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Mironovich O.L.

Federal State Budgetary Institution «Research Centre for Medical Genetics», Moscow, Russia, 115478

Bliznetz E.A.

Research Centre for Medical Genetics, Moscow, Russia

Garbaruk E.S.

Laboratory of Hearing and Speech, Academician I.P. Pavlov First Saint-Petersburg State Medical University, Saint-Petersburg, Russia, 197022

Belogurova M.B.

Saint Petersburg State Pediatric Medical University, Saint Petersburg, Russia, 194100;
N.N. Petrov Research Institute of Oncology, Saint Petersburg, Russia, 197758

Subora N.V.

N.N. Petrov Research Institute of Oncology, Saint Petersburg, Russia, 197758

Varfolomeyeva S.R.

Dmitry Rogachev National Research and Practical Center for Pediatric Hematology, Oncology and Immunology, Moscow, Russia

Kachanov D.Yu.

Dmitry Rogachev National Research and Practical Center for Pediatric Hematology, Oncology and Immunology, Moscow, Russia

Shamanskaya T.V.

Dmitry Rogachev Federal Scientific of Hematology, Oncology and Immunology, Moscow, Russia

Markova T.G.

FGU "Rossiĭskiĭ nauchno-prakticheskiĭ tsentr audiologii i slukhoprotezirovaniia"

Poliakov A.V.

Mediko-geneticheskiĭ nauchnyĭ tsentr RAMN, Moskva

The analysis of the association of the polymorphic variants of the TPMT, COMT, and ABCC3 genes with the development of hearing disorders induced by the cisplatin treatment

Authors:

Mironovich O.L., Bliznetz E.A., Garbaruk E.S., Belogurova M.B., Subora N.V., Varfolomeyeva S.R., Kachanov D.Yu., Shamanskaya T.V., Markova T.G., Poliakov A.V.

More about the authors

Journal: Russian Bulletin of Otorhinolaryngology. 2018;83(4): 60‑66

DOI: 10.17116/otorino201883460

Views: 807

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To cite this article:

Mironovich OL, Bliznetz EA, Garbaruk ES, et al. . The analysis of the association of the polymorphic variants of the TPMT, COMT, and ABCC3 genes with the development of hearing disorders induced by the cisplatin treatment. Russian Bulletin of Otorhinolaryngology. 2018;83(4):60‑66. (In Russ.)
https://doi.org/10.17116/otorino201883460

Подписка 2025 (Russian Bulletin of Otorhinolaryngology)
 
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Cisplatin and its derivatives are widely used chemotherapeutic agents for the treatment of many cancers, including hepatoblastoma, brain tumors, and germ-cell tumors. This therapy contributed to the dramatic increase in the survival rate. However, its use is restricted by the high incidence of irreversible ototoxicity associated with cisplatin application (in more than 60% of the children receiving it). Some studies have reported that genetic variants of TPMT (rs 12201199), COMT (rs4646316), and ABCC3 (rs 1051640) are conferring increased risk of developing cisplatin-induced hearing loss. However, in other studies the results were not replicated. In the present study, we replicated the previous studies based on an independent cohort of Russian patients. SNP genotypes for rs 12201199, rs4646316 and rs 1051640 were determined in DNA samples obtained from 16 patients who developed hearing loss and a group of 34 patients whose hearing was retained. The association between TPMT (rs 12201199), COMT (rs4646316), and ABCC3 (rs 1051640) variants and the hearing loss was not observed in our cohort.

Keywords:

cisplatin
ototoxicirty
TPMT
COMT
ABCC3

Authors:

Mironovich O.L.

Federal State Budgetary Institution «Research Centre for Medical Genetics», Moscow, Russia, 115478

Bliznetz E.A.

Research Centre for Medical Genetics, Moscow, Russia

Garbaruk E.S.

Laboratory of Hearing and Speech, Academician I.P. Pavlov First Saint-Petersburg State Medical University, Saint-Petersburg, Russia, 197022

Belogurova M.B.

Saint Petersburg State Pediatric Medical University, Saint Petersburg, Russia, 194100;
N.N. Petrov Research Institute of Oncology, Saint Petersburg, Russia, 197758

Subora N.V.

N.N. Petrov Research Institute of Oncology, Saint Petersburg, Russia, 197758

Varfolomeyeva S.R.

Dmitry Rogachev National Research and Practical Center for Pediatric Hematology, Oncology and Immunology, Moscow, Russia

Kachanov D.Yu.

Dmitry Rogachev National Research and Practical Center for Pediatric Hematology, Oncology and Immunology, Moscow, Russia

Shamanskaya T.V.

Dmitry Rogachev Federal Scientific of Hematology, Oncology and Immunology, Moscow, Russia

Markova T.G.

FGU "Rossiĭskiĭ nauchno-prakticheskiĭ tsentr audiologii i slukhoprotezirovaniia"

Poliakov A.V.

Mediko-geneticheskiĭ nauchnyĭ tsentr RAMN, Moskva

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