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Kozhevnikov M.L.

Virion Research-and-Production Association, Branch, Microgen Research-and-Production Association, Ministry of Health of Russia, Tomsk, Russia

Shipulin V.M.

Cardiology Research Institute, Tomsk National Research Medical Center, Russian Academy of Sciences, Tomsk, Russia;
Siberian State Medical University, Tomsk, Russia

Sukhodolo I.V.

Siberian State Medical University, Ministry of Health of Russia, Tomsk, Russia

The virus-immune hypothesis for cardiac dilatation

Authors:

Kozhevnikov M.L., Shipulin V.M., Sukhodolo I.V.

More about the authors

Journal: Therapeutic Archive. 2017;89(11): 79‑83

DOI: 10.17116/terarkh2017891179-83

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Table of contents

THE VIRUS-IMMUNE HYPOTHESIS FOR CARDIAC DILATATION
THE VIRUS-IMMUNE HYPOTHESIS FOR CARDIAC DILATATION

To cite this article:

Kozhevnikov ML, Shipulin VM, Sukhodolo IV. The virus-immune hypothesis for cardiac dilatation. Therapeutic Archive. 2017;89(11):79‑83. (In Russ.)
https://doi.org/10.17116/terarkh2017891179-83

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Abstract:

The paper gives an update on the pathogenetic role of viral infection and immune mechanisms in the development of cardiac dilatation at the cellular, ultrastructural, and molecular levels. Particular attention is given to the discussion of the possible role of herpesvirus infection in the mechanisms of cardiomyocyte damage with the direct or indirect impact of viral infection through immunoinflammatory responses. Data on the protective and damaging action of a number of cytokines in the immunopathogenesis of viral myocarditis are considered.

Keywords:

cardiac dilatation
cardiomyocyte
herpesvirus
myocarditis

Authors:

Kozhevnikov M.L.

Virion Research-and-Production Association, Branch, Microgen Research-and-Production Association, Ministry of Health of Russia, Tomsk, Russia

Shipulin V.M.

Cardiology Research Institute, Tomsk National Research Medical Center, Russian Academy of Sciences, Tomsk, Russia;
Siberian State Medical University, Tomsk, Russia

Sukhodolo I.V.

Siberian State Medical University, Ministry of Health of Russia, Tomsk, Russia

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