The site of the Media Sphera Publishers contains materials intended solely for healthcare professionals.
By closing this message, you confirm that you are a certified medical professional or a student of a medical educational institution.

Login
EN
+7 (495) 482-4118
+7 (495) 482-4329
+8 800 250-18-12
  • (toll-free number for subscriptions)
    Mon-Fri from 10 a.m. to 6 p.m.

  • © 1998-2026
+7 (495) 482-43-29
EN
All journals
Journal
Year
Year
Search result: 0

Alimbarova L.M.

Research Institute of Virology named after D.I. Ivanovsky, Ministry of Health of the Russian Federation, 16 Gamalei St., Moscow, Russian Federation, 123098

Lazarenko A.A.

Research Institute of Virology named after D.I. Ivanovsky, Ministry of Health of the Russian Federation, 16 Gamalei St., Moscow, Russian Federation, 123098

Kiselev A.V.

N.N. Semenov Institute of Chemical Physics, Russian Academy of Sciences, Moscow, Russia

Stovbun E.V.

Semenov Institute of Chemical Physics, Russian Academy of Sciences, 4 Kosygina St., Moscow, Russian Federation, 119991

Bagaeva M.I.

Kafedra akusherstva i ginekologii Rossiĭskoĭ gosudarstvennoĭ meditsinskoĭ akademii poslediplomnogo obrazovaniia, Moskva

Petryanina E.V.

N.N. Semenov Institute of Chemical Physics, Russian Academy of Sciences, Moscow, Russia

Evaluating the effectiveness of Solanum tuberosum shoots extract in experimental ocular herpes

Authors:

Alimbarova L.M., Lazarenko A.A., Kiselev A.V., Stovbun E.V., Bagaeva M.I., Petryanina E.V.

More about the authors

Journal: Russian Annals of Ophthalmology. 2015;131(3): 76‑81

DOI: 10.17116/oftalma2015131376-81

Read: 1727 times

Download PDF (RU)
Contact the author
Table of contents

EVALUATING THE EFFECTIVENESS OF SOLANUM TUBEROSUM SHOOTS EXTRACT IN EXPERIMENTAL OCULAR HERPES
EVALUATING THE EFFECTIVENESS OF SOLANUM TUBEROSUM SHOOTS EXTRACT IN EXPERIMENTAL OCULAR HERPES

To cite this article:

Alimbarova LM, Lazarenko AA, Kiselev AV, Stovbun EV, Bagaeva MI, Petryanina EV. Evaluating the effectiveness of Solanum tuberosum shoots extract in experimental ocular herpes. Russian Annals of Ophthalmology. 2015;131(3):76‑81. (In Russ.)
https://doi.org/10.17116/oftalma2015131376-81

Подписка 2026 Вестник офтальмологии (Russian Annals of Ophthalmology)
МСФ на ЯМ
Использование инфографики авторами научных работ
Close metadata
Abstract:

Ocular herpes (OH) is an infectious disease caused by the herpes simplex virus (HSV) characterized by a variable clinical presentation and often accompanied by complications that may lead to deterioration of visual functions, cataract development, or even blindness. Its treatment is arduous. The aim of this work was to evaluate the effectiveness, tolerability, and safety of Panavir eye drops in a rabbit model of OH. Material and methods. Ocular infection was induced with HSV-1 (EU strain) in grey rabbits (all males, 2.5—3.0 kg) according to the standard technique. The treatment included Panavir-GLA (Panavir-gamma-linolenic acid) and Panavir medications. Results. Panavir eye drops instilled 6 times daily for 8 days showed a pronounced therapeutic effect and prevented the development of severe corneal opacities. The most rapid and significant results were seen in rabbits with epithelial keratitis and those with short-term persistence of the virus. Generally, the effectiveness of Panavir eye drops was comparable with that of the reference drug (Oftalmoferon). Panavir instillations caused no irritation, toxic and/or allergic effects and were well tolerated by the rabbits. Conclusion. The data obtained suggest that Panavir eye drops may be included in OH treatment schemes.

Keywords:

herpes simplex virus
ocular herpes
Panavir-GLA
local therapeutic effect

Authors:

Alimbarova L.M.

Research Institute of Virology named after D.I. Ivanovsky, Ministry of Health of the Russian Federation, 16 Gamalei St., Moscow, Russian Federation, 123098

Lazarenko A.A.

Research Institute of Virology named after D.I. Ivanovsky, Ministry of Health of the Russian Federation, 16 Gamalei St., Moscow, Russian Federation, 123098

Kiselev A.V.

N.N. Semenov Institute of Chemical Physics, Russian Academy of Sciences, Moscow, Russia

Stovbun E.V.

Semenov Institute of Chemical Physics, Russian Academy of Sciences, 4 Kosygina St., Moscow, Russian Federation, 119991

Bagaeva M.I.

Kafedra akusherstva i ginekologii Rossiĭskoĭ gosudarstvennoĭ meditsinskoĭ akademii poslediplomnogo obrazovaniia, Moskva

Petryanina E.V.

N.N. Semenov Institute of Chemical Physics, Russian Academy of Sciences, Moscow, Russia

Close metadata

References:

  1. Kaufman HE. Treatment of viral diseases of the cornea and external eye. Prog Retin Eye Res. 2000;19:69-85. doi:10.1016/S1350-9462(99)00004-X
  2. Kasparov A. Ophthalmogerpes - [Ophthalmoherpes]. Moscow: Medicine; 1994. (In Russ.)
  3. Gerpesvirusnye infektsii cheloveka: rukovodstvo dlya vrachei [Нuman herpesvirus infections: a guide for physicians]. Ed. Isakov VA. Sankt-Petersburg: SpetsLit; 2013:229-239. (In Russ.)
  4. Moiseenko O, Balabina O. Effektivnost' protivovirusnogo preparata «Panavir» v kompleksnom lechenii retsidiviruyushchego oftal'mogerpesa. [Effectivity of antiviral drug «Panavir» in the complex treatment of recurrent ophthalmic]. New in Ophthalmology. 2004;4:50-51. (In Russ.)
  5. Preparat Panavir v terapii papillomavirusnoi infektsii: sbornik klinicheskikh issledovanii i nablyudenii [Panavir drug in the treatment of human papillomavirus infection: a collection of clinical studies and observations]. Moscow: Triumph; 2014. (In Russ.)
  6. Protivovirusnye svoystva preparata «Panavir» [Antiviral properties of the drug «Panavir»]. Ed. VI Sergienko. Moscow; 2005. (In Russ.)
  7. Klimovа P, Fedorov N, Kozlov A, Medzhidova M, Matushevskaya E, Sabirovа L. Vliyanie preparata panavir na techenie gerpes virusnykh infektsiy in vitro [Effect of the drug on panavir for herpes virus infections in vitro]. Bulletin dermatol and venerol. 2004;6:52-56. (In Russ.)
  8. Kaufman H, Martola E, Dohlman C. The use of 5-iodo-2-deoxyuridine (IDU) in the treatment of herpes simplex keratitis. Arch Ophthalmol. 1962;68(2):235-239. doi:10.1001/archopht.1962.00960030239015
  9. Mironov A, Bunatyan N, Vasilev А, Vеrstаkоv О, Zhuravleva М, Lepakhin V, Коrоbоv N, Меrkulоv V, Оrеkhоv S, Sаkаеvа I, Utеshеv D, Yavоrsky А. Rukovodstvo po provedeniyu doklinicheskikh issledovaniy lekarstvennykh sredstv [Guidelines for preclinical studies of drugs]. Moscow: Grief and K; 2012:527-545. (In Russ.) ISBN: 978-5-8125-1466-3
  10. Glantz C. Mediko-biologicheskaya statistika [Biomedical Statistics]. (Russ. ed): Moscow, Practice; 1999.
Contact the author
Email
Message
The publishing house "Media Sphere" does not provide treatment services, does not give recommendations on contacting medical institutions and specific specialists, on the prescription of medicines and dietary supplements.

Email Confirmation

An email was sent to test@gmail.com with a confirmation link. Follow the link from the letter to complete the registration on the site.

Email Confirmation

Submit Application

You can become an author of one of our magazines, send a request and we will consider it in during the day.

Name
Phone
E-mail
Message
Login
Registration
E-mail
Password
Forgot Password?

Log in to the site using your account in one of the services

Password recovery
E-mail
Login
Register

We use cооkies to improve the performance of the site. By staying on our site, you agree to the terms of use of cооkies. To view our Privacy and Cookie Policy, please. click here.