Expression of pro- and anti-apoptotic molecules in the mucous membrane of the nasal cavity with polypous rhinosinusitis

The site of the Media Sphera Publishers contains materials intended solely for healthcare professionals.
By closing this message, you confirm that you are a certified medical professional or a student of a medical educational institution.

Search result: 0

Matveeva N.Iu.

Otdelenie funktsional'noĭ diagnostiki Tsentral'nogo instituta travmatologii i ortopedii im. N.N. Priorova

Pavlush D.G.

Pacific State Medical University of the Ministry of Health of Russia, Vladivostok, Russia

Kalinichenko S.G.

Pacific State Medical University, Vladivostok, Russia

Expression of pro- and anti-apoptotic molecules in the mucous membrane of the nasal cavity with polypous rhinosinusitis

Authors:

Matveeva N.Iu., Pavlush D.G., Kalinichenko S.G.

More about the authors

Journal: Russian Bulletin of Otorhinolaryngology. 2020;85(3): 43‑47

DOI: 10.17116/otorino20208503143

Read: 1642 times

Download PDF (RU)

Contact the author

Table of contents

To cite this article:

Matveeva NIu, Pavlush DG, Kalinichenko SG. Expression of pro- and anti-apoptotic molecules in the mucous membrane of the nasal cavity with polypous rhinosinusitis. Russian Bulletin of Otorhinolaryngology. 2020;85(3):43‑47. (In Russ.)
https://doi.org/10.17116/otorino20208503143

Подписка 2026 Вестник оториноларингологии (Russian Bulletin of Otorhinolaryngology)

Использование инфографики авторами научных работ

Close metadata

Recommended articles:

Morphogenesis and molecular regulation of polyposis rhinosinusitis. Russian Journal of Archive of Pathology. 2025;(1):68-76

Abstract:

Objective. To study the expression of proapoptotic (p53, p21) and antiapoptotic (MDM2) factors, as well as the distribution of proliferating PCNA-immunoreactive cells in the nasal mucosa in various types of polyposis rhinosinusitis (PRS). Material and methods. We studied the immunolocalization of proapoptotic (p53, p21) and antiapoptotic (MDM2) factors, as well as the distribution of proliferating PCNA immunoreactive cells in the mucous membrane of the nasal cavity for various types of polypous rhinosinusitis. Results and discussion. Comparing with the control group, increased expression of all factors is detected. The main portion of marked cells is located in the loose connective tissue of the lamina propria of mucous membrane, a relatively small number of cells are detected in the epithelial layer. The edematous, eosinophilic (allergic) type of PRS is characterized by the expression of p53 and PCNA and by the reduction of MDM2 immunoreactive cells, while the expression of p53 and p21 is reduced in fibroinflammatory (neutrophilic) type. Conclusion. PRS is accompanied by epithelial metaplasia, by formation of inflammatory cell infiltrates, fibrosis and edema. The results are discussed in connection with the data on the regulatory role of apoptosis in the pathomorphism of chronic productive inflammation.

Keywords:

productive mucosal inflammation

metaplasia

apoptosis

p53

p21

MDM2

PCNA

Authors:

Matveeva N.Iu.

Otdelenie funktsional'noĭ diagnostiki Tsentral'nogo instituta travmatologii i ortopedii im. N.N. Priorova

Pavlush D.G.

Pacific State Medical University of the Ministry of Health of Russia, Vladivostok, Russia

Kalinichenko S.G.

Pacific State Medical University, Vladivostok, Russia

Close metadata

References:

Pavlush DG, Pavlush EN, Matveeva NYu, Kalinichenko SG, Dyuyzen IV. Chronic polyposis rhinosinusitis: etiopathogenetic mechanisms of its occurrence. Medicina. 2018;6(2):69-78. (In Russ.)
Pawankar R, Nonaka M. Inflammatory mechanisms in chronic rhinosinusitis and nasal polyps. Curr Allergy Asthma Rep. 2007; 7(3):202-208. https://doi.org/10.1007/s11882-007-0073-4
Meng J, Zhou P, Liu Y, Liu F, Yi X, Liu S, et al. The development of nasal polyp disease involves early nasal mucosal inflammation and remodeling. PLoS One. 2013;8(12):82373. Published online 2013 Dec 10. https://doi.org/10.1371/journal.pone.0082373
Uller L, Andersson M, Greiff L, Persson CGA, Erjefält JS. Occurrence of apoptosis, secondary necrosis, and cytolysis in eosinophilic nasal polyps. Am J Respir Crit Care Med. 2004;170(7):742-747. https://doi.org/10.1164/rccm.200402-240oc
Zavadsky AV, Zavadsky NV. Nasal polyps cytology and its relation to diseases pathogenesis. Zhurnal vushnikh, nosovikh і gorlovikh khvorob. 2011;1:8-17. (In Russ.)
Hellquist HB. Nasal polyps update. Histopathology. Allergy Asthma Proc. 1996;17(5):237-242.
Garavello W, Viganò P, Romagnoli M, Sordo L, Berti E, Tredici G, et al. Expression of cell cycle regulatory proteins and analysis of apoptosis in normal nasal mucosa and in nasal polyps. Am J Rhinol. 2005;19(6):549-553. https://doi.org/10.1177/194589240501900603
Matveeva NYu, Matveev YuA, Kalinichenko SG, Edranov SS, Kaminsky YuV. The role of apoptosis of enterocytes in inflammatory bowel diseases. Byulleten sibirskoj meditsiny. 2018;17(1):121-130. (In Russ.) https://doi.org/10.20538/1682-0363-2018-1-121-129
Haanen С, Vermes I. Apoptosis and inflammation. Mediators of Inflammation. 1995;4:5-15. https://doi.org/10.3109/03009741003742771
Dubikov AI, Kalinichenko SG. Small molecules regulating apoptosis in the synovium in rheumatoid arthritis. Scand J Rheumatol. 2010;39(5):368-372. https://doi:10.3109/03009741003742771
Henson PM, Bratton DL. Antiinflammatory effects of apoptotic cells. J Clin Invest. 2013;123(7):2773-2774. https://doi.org/10.1172/JCI69344
Matveeva NYu, Kalinichenko SG, Edranov SS. Morphofunctional parameters of retinal ganglion cells and their features in the openangle glaucoma. Tikhookeanskij meditsinskij zhurnal. 2015;3:6-10. (In Russ.)
Kalinichenko SG, Matveeva NYu. Morphological characteristic of apoptosis and its significance in neurogenesis. Morfologiya. 2007;131(2):16-28. (In Russ.)
Matveeva NYu. Apoptosis: morphologic features and molecular mechanisms. Tikhookeanskij meditsinskij zhurnal. 2003;4:12-16. (In Russ.)
Galvão dos Anjos CP, Vasconcelos AC, Tormin Borges Crosara PF, Coelho dos Anjos G, Becker CG, Santos Guimarães RE. Apoptosis in eosinophilic nasal polyps treated in vitro with Mitomycin C. Braz J Otorhinolaryngol. 2012;78(3):32-37. https://doi.org/10.1590/S1808-86942012000300007
Davidsson A, Anderson T, Hellquist HB. Apoptosis and phagocytosis of tissue-dwelling eosinophils in sinonasal polyps. Laryngoscope. 2000;110:111-116. https://doi.org/10.1097/00005537-200001000-00020
Küpper DS, Valera FC, Malinsky R, Milanezi CM, Silva JS, Tamashiro E, et al. Expression of apoptosis mediators p53 and caspase 3, 7, and 9 in chronic rhinosinusitis with nasal polyposis. Am J Rhinol Allergy. 2014;28(3):187-191. https://doi.org/10.2500/ajra.2014.28.4022
Kiselev VI, Paltsev MA. Regulation of gene activity and new drugs. Vestnik Rossijskoj akademii nauk. 2016;86(6):512-518. (In Russ.) https://doi.org/10.7868/S0869587316060116

Log in to the site using your account in one of the services

Registration

Last Name

Name

Middle Name

E-mail

Phone

Address

Country

Zip

City

Region

Street

Home

Apartmen

Legal entity name

ИНН

КПП

Password

Password

Repeat password

We use cооkies to improve the performance of the site. By staying on our site, you agree to the terms of use of cооkies. To view our Privacy and Cookie Policy, please. click here.