The site of the Media Sphera Publishers contains materials intended solely for healthcare professionals.
By closing this message, you confirm that you are a certified medical professional or a student of a medical educational institution.

Login
EN
+7 (495) 482-4118
+7 (495) 482-0604
+8 800 101-59-87
  • (toll-free number for subscriptions)
    Mon-Fri from 10 a.m. to 6 p.m.

  • © 1998-2025
+7 (495) 482-43-29
EN
All journals
Journal
Year
Year
Search result: 0

Sheremet N.L.

Krasnov Research Institute of Eye Diseases

Ronzina I.A.

Research Institute of Eye Diseases

Andreeva N.A.

Research Institute of Eye Diseases

Zhorzholadze N.V.

Research Institute of Eye Diseases

Murakhovskaya Yu.K.

Krasnov Research Institute of Eye Diseases;
Sechenov First Moscow State Medical University

Nevinitsyna T.A.

Research Institute of Eye Diseases

Shmelkova M.S.

Krasnov Research Institute of Eye Diseases

Krylova T.D.

Bochkov Research Centre for Medical Genetics

Tsygankova P.G.

Bochkov Research Center for Medical Genetics

Gerasimidi E.S.

Institute of Mitoengineering of the Lomonosov Moscow State University

Lyamzaev K.G.

Institute of Mitoengineering of the Lomonosov Moscow State University;
A.N. Belozersky Institute of Physico-Chemical Biology of the Lomonosov Moscow State University

Skulachev M.V.

Institute of Mitoengineering of the Lomonosov Moscow State University;
A.N. Belozersky Institute of Physico-Chemical Biology of the Lomonosov Moscow State University

Karger E.M.

Institute of Mitoengineering of the Lomonosov Moscow State University;
A.N. Belozersky Institute of Physico-Chemical Biology of the Lomonosov Moscow State University

Electrophysiological and psychophysical studies in assessment of visual functions in patients with hereditary optic neuropathy

Authors:

Sheremet N.L., Ronzina I.A., Andreeva N.A., Zhorzholadze N.V., Murakhovskaya Yu.K., Nevinitsyna T.A., Shmelkova M.S., Krylova T.D., Tsygankova P.G., Gerasimidi E.S., Lyamzaev K.G., Skulachev M.V., Karger E.M.

More about the authors

Journal: Russian Annals of Ophthalmology. 2022;138(2): 5‑14

DOI: 10.17116/oftalma20221380215

Views: 1662

Downloaded: 50

Download PDF (RU)
Download PDF
Contact the author
Table of contents

To cite this article:

Sheremet NL, Ronzina IA, Andreeva NA, et al. . Electrophysiological and psychophysical studies in assessment of visual functions in patients with hereditary optic neuropathy. Russian Annals of Ophthalmology. 2022;138(2):5‑14. (In Russ., In Engl.)
https://doi.org/10.17116/oftalma20221380215

Подписка 2025 (Russian Annals of Ophthalmology)
 
МСФ на ЯМ
Close metadata
Recommended articles:
Long-term changes in morphological and functional para­meters of the optic nerve in patients with various gene­tic variants of here­ditary optic neuropathies. Russian Annals of Ophthalmology. 2023;(6):77-86
Poly­morphism and modern diagnostic approaches for Leber congenital amaurosis. Russian Annals of Ophthalmology. 2024;(5):56-62
Anatomo-functional state of the central retina in premature infa­nts with intraventricular hemo­rrhage and reti­nopathy of prematurity. S.S. Korsakov Journal of Neurology and Psychiatry. 2024;(1):66-75

PURPOSE

To study the capabilities of electrophysiological and psychophysical examination methods for assessment of the functional state of ganglion cells, retina and optic nerve in patients with hereditary optic neuropathy (HON).

MATERIAL AND METHODS

The study included 60 patients (118 eyes) with a genetically confirmed diagnosis of HON. All study patients underwent visual field test (VFT), spectral optical coherence tomography (OCT), flash and pattern visual evoked potentials (VEP) (Flash-VEP, FVEP; Pattern-VEP, PVEP), photopic electroretinography with photonegative response (PhNR) registration and the color vision test. In 24 patients (46 eyes), these parameters were assessed before the start of treatment and one year later. The treatment involved the mitochondria-targeted antioxidant SkQ1 — plastoquinonyl-decyl-triphenylphosphonium bromide (PDTP) in the form of eye drops.

RESULTS

The main PVEP components for 1.0° and 0.3° were registered in 20% and in 14% of patient eyes with HON and high visual functions, respectively. After one year of PDTP use, a significant decrease in P100 peak latency was found only in the group with disease duration of ≤1.5 years as of the time of treatment start (p<0.05). Significant differences were observed in the PhNR amplitude (p<0.004) between patients of the main and the control groups, as well as in the PhNR amplitude between patients with visual acuity of ≤0.1 and ≥0.13 (p<0.01). Patients with high visual functions were found to have a correlation between the PhNR amplitude, GCC thickness and the global loss index (GLV).

CONCLUSION

Along with VFT, OCT and color vision tests, electrophysiological studies are one of the main methods of examining patients with HON. After one year of PDTP use, there was a significant decrease in the FVEP P2 peak latency in the group with a disease duration of ≤1.5 years as of the time of treatment start. The PhNR amplitude in patients with high visual functions was found to correlate with structural changes in the ganglion cell layer and the retinal nerve fiber layer.

Keywords:

Leber’s hereditary optic neuropathy
retinal ganglion cells
visual evoked potentials
photopic negative response
mitochondria-targeted antioxidant
SkQ1
plastoquinonyl-decyl-triphenylphosphonium bromide

Authors:

Sheremet N.L.

Krasnov Research Institute of Eye Diseases

Ronzina I.A.

Research Institute of Eye Diseases

Andreeva N.A.

Research Institute of Eye Diseases

Zhorzholadze N.V.

Research Institute of Eye Diseases

Murakhovskaya Yu.K.

Krasnov Research Institute of Eye Diseases;
Sechenov First Moscow State Medical University

Nevinitsyna T.A.

Research Institute of Eye Diseases

Shmelkova M.S.

Krasnov Research Institute of Eye Diseases

Krylova T.D.

Bochkov Research Centre for Medical Genetics

Tsygankova P.G.

Bochkov Research Center for Medical Genetics

Gerasimidi E.S.

Institute of Mitoengineering of the Lomonosov Moscow State University

Lyamzaev K.G.

Institute of Mitoengineering of the Lomonosov Moscow State University;
A.N. Belozersky Institute of Physico-Chemical Biology of the Lomonosov Moscow State University

Skulachev M.V.

Institute of Mitoengineering of the Lomonosov Moscow State University;
A.N. Belozersky Institute of Physico-Chemical Biology of the Lomonosov Moscow State University

Karger E.M.

Institute of Mitoengineering of the Lomonosov Moscow State University;
A.N. Belozersky Institute of Physico-Chemical Biology of the Lomonosov Moscow State University

Received:

25.05.2021

Accepted:

30.11.2021

List of references:

  1. Jornayvaz FR, Shulman GI. Regulation of mitochondrial biogenesis. Essays Biochem. 2010;47:69-84.  https://doi.org/10.1042/bse0470069
  2. Machida S. Clinical Applications of the Photopic Negative Response to Optic Nerve and Retinal Diseases. J Ophthalmol. 2012;2012:397178. https://doi.org/10.1155/2012/397178
  3. Botelho GIS, Salomão SR, Tengan CH, Karanjia R, Moura FV, Rocha DM, da Silva PBE, Fernandes AG, Watanabe SES, Sacai PY, Belfort R Jr, Carelli V, Sadun AA, Berezovsky A. Impaired Ganglion Cell Function Objectively Assessed by the Photopic Negative Response in Affected and Asymptomatic Members From Brazilian Families With Leber’s Hereditary Optic Neuropathy. Front Neurol. 2021;11:628014. https://doi.org/10.3389/fneur.2020.628014
  4. Kulybysheva VS, Ronzina IA, Gamidov AA. Neurodegenerative changes of the retina in patients with diabetes. The Russian Annals of Ophthalmology = Vestnik oftal’mologii. 2019;135(5):31-37. (In Russ.). https://doi.org/10.17116/oftalma201913505131
  5. Kurysheva NI, Maslova EV, Trubilina AV, Fomin AV, Lagutin MB. Pattern visual evoked potentials and their relation to the peripapillary and retrobulbar blood flow in glaucoma. The Russian Annals of Ophthalmology = Vestnik oftal’mologii. 2018;134(3):19-27. (In Russ.). https://doi.org/10.17116/oftalma2018134319
  6. Konikova OA, Brzhesky VV. Electrophysiological characteristics of the retina in children with cicatrical retinopathy of prematurity. The Russian Annals of Ophthalmology = Vestnik oftal’mologii. 2018;134(1):12-17. (In Russ.). https://doi.org/10.17116/oftalma2018134112-17
  7. Hwang TJ, Karanjia R, Moraes-Filho MN, Gale J, Tran JS, Chu ER, Salomao SR, Berezovsky A, Belfort R Jr, Moraes MN, Sadun F, DeNegri AM, La Morgia C, Barboni P, Ramos CDVF, Chicani CF, Quiros PA, Carelli V, Sadun AA. Natural History of Conversion of Leber’s Hereditary Optic Neuropathy: A Prospective Case Series. Ophthalmology. 2017;124(6):843-850.  https://doi.org/10.1016/j.ophtha.2017.01.002
  8. Viswanathan S, Frishman LJ, Robson JG, Harwerth RS, Smith EL 3rd. The photopic negative response of the macaque electroretinogram: reduction by experimental glaucoma. Invest Ophthalmol Vis Sci. 1999;40(6):1124-1136. https://pubmed.ncbi.nlm.nih.gov/10235545/
  9. Spileers W, Falcao-Reis F, Smith R, Hogg C, Arden G. The human ERG evoked by a ganzfeld stimulator powered by red and green light emitting diodes. Clin Vision Sci. 1993;8:21-39.  https://lirias.kuleuven.be/1130828?limo=0
  10. ElGohary AA, Elshazly LH. Photopic negative response in diagnosis of glaucoma: an experimental study in glaucomatous rabbit model. Int J Ophthalmol. 2015;8(3):459-464.  https://doi.org/10.3980/j.issn.2222-3959.2015.03.05
  11. Prencipe M, Perossini T, Brancoli G, Perossini M. The photopic negative response (PhNR): measurement approaches and utility in glaucoma. Int Ophthalmol. 2020;40:3565-3576. https://doi.org/10.1007/s10792-020-01515-0
  12. Wakili N, Horn FK, Jünemann AG, Nguyen NX, Mardin CY, Korth M, Kremers J. The photopic negative response of the blue-on-yellow flash-electroretinogram in glaucomas and normal subjects. Doc Ophthalmol. 2008; 117(2):147-154.  https://doi.org/10.1007/s10633-008-9116-y
  13. Tamada K, Machida S, Yokoyama D, Kurosaka D. Photopic negative response of full-field and focal macular electroretinograms in patients with optic nerve atrophy. Jpn J Ophthalmol. 2009;53(6):608-614.  https://doi.org/10.1007/s10384-009-0731-2
  14. Park JC, Moss HE, McAnany JJ. Electroretinography in idiopathic intracranial hypertension: comparison of the pattern ERG and the photopic negative response. Doc Ophthalmol. 2018;136(1):45-55.  https://doi.org/10.1007/s10633-017-9620-z
  15. Noma H, Mimura T, Kuse M, Yasuda K, Shimura M. Photopic negative response in branch retinal vein occlusion with macular edema. Intern Ophthalmol. 2015;35(1):19-26.  https://doi.org/10.1007/s10792-014-0012-z
  16. Matsumoto CS, Shinoda K, Yamada K, Nakatsuka K. Photopic negative response reflects severity of ocular circulatory damage after central retinal artery occlusion. Ophthalmologica. 2009;223(6):362-369.  ttpps://doi.org/10.1159/000227782
  17. Park JC, Chau FY, Lim JI, McAnany JJ. Electrophysiological and pupillometric measures of inner retina function in nonproliferative diabetic retinopathy. Doc Ophthalmol. 2019;139(2):99-111.  https://doi.org/10.1007/s10633-019-09699-2
  18. Kim HD, Park JY, Ohn YH. Clinical applications of photopic negative response (PhNR) for the treatment of glaucoma and diabetic retinopathy. Korean J Ophthalmol. 2010;24(2):89-95.  https://doi.org/10.3341/kjo.2010.24.2.89
  19. Majander A, Robson AG, João C, Holder GE, Chinnery PF, Moore AT, Votruba M, Stockman A, Yu-Wai-Man P. The pattern of retinal ganglion cell dysfunction in Leber hereditary optic neuropathy. Mitochondrion. 2017; 36:138-149.  https://doi.org/10.1016/j.mito.2017.07.006
  20. Karanjia R, Berezovsky A, Sacai PY, Cavascan NN, Liu HY, Nazarali S, Moraes-Filho MN, Anderson K, Tran JS, Watanabe SE, Moraes MN, Sadun F, DeNegri AM, Barboni P, do Val Ferreira Ramos C, La Morgia C, Carelli V, Belfort R Jr, Coupland SG, Salomao SR, Sadun AA. The Photopic Negative Response: An Objective Measure of Retinal Ganglion Cell Function in Patients With Leber’s Hereditary Optic Neuropathy. Invest Ophthalmol Vis Sci. 2017;58(6):BIO300-BIO306. https://doi.org/10.1167/iovs.17-21773

Close metadata

Contact the author
Email
Message
The publishing house "Media Sphere" does not provide treatment services, does not give recommendations on contacting medical institutions and specific specialists, on the prescription of medicines and dietary supplements.

Email Confirmation

An email was sent to test@gmail.com with a confirmation link. Follow the link from the letter to complete the registration on the site.

Email Confirmation

Contact us
If you have any questions, complaints or suggestions, please use this feedback form.
Email
Message
The publishing house "Media Sphere" does not provide treatment services, does not give recommendations on contacting medical institutions and specific specialists, on the prescription of medicines and dietary supplements.
Submit Application

You can become an author of one of our magazines, send a request and we will consider it in during the day.

Name
Phone
E-mail
Message
Login
Registration
E-mail
Password
Forgot Password?

Log in to the site using your account in one of the services

Password recovery
E-mail
Login
Register


We use cооkies to improve the performance of the site. By staying on our site, you agree to the terms of use of cооkies. To view our Privacy and Cookie Policy, please. click here.