Peculiarities of ocular blood flow in ischemic optic neuropathy and normal tension glaucoma

Mamikonian V.R.; Galoian N.S.; Sheremet N.L.; Kazarian É.É.; Kharlap S.I.; Shmeleva-Demir O.A.; Andzhelova D.V.; Tatevosian A.A.

doi:https://doi.org/

Mamikonian V.R.

Uchrezhdenie Rossiĭskoĭ akademii meditsinskikh nauk "NII glaznykh bolezneĭ RAMN", Moskva

Galoian N.S.

FGBU "NII glaznykh bolezneĭ" RAMN, Moskva

Sheremet N.L.

FGBU "NII glaznykh bolezneĭ" RAMN

Kazarian É.É.

FGBU "NII glaznykh bolezneĭ" RAMN, Moskva

ORCID: 0000-0003-0391-4695

Kharlap S.I.

Uchrezhdenie Rossiĭskoĭ akademii meditsinskikh nauk "NII glaznykh bolezneĭ" RAMN, Moskva

Shmeleva-Demir O.A.

FGBU "NII glaznykh bolezneĭ" RAMN, Moskva

Andzhelova D.V.

FGBU "NII glaznykh bolezneĭ" RAMN

ORCID: 0000-0003-2102-2260

Tatevosian A.A.

Russian State Academy of Post-Diploma Education, Moscow

Peculiarities of ocular blood flow in ischemic optic neuropathy and normal tension glaucoma

Authors:

Mamikonian V.R., Galoian N.S., Sheremet N.L., Kazarian É.É., Kharlap S.I., Shmeleva-Demir O.A., Andzhelova D.V., Tatevosian A.A.

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Journal: Russian Annals of Ophthalmology. 2013;129(4): 3‑9

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Mamikonian VR, Galoian NS, Sheremet NL, et al. . Peculiarities of ocular blood flow in ischemic optic neuropathy and normal tension glaucoma. Russian Annals of Ophthalmology. 2013;129(4):3‑9. (In Russ.)

Подписка 2026 Вестник офтальмологии (Russian Annals of Ophthalmology)

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Abstract:

Characteristics of ocular hemodynamics in ischemic optic neuropathy (ION) outcome and normal tension glaucoma (NTG), the conditions that are difficult to be differentially diagnosed, have been investigated. The study enrolled 32 patients (40 eyes) with ION outcome, 26 patients (46 eyes) with NTG, and 20 patients (32 eyes) with no ocular pathology. Besides the standard ophthalmological examination, color Doppler imaging of ocular vessels, evaluation of ocular blood flow volume and individual normal range of intraocular pressure (flowmetry) were performed in all cases. The results showed that an excess of the actual intraocular pressure (IOP) over the individual normal range was much higher in patients with NTG than in patients with ION (39% and 14.5% correspondingly). It was also found that NTG is associated with a more significant decrease of ocular blood flow volume (30.1% in average) in comparison to ION outcome (11%). In both conditions a decrease in velocity parameters of the blood flow in main ocular vessels was registered, however, ocular hemodynamics changes appeared to be more severe in patients with glaucomatous optic neuropathy. A statistically reliable correlation between volumetric and velocity parameters of ocular blood flow has been discovered.

Keywords:

ocular blood flow volume

flowmetry

individual normal range of intraocular pressure

color Doppler imaging of ocular vessels

normal tension glaucoma

ischemic optic neuropathies

Authors:

Mamikonian V.R.

Uchrezhdenie Rossiĭskoĭ akademii meditsinskikh nauk "NII glaznykh bolezneĭ RAMN", Moskva

Galoian N.S.

FGBU "NII glaznykh bolezneĭ" RAMN, Moskva

Sheremet N.L.

FGBU "NII glaznykh bolezneĭ" RAMN

Kazarian É.É.

FGBU "NII glaznykh bolezneĭ" RAMN, Moskva

ORCID: 0000-0003-0391-4695

Kharlap S.I.

Uchrezhdenie Rossiĭskoĭ akademii meditsinskikh nauk "NII glaznykh bolezneĭ" RAMN, Moskva

Shmeleva-Demir O.A.

FGBU "NII glaznykh bolezneĭ" RAMN, Moskva

Andzhelova D.V.

FGBU "NII glaznykh bolezneĭ" RAMN

ORCID: 0000-0003-2102-2260

Tatevosian A.A.

Russian State Academy of Post-Diploma Education, Moscow

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