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Svistushkin V.M.

Sechenov First Moscow State Medical University

Timashev P.S.

Institute for Regenerative Medicine of the I.M. Sechenov First Moscow State Medical University of the Ministry of Health of the Russian Federation (Sechenov University)

Shekhter A.B.

Institute for Regenerative Medicine of the I.M. Sechenov First Moscow State Medical University of the Ministry of Health of the Russian Federation (Sechenov University)

Zolotova A.V.

I.M. Sechenov First Moscow State Medical University of the Ministry of Health of the Russian Federation (Sechenov University)

Mokoyan Zh.T.

Sechenov First Moscow State Medical University

Svistushkin M.V.

I.M. Sechenov First Moscow State Medical University of the Ministry of Health of the Russian Federation (Sechenov University)

Experimental evidence for regenerative treatment of chronic tympanic membrane perforation

Authors:

Svistushkin V.M., Timashev P.S., Shekhter A.B., Zolotova A.V., Mokoyan Zh.T., Svistushkin M.V.

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Journal: Russian Bulletin of Otorhinolaryngology. 2020;85(6): 23‑26

DOI: 10.17116/otorino20208506123

Read: 1535 times

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Table of contents

EXPERIMENTAL EVIDENCE FOR REGENERATIVE TREATMENT OF CHRONIC TYMPANIC MEMBRANE PERFORATION
EXPERIMENTAL EVIDENCE FOR REGENERATIVE TREATMENT OF CHRONIC TYMPANIC MEMBRANE PERFORATION

To cite this article:

Svistushkin VM, Timashev PS, Shekhter AB, Zolotova AV, Mokoyan ZhT, Svistushkin MV. Experimental evidence for regenerative treatment of chronic tympanic membrane perforation. Russian Bulletin of Otorhinolaryngology. 2020;85(6):23‑26. (In Russ.)
https://doi.org/10.17116/otorino20208506123

Подписка 2026 Вестник оториноларингологии (Russian Bulletin of Otorhinolaryngology)
МСФ на ЯМ
Использование инфографики авторами научных работ
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Abstract:

OBJECTIVE

The aim of our study was an experimental evaluation of tissue engineering approach to chronic tympanic membrane perforation closure.

MATERIALS AND METHODS

Chronic tympanic membrane perforation models were created both sides in 12 chinchillas. Right sided perforations were divided into two equal groups (A and B) according to treatment; left sided perforations were used as a control group. Group A perforations were treated with collagen scaffold and fibroblast growth factor, group B perforations were treated with collagen scaffold only. During follow-up, we provided otovideoendoscopy for closure rates assessement every 2 weeks. In case of perforation closure, a morphological investigation of the regenerate was performed.

RESULTS

Group A perforations were totally closed 2 weeks after treatment in all animals. In group B, complete closure of perforation was achieved after the third treatment procedure in one case. There were no spontaneous perforation closure in the control group. According to morphological investigation, the restoration of trilaminar structure was observed only in tissue engineering group tympanic membranes.

Keywords:

chronic tympanic membrane perforation
tissue engineering
fibroblast growth factor
scaffold

Authors:

Svistushkin V.M.

Sechenov First Moscow State Medical University

Timashev P.S.

Institute for Regenerative Medicine of the I.M. Sechenov First Moscow State Medical University of the Ministry of Health of the Russian Federation (Sechenov University)

Shekhter A.B.

Institute for Regenerative Medicine of the I.M. Sechenov First Moscow State Medical University of the Ministry of Health of the Russian Federation (Sechenov University)

Zolotova A.V.

I.M. Sechenov First Moscow State Medical University of the Ministry of Health of the Russian Federation (Sechenov University)

Mokoyan Zh.T.

Sechenov First Moscow State Medical University

Svistushkin M.V.

I.M. Sechenov First Moscow State Medical University of the Ministry of Health of the Russian Federation (Sechenov University)

Received:

12.03.2020

Accepted:

25.04.2020

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References:

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