Peculiarities of ocular blood flow in ischemic optic neuropathy and normal tension glaucoma

Mamikonian V.R.

Uchrezhdenie Rossiĭskoĭ akademii meditsinskikh nauk "NII glaznykh bolezneĭ RAMN", Moskva

Galoian N.S.

FGBU "NII glaznykh bolezneĭ" RAMN, Moskva

Sheremet N.L.

FGBU "NII glaznykh bolezneĭ" RAMN

Kazarian É.É.

FGBU "NII glaznykh bolezneĭ" RAMN, Moskva

ORCID: 0000-0003-0391-4695

Kharlap S.I.

Uchrezhdenie Rossiĭskoĭ akademii meditsinskikh nauk "NII glaznykh bolezneĭ" RAMN, Moskva

Shmeleva-Demir O.A.

FGBU "NII glaznykh bolezneĭ" RAMN, Moskva

Andzhelova D.V.

FGBU "NII glaznykh bolezneĭ" RAMN

ORCID: 0000-0003-2102-2260

Tatevosian A.A.

Russian State Academy of Post-Diploma Education, Moscow

Peculiarities of ocular blood flow in ischemic optic neuropathy and normal tension glaucoma

Authors:

Mamikonian V.R., Galoian N.S., Sheremet N.L., Kazarian É.É., Kharlap S.I., Shmeleva-Demir O.A., Andzhelova D.V., Tatevosian A.A.

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Journal: Russian Annals of Ophthalmology. 2013;129(4): 3‑9

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To cite this article:

Mamikonian VR, Galoian NS, Sheremet NL, et al. . Peculiarities of ocular blood flow in ischemic optic neuropathy and normal tension glaucoma. Russian Annals of Ophthalmology. 2013;129(4):3‑9. (In Russ.)

Подписка 2025 (Russian Annals of Ophthalmology)

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Characteristics of ocular hemodynamics in ischemic optic neuropathy (ION) outcome and normal tension glaucoma (NTG), the conditions that are difficult to be differentially diagnosed, have been investigated. The study enrolled 32 patients (40 eyes) with ION outcome, 26 patients (46 eyes) with NTG, and 20 patients (32 eyes) with no ocular pathology. Besides the standard ophthalmological examination, color Doppler imaging of ocular vessels, evaluation of ocular blood flow volume and individual normal range of intraocular pressure (flowmetry) were performed in all cases. The results showed that an excess of the actual intraocular pressure (IOP) over the individual normal range was much higher in patients with NTG than in patients with ION (39% and 14.5% correspondingly). It was also found that NTG is associated with a more significant decrease of ocular blood flow volume (30.1% in average) in comparison to ION outcome (11%). In both conditions a decrease in velocity parameters of the blood flow in main ocular vessels was registered, however, ocular hemodynamics changes appeared to be more severe in patients with glaucomatous optic neuropathy. A statistically reliable correlation between volumetric and velocity parameters of ocular blood flow has been discovered.

Keywords:

ocular blood flow volume

flowmetry

individual normal range of intraocular pressure

color Doppler imaging of ocular vessels

normal tension glaucoma

ischemic optic neuropathies

Authors:

Mamikonian V.R.

Uchrezhdenie Rossiĭskoĭ akademii meditsinskikh nauk "NII glaznykh bolezneĭ RAMN", Moskva

Galoian N.S.

FGBU "NII glaznykh bolezneĭ" RAMN, Moskva

Sheremet N.L.

FGBU "NII glaznykh bolezneĭ" RAMN

Kazarian É.É.

FGBU "NII glaznykh bolezneĭ" RAMN, Moskva

ORCID: 0000-0003-0391-4695

Kharlap S.I.

Uchrezhdenie Rossiĭskoĭ akademii meditsinskikh nauk "NII glaznykh bolezneĭ" RAMN, Moskva

Shmeleva-Demir O.A.

FGBU "NII glaznykh bolezneĭ" RAMN, Moskva

Andzhelova D.V.

FGBU "NII glaznykh bolezneĭ" RAMN

ORCID: 0000-0003-2102-2260

Tatevosian A.A.

Russian State Academy of Post-Diploma Education, Moscow

List of references:

Avetisov S.E., Mamikonyan V.R., Kazaryan E.E., Shmeleva-Demir O.A., Mazurova Yu.V., Ryzhkova E.G., Galoyan N.S., Tatevosyan A.A. Novyi skriningovyi metod opredeleniya tolerantnogo vnutriglaznogo davleniya. Vestn oftal'mol 2009; 125: 5: 3-7.
Avetisov S.E., Mamikonyan V.R., Kazaryan E.E., Shmeleva-Demir O.A., Galoyan N.S., Mazurova Yu.V., Tatevosyan A.A., Ryzhkova E.G. Rezul'taty klinicheskoi otsenki novogo skriningovogo metoda opredeleniya individual'noi normy vnutriglaznogo davleniya. Vestn oftal'mol 2010; 126: 2: 5-7.
Volkov V.V. O razlichiyakh v patogeneze, klinicheskom techenii, lechenii i profilaktike glaukomnoi i ishemicheskoi opticheskikh neiropatii. Vestn oftal'mol 2010; 126: 1: 3-14.
Kazaryan E.E. Sovershenstvovanie i ob''ektivizatsiya kriteriev diagnostiki i monitoringa pervichnoi otkrytougol'noi glaukomy: Avtoref. dis. ... d-ra med. nauk. 2011.
Kiseleva T.N. Tsvetovoe dopplerovskoe kartirovanie v oftal'mologii. Vestn oftal'mol 2001: 6: 51-53.
Kozlova I.V. Sostoyanie krovoobrashcheniya v zritel'nom nerve pri glaukomnoi opticheskoi neiropatii po dannym prostranstvennogo kombinirovannogo ul'trazvukovogo issledovaniya: Avtoref. dis. ... kand. med. nauk. 2010.
Kotlyar K.E. Metody issledovaniya gemodinamiki glaza. V kn.: Klinicheskaya fiziologiya zreniya. 3-e izd. M 2006; 639-740.
Kurysheva N.I. Glaukomnaya opticheskaya neiropatiya. 2006; 14-25.
Mamikonyan V.R., Kazaryan E.E., Shmeleva-Demir O.A., Galoyan N.S., Mazurova Yu.V., Tatevosyan A.A. Novyi podkhod k opredeleniyu individual'noi normy vnutriglaznogo davleniya. IX s''ezd oftal'mologov Rossii. M 2010; 164.
Smirnova T.V. Perednyaya ishemicheskaya neiropatiya, assotsiirovannaya s antifosfolipidnym sindromom. Vestn oftal'mol 2006; 122: 6: 46-47.
Kharlap S.I. Biometricheskie sootnosheniya i gemodinamicheskie kharakteristiki sosudistoi sistemy glaza i orbity v norme i pri patologii po rezul'tatam sovremennykh metodov ul'trazvukovogo klinicheskogo prostranstvennogo analiza: Dis. ... d-ra med. nauk. M 2003.
Sheremet N.L. Druzy diska zritel'nogo nerva. Soobshchenie 2. Rol' v etiopatogeneze opticheskoi neiropatii. Vestn oftal'mol 2010; 126: 2: 11-15.
Akcar N., Yildirim N., Adapinar B., Kaya T., Ozkan I.R. Duplex sonography of retro-orbital and carotid arteries in patients with normal-tension glaucoma. J Clin Ultrasound 2005; 33: 6: 270-276.
Bjärnhall G., Tomic L., Mishima H.K., Tsukamoto H., Alm A. Retinal mean transit time in patients with primary open-angle glaucoma and normal-tension glaucoma. Acta Ophthalmol Scand 2007; 85: 1: 67-72.
Carenini A.B., Sibour G., Boles Carenini B. Differences in the long-term effect of timolol and betaxolol on the pulsatile ocular flow. Surv Ophthalmol 1994; 38 (Suppl): S118-124.
Deokule S., Vizzeri G., Boehm A.G., Bowd C., Medeiros F.A., Weinreb R.N. Correlation among choroidal, parapapillary, and retrobulbar vascular parameters in glaucoma. Am J Ophthalmol 2009; 147: 4: 736-743. e2. Epub 2009 Feb 1.
Cioffi G.A., Alm A. Measurement of ocular blood flow. J Glaucoma 2001; 10: 5 (Suppl 1): 62-64.
Gronkowska J., Karczewicz D. Papillary blood flow and morphological parameters of the optic nerve head in patients with normal tension glaucoma, primary open angle glaucoma and in healthy volunteers. Klin Oczna 2004; 106 (1-2; Suppl): 217-221.
Hayreh S.S. The blood supply of the optic nerve head and the evaluation of it - myth and reality. Prog Retin Eye Res 2001; 20: 5: 563-593.
Hayreh S.S. Blood flow in the optic nerve head and factors that may influence it. Prog Retin Eye Res 2001; 20: 5: 595-624.
Kawabata K., Kimura T., Fujiki K., Murakami A. Ocular pulse amplitude in patients with open-angle glaucoma, normal-tension glaucoma, and ocular hypertensionby dynamic observing tonometry. Nippon Ganka Gakkai Zasshi 2007; 111: 12: 946-952.
Lam A.K., Chan S.T., Chan B., Chan H. The effect of axial length on ocular blood flow assessment in anisometropes. Ophthalmic Physiol Opt 2003; 23: 4: 315-320.
Obuchowska I., Ustymowicz A., Mariak Z. Application of Color Doppler ultrasonography in the evaluation of the blood flow in the ocular vessels in patients with anterior ischemic optic neuropathy - the preliminary report. Klin Oczna 2006; 108: 7-9: 290-293.
Plange N., Remky A., Arend O. Colour Doppler imaging and fluorescein filling defects of the optic disc in normal tension glaucoma. Br J Ophthalmol 2003; 87: 6: 731-736.
Plange N., Kaup M., Huber K., Remky A., Arend O. Fluorescein filling defects of the optic nerve head in normal tension glaucoma, primary open-angle glaucoma, ocular hypertension and healthy controls. Ophthalmic Physiol Opt 2006; 26: 1: 26-32.
Plange N., Kaup M., Remky A., Arend K.O. Prolonged retinal arteriovenous passage time is correlated to ocular perfusion pressure in normal tension glaucoma. Graefes Arch Clin Exp Ophthalmol 2008; 246: 8: 1147-1152. Epub 2008 Apr 2.
Sato E.A., Ohtake Y., Shinoda K., Mashima Y., Kimura I. Decreased blood flow at neuroretinal rim of optic nerve head corresponds with visual field deficit in eyes with normal tension glaucoma. Graefes Arch Clin Exp Ophthalmol 2006; 244: 7: 795-801. Epub 2005 Nov 29.
Schwenn O., Troost R., Vogel A., Grus F., Beck S., Pfeiffer N. Ocular pulse amplitude in patients with open angle glaucoma, normal tension glaucoma, and ocular hypertension. Br J Ophthalmol 2002; 86: 9: 981-984.
Takahashi S., Tomita G., Sugiyama K., Sato Y., Kitazawa Y. Blood flow in retinal vessels of normal-tension glaucoma with or without a history of optic disc hemorrhages. Ganka Gakkai Zasshi 2001; 105: 3: 177-182.
Weinreb R.N., Harris A. Ocular blood flow in glaucoma. Consensus series 6. 2009.
Załuczkowska-Marcela K., Rusek P., Dudziński A., Filipecka I. Assessment of the retinal blood flow by DRG retina Doppler in primary open angle glaucoma and normal tension glaucoma. Klin Oczna 2000; 102: 2: 115-118.
Zeitz O., Matthiessen E.T., Reuss J., Wiermann A., Wagenfeld L., Galambos P., Richard G., Klemm M. Effects of glaucoma drugs on ocular hemodynamics in normal tension glaucoma: a randomized trial comparing bimatoprost and latanoprost with dorzolamide. BMC Ophthalmol 2005; 5: 6.
Zhang M.Z., Fu Z.F., Liu X.R., Zheng C. A comparison study of pulsitile ocular blood flow in normal eyes and primary open angle glaucoma. Zhonghua Yan Ke Za Zhi 2004; 40: 4: 250-253.
Zhong Y., Min Y., Jiang Y., Cheng Y., Qin J., Shen X. Color Doppler imaging and pattern visual evoked potential in normal tension glaucoma and hypertension glaucoma. Doc Ophthalmol 2009; 119: 3: 171-180. Epub 2009 Sep 12.

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