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Matveeva N.Iu.

Otdelenie funktsional'noĭ diagnostiki Tsentral'nogo instituta travmatologii i ortopedii im. N.N. Priorova

Pavlush D.G.

Pacific State Medical University of the Ministry of Health of Russia, Vladivostok, Russia

Kalinichenko S.G.

Pacific State Medical University, Vladivostok, Russia

Expression of pro- and anti-apoptotic molecules in the mucous membrane of the nasal cavity with polypous rhinosinusitis

Authors:

Matveeva N.Iu., Pavlush D.G., Kalinichenko S.G.

More about the authors

Journal: Russian Bulletin of Otorhinolaryngology. 2020;85(3): 43‑47

DOI: 10.17116/otorino20208503143

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Table of contents

EXPRESSION OF PRO- AND ANTI-APOPTOTIC MOLECULES IN THE MUCOUS MEMBRANE OF THE NASAL CAVITY WITH POLYPOUS RHINOSINUSITIS
EXPRESSION OF PRO- AND ANTI-APOPTOTIC MOLECULES IN THE MUCOUS MEMBRANE OF THE NASAL CAVITY WITH POLYPOUS RHINOSINUSITIS

To cite this article:

Matveeva NIu, Pavlush DG, Kalinichenko SG. Expression of pro- and anti-apoptotic molecules in the mucous membrane of the nasal cavity with polypous rhinosinusitis. Russian Bulletin of Otorhinolaryngology. 2020;85(3):43‑47. (In Russ.)
https://doi.org/10.17116/otorino20208503143

Подписка 2025-2 (Russian Bulletin of Otorhinolaryngology)
 
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Objective. To study the expression of proapoptotic (p53, p21) and antiapoptotic (MDM2) factors, as well as the distribution of proliferating PCNA-immunoreactive cells in the nasal mucosa in various types of polyposis rhinosinusitis (PRS). Material and methods. We studied the immunolocalization of proapoptotic (p53, p21) and antiapoptotic (MDM2) factors, as well as the distribution of proliferating PCNA immunoreactive cells in the mucous membrane of the nasal cavity for various types of polypous rhinosinusitis. Results and discussion. Comparing with the control group, increased expression of all factors is detected. The main portion of marked cells is located in the loose connective tissue of the lamina propria of mucous membrane, a relatively small number of cells are detected in the epithelial layer. The edematous, eosinophilic (allergic) type of PRS is characterized by the expression of p53 and PCNA and by the reduction of MDM2 immunoreactive cells, while the expression of p53 and p21 is reduced in fibroinflammatory (neutrophilic) type. Conclusion. PRS is accompanied by epithelial metaplasia, by formation of inflammatory cell infiltrates, fibrosis and edema. The results are discussed in connection with the data on the regulatory role of apoptosis in the pathomorphism of chronic productive inflammation.

Keywords:

productive mucosal inflammation
metaplasia
apoptosis
p53
p21
MDM2
PCNA

Authors:

Matveeva N.Iu.

Otdelenie funktsional'noĭ diagnostiki Tsentral'nogo instituta travmatologii i ortopedii im. N.N. Priorova

Pavlush D.G.

Pacific State Medical University of the Ministry of Health of Russia, Vladivostok, Russia

Kalinichenko S.G.

Pacific State Medical University, Vladivostok, Russia

List of references:

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  2. Pawankar R, Nonaka M. Inflammatory mechanisms in chronic rhinosinusitis and nasal polyps. Curr Allergy Asthma Rep. 2007; 7(3):202-208. https://doi.org/10.1007/s11882-007-0073-4
  3. Meng J, Zhou P, Liu Y, Liu F, Yi X, Liu S, et al. The development of nasal polyp disease involves early nasal mucosal inflammation and remodeling. PLoS One. 2013;8(12):82373. Published online 2013 Dec 10. https://doi.org/10.1371/journal.pone.0082373
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  8. Matveeva NYu, Matveev YuA, Kalinichenko SG, Edranov SS, Kaminsky YuV. The role of apoptosis of enterocytes in inflammatory bowel diseases. Byulleten sibirskoj meditsiny. 2018;17(1):121-130. (In Russ.) https://doi.org/10.20538/1682-0363-2018-1-121-129
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  13. Kalinichenko SG, Matveeva NYu. Morphological characteristic of apoptosis and its significance in neurogenesis. Morfologiya. 2007;131(2):16-28. (In Russ.)
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