Therapy for primary mediastinal large B-cell lymphoma in accordance with the R-DA-EPOCH-21 program: The first results

Mangasarova Ia.K.; Magomedova A.U.; Nesterova E.S.; Volodicheva E.M.; Vorob’ev V.I.; Kravchenko S.K.

doi:https://doi.org/10.17116/terarkh201688737-42

Mangasarova Ia.K.

Gematologicheskiĭ nauchnyĭ tsentr Minzdrava Rossii

Magomedova A.U.

Federal Research and Clinical Center of Sports Medicine, Federal Biomedical Agency of the Russia, Moscow, Russia

Nesterova E.S.

Gematologicheskiĭ nauchnyĭ tsentr Minzdrava Rossii

Volodicheva E.M.

Tula Regional Clinical Hospital

Vorob’ev V.I.

S.P. Botkin State Clinical Hospital, Moscow, Russia

Kravchenko S.K.

Gematologicheskiĭ nauchnyĭ tsentr Minzdrava Rossii

Therapy for primary mediastinal large B-cell lymphoma in accordance with the R-DA-EPOCH-21 program: The first results

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Mangasarova Ia.K., Magomedova A.U., Nesterova E.S., Volodicheva E.M., Vorob’ev V.I., Kravchenko S.K.

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Journal: Therapeutic Archive. 2016;88(7): 37‑42

DOI: 10.17116/terarkh201688737-42

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Mangasarova IaK, Magomedova AU, Nesterova ES, Volodicheva EM, Vorob’ev VI, Kravchenko SK. Therapy for primary mediastinal large B-cell lymphoma in accordance with the R-DA-EPOCH-21 program: The first results. Therapeutic Archive. 2016;88(7):37‑42. (In Russ.)
https://doi.org/10.17116/terarkh201688737-42

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Refractory/relapsed primary mediastinal large B-cell lymphoma: a changing paradigm for drug therapy. P.A. Herzen Journal of Oncology. 2025;(4):107-116

Abstract:

Aim. To evaluate the efficiency of the R-DA-EPOCH-21 + R-DHAP protocol and autologous hematopoietic stem cell transplantation (a BEAM conditioning mode) in first-line therapy for primary mediastinal large B-cell lymphoma (PMBCL). Subjects and methods. In 2013 to 2016, the investigation enrolled 57 patients with newly diagnosed PMBCL (according to the 2008 WHO criteria). The results were analyzed in 40 patients who had completed their treatment. Results. All the 40 patients (14 men and 26 women) (median age, 27 years (19 to 67 years)) received 6 cycles of polychemotherapy (PCT) in accordance with the R-DA-EPOCH-21 regimen. After induction PCT cycles, 32/40 (80%) patients achieved complete remission. Partial remission was stated in 8/40 (20%) patients who had further 2 cycles of chemotherapy using the R-DHAP program and autologous hematopoietic stem cell transplantation (a BEAM conditioning mode). Two-year overall and relapse-free survival rates were 100% and 96%, respectively; the median follow-up was 17 months. Conclusion. The R-DA-EPOCH regimen allows complete remission in 80% of the cases and two-year survival in 100%. If there are unfavorable factors at onset and in partial remission, it is appropriate to intensify treatment at early stages, by using high-dose chemotherapy and autologous hematopoietic stem transplantation.

Keywords:

primary mediastinal large B-cell lymphoma

R-DA-EPOCH-21

R-DHAP

autologous hematopoietic stem cell transplantation

Authors:

Mangasarova Ia.K.

Gematologicheskiĭ nauchnyĭ tsentr Minzdrava Rossii

Magomedova A.U.

Federal Research and Clinical Center of Sports Medicine, Federal Biomedical Agency of the Russia, Moscow, Russia

Nesterova E.S.

Gematologicheskiĭ nauchnyĭ tsentr Minzdrava Rossii

Volodicheva E.M.

Tula Regional Clinical Hospital

Vorob’ev V.I.

S.P. Botkin State Clinical Hospital, Moscow, Russia

Kravchenko S.K.

Gematologicheskiĭ nauchnyĭ tsentr Minzdrava Rossii

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