaia S.A.

National Medical Research Center for Endocrinology

Belaya Zh.E.

National Medical Research Center for Endocrinology

Received:

22.03.2022

Accepted:

13.06.2023

List of references:

  1. Kozhanov LG, Kozhanov AL, Romanova ES. Neoplasms of the upper respiratory tract and ear. Vestnik otorinolaringologii. 2021;86(1):96-102. (In Russ.). https://doi.org/10.17116/otorino20218601196
  2. Feng J, Jiang Y, Wang O, Li M, Xing X, Huo L, Li F, Yu W, Zhong DR, Jin J, Liu Y, Qi F, Lv W, Zhou L, Meng XW, Xia WB. The diagnostic dilemma of tumor induced osteomalacia: A retrospective analysis of 144 cases. Endocrine Journal. 2017;64(7):675-683.  https://doi.org/10.1507/endocrj.EJ16-0587
  3. Grebennikova TA, Umiarova DS, Slashchuk KY, Degtyarev MV, Rodionova SS, Rumiantsev P, Belaya Zh. Tumor-induced osteomalacia: A clinical case report. Osteoporosis and Bone Diseases. 2019;21(4):24-28.  https://doi.org/10.14341/osteo10264
  4. Gronskaia SA, Belaya ZE, Melnichenko GA. FGF23 tumor induced osteomalacia. Problemy endokrinologii. 2022;68(5):56-66. (In Russ.). https://doi.org/10.14341/probl13130
  5. Gronskaia SA, Belaya ZE, Rozhinskaya LY, Melnichenko GA, Dubovitskaya TA, Mamedova EO, Rodionova SS, Buklemishev YuV, Pigarova EA, Degtyarev MV, Babaeva DM, Vladimirova VP, Tarbaeva NV, Serzhenko SS, Grigoriev AYu, Dzeranova LK, Karpenko VYu, Karasev AL, Fedotov RN, Uliyanova IN, Toroptsova NV, Lesnyak OM, Mokrysheva NG, Dedov II. Clinical features, diagnostics and treatment of FGF23 secreting tumors: series of 40 clinical cases. Problemy endokrinologii. 2023;69(5):25-38. (In Russ.). https://doi.org/10.14341/probl13221
  6. Folpe AL. Phosphaturic mesenchymal tumors: A review and update. Seminars in Diagnostic Pathology. 2019;36:260-268.  https://doi.org/10.1053/j.semdp.2019.07.002.2
  7. Jan de Beur SM, Minisola S, Xia WB, Abrahamsen B, Body JJ, Brandi ML, Clifton-Bligh R, Collins M, Florenzano P, Houillier P, Imanishi Y, Imel EA, Khan AA, Zillikens MC, Fukumoto S. Global guidance for the recognition, diagnosis, and management of tumor-induced osteomalacia. Journal of Internal Medicine. 2023;293(3):309-328.  https://doi.org/10.1111/joim.13593
  8. Florenzano P, Hartley IR, Jimenez M, Roszko K, Gafni RI, Collins MT. Tumor-Induced Osteomalacia. Calcified Tissue International. 2021;108(1):128-142.  https://doi.org/10.1007/s00223-020-00691-6
  9. Ito N, Shimizu Y, Suzuki H, Saito T, Okamoto T, Hori M, Akahane M, Fukumoto S, Fujita T. Clinical utility of systemic venous sampling of FGF23 for identifying tumours responsible for tumour-induced osteomalacia. Journal of Internal Medicine. 2010;268(4):390-394.  https://doi.org/10.1111/j.1365-2796.2010.02262.x
  10. Andreopoulou P, Dumitrescu CE, Kelly MH, Brillante BA, Cutler Peck CM, Wodajo FM, Chang R, Collins MT. Selective venous catheterization for the localization of phosphaturic mesenchymal tumors. Journal of Bone and Mineral Research. 2011;26(6):1295-1302. https://doi.org/10.1002/jbmr.316
  11. Florenzano P, Hartley IR, Jimenez M, Roszko K, Gafni RI, Collins MT. Tumor-Induced Osteomalacia. Calcified Tissue International. 2021;108(1):128-142.  https://doi.org/10.1007/s00223-020-00691-6

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