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Sheremet N.L.

Krasnov Research Institute of Eye Diseases

Ronzina I.A.

Research Institute of Eye Diseases

Andreeva N.A.

Research Institute of Eye Diseases

Zhorzholadze N.V.

Research Institute of Eye Diseases

Murakhovskaya Yu.K.

Krasnov Research Institute of Eye Diseases;
Sechenov First Moscow State Medical University

Nevinitsyna T.A.

Research Institute of Eye Diseases

Shmelkova M.S.

Krasnov Research Institute of Eye Diseases

Krylova T.D.

Bochkov Research Centre for Medical Genetics

Tsygankova P.G.

Bochkov Research Center for Medical Genetics

Gerasimidi E.S.

Institute of Mitoengineering of the Lomonosov Moscow State University

Lyamzaev K.G.

Institute of Mitoengineering of the Lomonosov Moscow State University;
A.N. Belozersky Institute of Physico-Chemical Biology of the Lomonosov Moscow State University

Skulachev M.V.

Institute of Mitoengineering of the Lomonosov Moscow State University;
A.N. Belozersky Institute of Physico-Chemical Biology of the Lomonosov Moscow State University

Karger E.M.

Institute of Mitoengineering of the Lomonosov Moscow State University;
A.N. Belozersky Institute of Physico-Chemical Biology of the Lomonosov Moscow State University

Electrophysiological and psychophysical studies in assessment of visual functions in patients with hereditary optic neuropathy

Authors:

Sheremet N.L., Ronzina I.A., Andreeva N.A., Zhorzholadze N.V., Murakhovskaya Yu.K., Nevinitsyna T.A., Shmelkova M.S., Krylova T.D., Tsygankova P.G., Gerasimidi E.S., Lyamzaev K.G., Skulachev M.V., Karger E.M.

More about the authors

Journal: Russian Annals of Ophthalmology. 2022;138(2): 5‑14

DOI: 10.17116/oftalma20221380215

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Table of contents

ELECTROPHYSIOLOGICAL AND PSYCHOPHYSICAL STUDIES IN ASSESSMENT OF VISUAL FUNCTIONS IN PATIENTS WITH HEREDITARY OPTIC NEUROPATHY
ELECTROPHYSIOLOGICAL AND PSYCHOPHYSICAL STUDIES IN ASSESSMENT OF VISUAL FUNCTIONS IN PATIENTS WITH HEREDITARY OPTIC NEUROPATHY

To cite this article:

Sheremet NL, Ronzina IA, Andreeva NA, et al. . Electrophysiological and psychophysical studies in assessment of visual functions in patients with hereditary optic neuropathy. Russian Annals of Ophthalmology. 2022;138(2):5‑14. (In Russ., In Engl.)
https://doi.org/10.17116/oftalma20221380215

Подписка 2026 Вестник офтальмологии (Russian Annals of Ophthalmology)
МСФ на ЯМ
Использование инфографики авторами научных работ
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Abstract:

PURPOSE

To study the capabilities of electrophysiological and psychophysical examination methods for assessment of the functional state of ganglion cells, retina and optic nerve in patients with hereditary optic neuropathy (HON).

MATERIAL AND METHODS

The study included 60 patients (118 eyes) with a genetically confirmed diagnosis of HON. All study patients underwent visual field test (VFT), spectral optical coherence tomography (OCT), flash and pattern visual evoked potentials (VEP) (Flash-VEP, FVEP; Pattern-VEP, PVEP), photopic electroretinography with photonegative response (PhNR) registration and the color vision test. In 24 patients (46 eyes), these parameters were assessed before the start of treatment and one year later. The treatment involved the mitochondria-targeted antioxidant SkQ1 — plastoquinonyl-decyl-triphenylphosphonium bromide (PDTP) in the form of eye drops.

RESULTS

The main PVEP components for 1.0° and 0.3° were registered in 20% and in 14% of patient eyes with HON and high visual functions, respectively. After one year of PDTP use, a significant decrease in P100 peak latency was found only in the group with disease duration of ≤1.5 years as of the time of treatment start (p<0.05). Significant differences were observed in the PhNR amplitude (p<0.004) between patients of the main and the control groups, as well as in the PhNR amplitude between patients with visual acuity of ≤0.1 and ≥0.13 (p<0.01). Patients with high visual functions were found to have a correlation between the PhNR amplitude, GCC thickness and the global loss index (GLV).

CONCLUSION

Along with VFT, OCT and color vision tests, electrophysiological studies are one of the main methods of examining patients with HON. After one year of PDTP use, there was a significant decrease in the FVEP P2 peak latency in the group with a disease duration of ≤1.5 years as of the time of treatment start. The PhNR amplitude in patients with high visual functions was found to correlate with structural changes in the ganglion cell layer and the retinal nerve fiber layer.

Keywords:

Leber’s hereditary optic neuropathy
retinal ganglion cells
visual evoked potentials
photopic negative response
mitochondria-targeted antioxidant
SkQ1
plastoquinonyl-decyl-triphenylphosphonium bromide

Authors:

Sheremet N.L.

Krasnov Research Institute of Eye Diseases

Ronzina I.A.

Research Institute of Eye Diseases

Andreeva N.A.

Research Institute of Eye Diseases

Zhorzholadze N.V.

Research Institute of Eye Diseases

Murakhovskaya Yu.K.

Krasnov Research Institute of Eye Diseases;
Sechenov First Moscow State Medical University

Nevinitsyna T.A.

Research Institute of Eye Diseases

Shmelkova M.S.

Krasnov Research Institute of Eye Diseases

Krylova T.D.

Bochkov Research Centre for Medical Genetics

Tsygankova P.G.

Bochkov Research Center for Medical Genetics

Gerasimidi E.S.

Institute of Mitoengineering of the Lomonosov Moscow State University

Lyamzaev K.G.

Institute of Mitoengineering of the Lomonosov Moscow State University;
A.N. Belozersky Institute of Physico-Chemical Biology of the Lomonosov Moscow State University

Skulachev M.V.

Institute of Mitoengineering of the Lomonosov Moscow State University;
A.N. Belozersky Institute of Physico-Chemical Biology of the Lomonosov Moscow State University

Karger E.M.

Institute of Mitoengineering of the Lomonosov Moscow State University;
A.N. Belozersky Institute of Physico-Chemical Biology of the Lomonosov Moscow State University

Received:

25.05.2021

Accepted:

30.11.2021

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