Evaluation of the efficacy of pregabalin in the therapy of chronic pain in patients with knee osteoarthritis

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Filatova E.S.

FGBU "Nauchno-issledovatel'skiĭ institut revmatologii im. V.A. Nasonovoĭ" RAMN, Moskva

Turovskaia E.F.

FGBU "Nauchno-issledovatel'skiĭ institut revmatologii im. V.A. Nasonovoĭ" RAMN, Moskva;
FGBOU "Pervyĭ Moskovskiĭ gosudarstvennyĭ meditsinskiĭ universitet im. I.M. Sechenova", Moskva

Alekseeva L.I.

Research Institute of Rheumatology n.a. V.A. Nasonova, Moscow, Russia

Evaluation of the efficacy of pregabalin in the therapy of chronic pain in patients with knee osteoarthritis

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Filatova E.S., Turovskaia E.F., Alekseeva L.I.

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Journal: Therapeutic Archive. 2017;89(12): 81‑85

DOI: 10.17116/terarkh2017891281-85

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To cite this article:

Filatova ES, Turovskaia EF, Alekseeva LI. Evaluation of the efficacy of pregabalin in the therapy of chronic pain in patients with knee osteoarthritis. Therapeutic Archive. 2017;89(12):81‑85. (In Russ.)
https://doi.org/10.17116/terarkh2017891281-85

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Abstract:

Aim. To evaluate the efficacy of pregabalin in the therapy of chronic pain in patients with knee osteoarthritis (KOA). Subjects and methods. The study enrolled 60 patients with KOA and neuropathic pain component (NPC) (Douleur Neuropathique en 4 questions (DN4) questionnaire scores, >4) who were randomized into two groups to receive aceclofenac or aceclofenac + pregabalin for 5 weeks. All the patients underwent clinical and neurological examinations, assessment of the functional WOMAC index, pain intensity at rest and during movement, and diagnosis of neuropathic pain (NP) (DN4 and Pain DETECT questionnaires). Results. Both groups were observed to have positive changes in the studied parameters; however, combination therapy using an anticonvulsant drug (pregabalin) showed a more pronounced positive effect against not only NPC, but also the functional activity (WOMAC) and severity of pain (visual analogue scale). Conclusion. Combination therapy using pregabalin in KOA patients having the signs of NP is more effective than monotherapy with nonsteroidal anti-inflammatory drugs (aceclofenac).

Keywords:

knee osteoarthritis

neuropathic pain component

pregabalin

aceclofenac

pregabalin-Richter

Airtal

Authors:

Filatova E.S.

FGBU "Nauchno-issledovatel'skiĭ institut revmatologii im. V.A. Nasonovoĭ" RAMN, Moskva

Turovskaia E.F.

FGBU "Nauchno-issledovatel'skiĭ institut revmatologii im. V.A. Nasonovoĭ" RAMN, Moskva;
FGBOU "Pervyĭ Moskovskiĭ gosudarstvennyĭ meditsinskiĭ universitet im. I.M. Sechenova", Moskva

Alekseeva L.I.

Research Institute of Rheumatology n.a. V.A. Nasonova, Moscow, Russia

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References:

Rossiiskie rekomendacii. Revmatologia. Pod Redakciei akademika RAN Nasonova EL. M.:GEOTAR-Media.-2017:456. (In Russ.)
Doherty M. Pain in osteoarthritis. In: Giamberardino MA, editor. Pain; 2002: an updated review: refresher course syllabus. Seattle: IASP Press; 2002:51-57.
Breivik H, Collett B, Ventafridda V, Cohen R, Gallacher D. Survey of chronic pain in Europe: prevalence, impact on daily life, and treatment. European Journal of Pain. 2006;10:287-333. https://doi.org/10.1016/j.ejpain.2005.06.009
Nidhi Sofat, Vivian Ejindu, Patrick Kiely. What makes osteoarthritis painful? The evidence for Local and Central pain processing. Rheumatology. 2011;50(12):2157-2165. https://doi.org/10.1093/rheumatology/ker283
Wylde V, Hewlett S, Learmonth ID, Dieppe P. Persistant pain after joint replacement: Prevalence, sensory qualities, and postoperative determinants. Pain. 2011;152:566-572. https://doi.org/10.1016/j.pain.2010.11.023
Туровская Е.Ф., Алексеева Л.И., Филатова Е.Г. Механизмы хронической боли при остеоартрозе коленного сустава. Научно-практическая ревматология. 2014;52(5):526-529. https://doi.org/10.14412/1995-4484-2014-526-529
Hochman JR, French MR, Bermingham SL. The nerve of Osteoarthritis Pain. Arthritis care and research. 2010;62(7):1019-1023. https://doi.org/10.1002/acr.20142
Bryan J Moreton, Victoria Tew, Roshan das Nair, Maggie Wheeler, David A Walsh, Nadina B Lincoln. Pain phenotype in people with knee osteoarthritis; classification and measurement properties of painDETECT and S-LANSS in a cross-sectional study. Arthritis Care & Research. 2014. American College of Rheumatology. P1-36. https://doi.org/10.1002/acr.22431
Hochman JR, Davis AM, Elkayam z J, Gaiese L, Hawker GA. Neuropathic pain symptoms on the modified painDETECT correlate with signs of central sensitization in knee osteoarthritis Osteoarthritis and Cartilage. 2013;21:1236-1242. https://doi.org/10.1016/j.joca.2013.06.023
Baliki MN, Geha PY, Jabakhanji R, Harden N, Schnitzer TJ, Apkarian AV. A preliminary fMRI study of analgesic treatment in chronic back pain and knee osteoarthritis. Mol Pain 2008;4:47. https://doi.org/10.1186/1744-8069-4-47
Maihofner C, Handwerker HO, Birklein F. Functional Iamging of allodynia in complex regional pain syndrome. Neurology 2006; 66: 711-717. https://doi.org/10.1212/01.wnl.0000200961.49114.39
Apkarian AV, Bushnell MC, Treede RD, Zubieta JK. Human brain mechanisms in pain perception and regulation in health and disease. Eur J Pain 2005;9:463-484. https://doi.org/10.1016/j.ejpain.2004.11.001
Nidhi S, Vivian E. Patrick K. What makes osteoarthritis painful? The evidence for local and central pain processing. Rheumatology 2011;50:2157-2165. https://doi.org/10.1093/rheumatology/ker283
Chappell AS, Dessaiah D, Liu-Seifert H, Zhang Sh, Skljarevski V, Belenkov Y, Brown J. A double-blind, randomized, placebo-controlled study of the efficacy and safety of duloxetine for the treatment of chronic pain due to osteoarthritis of the knee. Pain Pract 2011;11:33-41. https://doi.org/10.1111/j.1533-2500.2010.00401.x
Abou-Raya S, Abou-Raya A, Helmii M. Duloxetine for the management of pain in older adults with knee osteoarthritis: randomised placebo-controlled trial. Age Ageing. 2012;41(5):646-652. https://doi.org/10.1093/ageing/afs072
Filatova ES, Turovskaya EF, Alekseeva LI, Erdes ShF, Nasonov EL. Neurogenic mechanisms of chronic joint pain. Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova. 2013;113(12): 45-49. (In Russ.)
Registr lekarstvennix sredstv Rossii. RLS-Media 2009, p.464. (In Russ.)
Ivanavicius SP, Ball AD, Heapy CG, Westwood FR, Murray F, Read SJ. Structural pathology in a rodent model of osteoarthritis is associated with neuropathic pain: increased expression of ATF-3 and pharmacological characterisation. Pain 2007;128:272-282.

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