Possibilities of ultrasound methods in diagnostics of eyelid tumors

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Purpose — to determine the informative value of ultrasound biomicroscopy (UBM) with A-scan for assessment of qualitative and quantitative characteristics of eyelid tumors less than 5 mm in size. Material and methods. The study included 25 patients (25 eyes) with eyelid tumors less than 5 mm in size. In addition to standard ophthalmic examination, complex ultrasound diagnostics including B-scan, Color Doppler imaging and UBM with A-scan were performed. The localization, size, structure of eyelid tumors and the state of perifocal tissues were evaluated. All patients underwent surgical treatment with following histological examinations of dissected tissues. Due to qualitative analysis of the studied formations and small number of included patients, there was no need in statistical analysis of the data. Results. Complex application of UBM and A-scan allowed specifying the localization, size, structure of the small-sized tumors and detecting typical echographic signs of benign or malignant properties of the pathological process. Ultrasound data (UBM and A-scan) of eyelid tumors was highly correlated to histological features. Conclusion. UBM with A-scan can be recommended for differential diagnostics of small-sized tumors and optimizing their management.

Keywords:

ultrasound biomicroscopy

A-scan

small-sized tumor

eyelids

Authors:

Kiseleva T.N.

Department of Ultrasound of Helmholtz Moscow Research Institute of Eye Diseases, Moscow, Russia

Lugovkina K.V.

Helmholtz National Medical Research Center of Eye Diseases, Moscow, Russia

Guseva N.V.

Helmholtz National Medical Research Center of Eye Diseases, Moscow, Russia

Zaitsev M.S.

Helmholtz National Medical Research Center of Eye Diseases, Moscow, Russia

List of references:

Brovkina AF. Oftal’moonkologiya. Rukovodstvo dlya vrachey [Ophthalmooncology. A guide for doctors]. M.: Meditsina; 2002. (In Russ.).
Brovkina AF, Lerner MYu. Skin cancer century: epidemiology, prognosis. Opukholi Golovy i Shei = Head and Neck Tumors. 2017;7(7):81-85. (In Russ.).
Panova IE, Vazhenin AV, Vazhenina DA, Zotova AS, Pavlenko ES. Aspects of diagnosis in patients with malignant pathology of the organ of vision of common stages and generalization of the process in the conditions of the ophthalmic and oncological center. Palliativnaya Meditsina i Reabilitatsiya = Palliative Medicine and Rehabilitation. 2007;(3):24-28. (In Russ.).
Dyad’kin VYu, Shaimov BA, Khalilov BV. Opukholi kozhi melanogennoy prirody: Uchebnoe posobie dlya vrachey [Tumors of the skin of melanogenic nature: A training manual for doctors]. Kazan’: Izdatel’stvo Kazanskiogo GMU; 2014. (In Russ.).
Gel’fond ML. Differential diagnosis of skin tumors in the practice of dermatologists and cosmetologists. Prakticheskaya Onkologiya = Practical Oncology. 2012;13(2):69-79. (In Russ.).
Wang K, Levine A, Markowitz O. Optical coherence tomography for skin cancer. Oncol Times. 2016;38(17):15-16. https://doi.org/10.1016/j.det.2017.06.008
Derpalyuk EN. Vozmozhnosti opticheskoy kogerentnoy tomografii v diagnostike, differentsial’noy diagnostike i opredelenii granits bazal’nokletochnogo raka kozhi: Dis.... kand. med. nauk [Possibilities of optical coherent tomography in the diagnosis, differential diagnosis and determination of the boundaries of basal cell skin cancer. Cand. Diss. (Med. Sci.)]. N. Novgorod. 2006. (In Russ.).
Calin MA, Parasca SV, Savastru R, Calin MR, Dontu S. Optical techniques for the noninvasive diagnosis of skin cancer. J Cancer Res Clin Oncol. 2013;139:1083-1104. https://doi.org/10.1007/s00432-013-1423-3
Dubois A, Levecq O, Azimani H, Perrot JL. Line-field confocal optical coherence tomography for high — resolution noninvasive imaging of skin tumors. J Biomed Opt. 2018;23(10):1-10.
Mogensen M, Joergensen TM, Nurnberg BM, Morsy HA, Thomsen JB, Thrane L, Jemec GB. Assessment of optical coherence tomography imaging in the diagnosis of non-melanoma skin cancer and benign lesions versus normal skin: observer-blinded evaluation by dermatologists and pathologist. Dermatol Surg. 2009;35:965-972.
Garcia-Uribe A, Smith EB, Zou J, Duvic M, Prieto V, Wang LV. In-vivo characterization of optical properties of pigmented skin lesions including melanoma using oblique incidence diffuse reflectance spectrometry. J Biomed Opt. 2011;16(2):020501. https://doi.org/10.1117/1.3536509
Garcia-Uribe A, Zou J, Duvic M, Cho-Vega JH, Prieto VG, Wang LV. In vivo diagnosis of melanoma and nonmelanoma skin cancer using oblique incidence diffuse reflectance spectrometry. Cancer Res. 2012;72:2738-2745. https://doi.org/10.1158/0008-5472.CAN-11-4027
Khristoforova YuA, Bratchenko IA, Artem’eva DN, Myakinina OO, Moryatov AA, Kaganov OI, Kozlov SV, Zakharov VP. Optical diagnosis of malignant and benign skin neoplasms. In: Sbornik trudov III mezhdunarodnoi konferentsii i molodezhnoi shkoly «Informatsionnye tekhnologii i nanotekhnologii» (ITNT-2017) [Collection of works of the III international conference and youth school «Information technology and nanotechnology» (ITNT-2017)]. Samara: Novaya tekhnika; 2017. (In Russ).
Kozlov SV, Zakharov VP, Moryatov AA, Bratchenko IA, Artem’ev DN. The possibilities of raman spectroscopy for the differential diagnosis of skin neoplasms. Izvestiya Samarskogo Nauchnogo Tsentra Rossiyskoy Akademii Nauk. Sotsial’nye, Gumanitarnye, Mediko-Biologicheskie Nauki = News of the Samara Scientific Center of the Russian Academy of Sciences. Social, Humanitarian, Biomedical Sciences. 2015;17(2-3):542-547. (In Russ.).
Lin MJ, Mar V, McLean C, Wolfe R, Kelly JW. Diagnostic accuracy of malignant melanoma according to subtype. Austral J Dermatol. 2012;55(1):35-42. https://doi.org/10.1111/ajd.12121
Novikov IA, Grusha YaO, Kiryushchenkova NP. Improving the efficiency of fluorescence diagnosis of neoplasms of the skin and mucous membranes in ophthalmology. Vestnik Rossijskoj Akademii Medicinskih Nauk = Bulletin of the Russian Academy of Medical Sciences. 2012;(10):62-70. (In Russ.).
Novikov IA, Grusha YaO, Kiryushchenkova NP. Autofluorescence diagnosis of neoplasms of the skin and mucous membranes. Vestnik Oftal’mologii = Russian Annals of Ophthalmology. 2013;129(5):147-153. (In Russ.).
Indilova NI, Yurchenko AI, Kuz’mina TS, Potekaev NN, Tkachenko SB, Chervonnaya LV, Kolobyakov AA. Modern possibilities of complex diagnosis of basal cell skin cancer. Eksperimental’naya i Klinicheskaya Dermatokosmetologiya = Experimental and Clinical Dermatology and Cosmetology. 2010; (2):10-15. (In Russ.).
Kiseleva TN, Kataev MG, Il’ina NV, Zakharova MA, Ramazanova KA. Ultrasound scan method in the assessment of eyelids. Vestnik Oftal’mologii = Russian Annals of Ophthalmology. 2014;(1):46-51 (In Russ.).
Vasilevskaya EA, Ivanova EV, Kuz’mina TS. The use of high-frequency ultrasound equipment for the study of the skin in health and disease. Eksperimental’naya i Klinicheskaya Dermatokosmetologiya = Experimental and Clinical Dermatology and Cosmetology. 2005;(1):33-37 (In Russ.).
Lukasheva NN, Tkachenko SB, Potekaev NN, Kuz’mina TS, Vasilevskaya EA. Intravital reflective confocal laser scanning microscopy: history of creation, principle of operation, possibilities of application in dermatology. Klinicheskaya Dermatologiya i Venerologiya = Clinical Dermatology and Venereology. 2008;(5):10-15. (In Russ.).
Il’ina NV. Comprehensive ultrasound in the diagnosis of pathological conditions of the eyelids and periorbital area. Meditsinskaya Vizualizatsiya = Medical Imaging. 2014;(3):51-58. (In Russ.).
Avetisov SE, Ambartsumyan AR. Ultrasound visualization of the anatomical structures of the eyelids with high-frequency biomicroscopy. Prakticheskaya Meditsina = Practical Medicine. 2012;59(4):233-236. (In Russ.).
Byrne S.F, Green RL. Ultrasound of the eye and orbit. Philadelphia, USA: Mosby Inc.; 2002.
Vasil’chenko SA, Tone NV, Kostenko LV, Burkov SG. Ultrasound diagnosis of skin tumors in planning the scope of surgery. SonoAce Ultrasound. 2012;24:75-81 (In Russ.).
Kuryshova MI. Sonographic characteristics of melanocytic formations of the skin. In: Materialy konferentsii molodykh uchenykh. FGBU «Rostovskii nauchno-issledovatel’skii onkologicheskii institut» Minzdrava Rossii [Materials of the conference of young scientists. Federal State Budgetary Institution «Rostov Research Cancer Institute» of the Ministry of Health of Russia]. Rostov-on-Don; 2015. (In Russ.).
Maksimova NA, Pozdnyakova VV, Kuryshova MI, Il’chenko MG. Ultrasound diagnosis of melanocytic skin lesions. Sovremennye Problemy Nauki i Obrazovaniya = Modern Problems of Science and Education. 2015;(3):57-64. (In Russ.).
Jasaitiene D, Valiukeviciene S, Linkeviciute G, Raisutis R, Jasiuniene E, Kazys R. Principles of high-frequency ultrasonography for investigation of skin pathology. J Eur Acad Dermatol Venereol. 2011;25(4):375-382. https://doi.org/10.1111/j.1468-3083.2010.03837.x
Hayashi K, Koga H, Uhara H, Saida T. High-frequency 30-MHz sonography in preoperative assessment of tumor thickness of primary melanoma: usefulness in determination of surgical margin and indication for sentinel lymph node biopsy. Int J Clin Oncol. 2009;14(5):426-430. https://doi.org/10.1007/s10147-009-0894-3
Demirci H, Nelson CC. Ultrasound biomicroscopy of the upper eyelid structures in normal eyelids. Ophtalm Plast Reconstruct Surg. 2007;23(1):122-125. https://doi.org/10.1097/IOP.0b013e31802f2074
Kikkawa DO, Ochabski R, Weinreb RN. Ultrasound biomicroscopy of eyelids lesions. Ophtalmologica. 2003;217:20023. https://doi.org/10.1159/000068253
Futura M, Shields CL, Danzing CJ, Eagle RC, Shields JA. Ultrasound biomicroscopy of eyelid eccrine hidrocystoma. Can J Ophthalmol. 2007;42(5): 750-751. https://doi.org/10.3129/i07-117
Hinz T, Ehler LK, Hornung T, Voth H, Fortmeier I, Maier T, Höller T, Schmid-Wendtner MH. Preoperative characterization of basal cell carcinoma comparing tumour thickness measurement by optical coherence tomography, 20-MHz ultrasound and histopathology. Acta Derm Venereol. 2011;92(2): 132-137.

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