Introduction. Congenital and acquired diseases, as well as traumatic injuries of the sclera and tarsal plate can lead to serious complications up to the complete loss of visual functions and loss of the eye as an organ if not treated timely. Due to that, it becomes necessary to use biological and synthetic materials during reconstructive and regenerative surgeries to replace the defects and reinforce the carcass properties of the sclera and tarsal plate. Purpose – to compare experimental and morphological features of the response of the eye and surrounding tissues to implantation of the synthetic polymeric implant for reconstructive and regenerative surgery (PERRS) “Reperen-6” and biological xenopericardium implant taken from cattle on the sclera in animal experiment. Material and methods. The studies were conducted on 12 chinchilla rabbits. PERRS “Reperen-6” was implanted on the surface of the sclera (into the subtenon space) of left eyes of 6 rabbits from the main group. Similar surgeries with biological xenopericardium implant taken from cattle were performed on the left eyes of 6 rabbits from the comparison group. The right eyes of each animal from both groups remained intact. After the surgery, we performed examination of the animals and acquisition of the material (the eyes and surrounding tissue) in 16, 34 and 68 days. Enucleated eyes were fixed in 10% buffered formalin solution with subsequent preparation of histologic specimen according to standard procedure. Conclusions. The experimental and morphological studies showed that the postoperative period went smoother in the main group of animals. Thanks to its structure, PERRS “Reperen-6” fixed tightly to the sclera and surrounding structures forming a firm “own tissue-implant” complex. The polymeric implant “Reperen-6” can be recommended for reconstructive and regenerative surgeries to reinforce the connective tissue structures in pathological conditions of sclera and appendages of the eyes.