The site of the Media Sphera Publishers contains materials intended solely for healthcare professionals.
By closing this message, you confirm that you are a certified medical professional or a student of a medical educational institution.
Ostroumova O.D.
Kafedra fakul'tetskoĭ terapii i professional'nykh bolezneĭ Moskovskogo gosudarstvennogo mediko-stomatologicheskogo universiteta im. A.I. Evdokimova, Moskva
Shikh E.V.
Kafedra klinicheskoĭ farmakologii i propedevtiki vnutrennikh bolezneĭ GBOU VPO "Pervyĭ Moskovskiĭ gosudarstvennyĭ meditsinskiĭ universitet im. I.M. Sechenova"
Rebrova E.V.
Department of Clinical Pharmacology and Propaedeutics of Internal Diseases, Faculty of Medicine, I.M. Sechenov First Moscow State Medical University, Ministry of Health of Russia, Moscow, Russia, 119991
Ryazanova A.Yu.
Russian Clinical and Research Center of Gerontology, Moscow, Russia, 129226 ,Department of Clinical Pharmacology and Intensive Therapy with the course of clinical pharmacology of CVF, clinical allergology of the Volgograd State Medical University, Volgograd, Russia, 400131
Rhinitis medicamentosa
Journal: Russian Bulletin of Otorhinolaryngology. 2020;85(3): 75‑82
Views: 15918
Downloaded: 766
To cite this article:
Ostroumova OD, Shikh EV, Rebrova EV, Ryazanova AYu. Rhinitis medicamentosa. Russian Bulletin of Otorhinolaryngology.
2020;85(3):75‑82. (In Russ.)
https://doi.org/10.17116/otorino20208503175
One type of non-allergic non-infectious rhinitis is represented by a heterogeneous group of rhinitis medicamentosa, which can be divided into several pathogenetic types. The most common rebound nasal congestion associated with the use of topical decongestants. Excessive use of intranasal decongestants leads to a decrease in the number of alpha-adrenoreceptors on the surface of cell membranes and uncoupling their connection with the G-protein and the development of tachyphylaxis. To prevent the development of rebound nasal congestion caused by topical decongestants, it is important to limit the frequency of their use. In most cases, the duration of the use of vasoconstrictor drugs should be limited to 5-7 days, according to Patient information leaflets for the drugs. However, in patients who have had a history of episodes of rebound nasal congestion, which develops including the previously indicated periods, the duration of decongestant therapy should be limited to 3 days. Rhinitis associated with local inflammation is caused by the intake of acetylsalicylic acid (ASA) or other non-steroidal anti-inflammatory drugs. Currently, the so-called “aspirin triad” is well known — a combination of bronchial asthma, rhinosinusitis (often polyposis) and intolerance to ASA. Neurogenic rhinitis develops due to the use of drugs that violate vascular tone, for example, antihypertensive drugs or type 5 phosphodiesterase inhibitors. Drug-induced rhinitis has a significant impact on the patient’s quality of life: nasal congestion, rhinorrhea, secondary night apnea, insomnia as a result of nasal breathing disturbances, headaches, irritability, weakness after sleepless nights disturb patients to a large extent. Timely diagnosis and withdrawal of a provocative drug, the use of topical corticosteroids in case of severe rhinitis are the basis of the treatment of rhinitis medicamentosa. In severe cases, there is a need, including surgical treatment, such as, for example, submucosal laser destruction of the lower nasal concha.
Keywords:
Authors:
Ostroumova O.D.
Kafedra fakul'tetskoĭ terapii i professional'nykh bolezneĭ Moskovskogo gosudarstvennogo mediko-stomatologicheskogo universiteta im. A.I. Evdokimova, Moskva
Shikh E.V.
Kafedra klinicheskoĭ farmakologii i propedevtiki vnutrennikh bolezneĭ GBOU VPO "Pervyĭ Moskovskiĭ gosudarstvennyĭ meditsinskiĭ universitet im. I.M. Sechenova"
Rebrova E.V.
Department of Clinical Pharmacology and Propaedeutics of Internal Diseases, Faculty of Medicine, I.M. Sechenov First Moscow State Medical University, Ministry of Health of Russia, Moscow, Russia, 119991
Ryazanova A.Yu.
Russian Clinical and Research Center of Gerontology, Moscow, Russia, 129226 ,Department of Clinical Pharmacology and Intensive Therapy with the course of clinical pharmacology of CVF, clinical allergology of the Volgograd State Medical University, Volgograd, Russia, 400131
List of references:
Close metadata
Email Confirmation
An email was sent to test@gmail.com with a confirmation link. Follow the link from the letter to complete the registration on the site.
Email Confirmation
Log in to the site using your account in one of the services
We use cооkies to improve the performance of the site. By staying on our site, you agree to the terms of use of cооkies. To view our Privacy and Cookie Policy, please. click here.