Celiac disease detection rate in gastroenterological patients

Bykova S.V.

Moskovskiĭ klinicheskiĭ nauchno-prakticheskiĭ tsentr. TsNII gastronterologii Departamenta zdravookhraneniia Moskvy

Sabel'nikova E.A.

Moskovskiĭ klinicheskiĭ nauchno-prakticheskiĭ tsentr

Gudkova R.B.

GBUZ "Tsentral'nyĭ nauchno-issledovatel'skiĭ institut gastroénterologii" Departamenta zdravookhraneniia Moskvy

Drozdov V.N.

TsNII gastroénterologii Departamenta zdravookhraneniia Moskvy

Shcherbakov P.L.

GBUZ "Moskovskiĭ klinicheskiĭ nauchno-prakticheskiĭ tsentr" Departamenta zdravookhraneniia Moskvy

Kirova M.V.

Moscow Clinical Research and Practical Center, Moscow Healthcare Department, Moscow, Russia

Khomeriki S.G.

Moscow Clinical Research and Practical Centre, Moscow Health Department, Central Research Institute of Gastroenterology, Moscow

Varvanina G.G.

Moskovskij klinicheskij nauchno-prakticheskij tsentr, 111123 Moskva, shosse Entuziastov, 86

Belyaeva A.A.

Moscow Clinical Research and Practical Center, Moscow Healthcare Department, Moscow, Russia

Parfenov A.I.

GBUZ "Moskovskiĭ klinicheskiĭ nauchno-prakticheskiĭ tsentr" Departamenta zdravookhraneniia Moskvy

Celiac disease detection rate in gastroenterological patients

Authors:

Bykova S.V., Sabel'nikova E.A., Gudkova R.B., Drozdov V.N., Shcherbakov P.L., Kirova M.V., Khomeriki S.G., Varvanina G.G., Belyaeva A.A., Parfenov A.I.

More about the authors

Journal: Therapeutic Archive. 2016;88(2): 39‑43

DOI: 10.17116/terarkh201688239-43

Downloaded: 539

Download PDF (RU)

Contact the author

Table of contents

To cite this article:

Bykova SV, Sabel'nikova EA, Gudkova RB, et al. . Celiac disease detection rate in gastroenterological patients. Therapeutic Archive. 2016;88(2):39‑43. (In Russ.)
https://doi.org/10.17116/terarkh201688239-43

Close metadata

Aim. To determine celiac disease detection rate in patients with digestive disease. Subjects and methods. A total of 318 gastroenterological patients admitted to be treated at the Central Research Institute of Gastroenterology in September to October 2012 were examined. The patients’ age was 18 to 74 years (mean 51.5±16.4 years). Immunoglobulin A (IgA) and immunoglobulin G (IgG) anti-gliadin antibodies (AGA), IgA anti-tissue transglutaminase (anti-tTG) antibodies and IgG anti-tTG antibodies were determined. When the antibodies were elevated, esophagogastroduodenoscopy with duodenal biopsy was performed. Results. Forty-one of the 318 patients were found to have higher AGA (12.9%); out of them IgA AGA were in 17 (5.35%) patients and IgG AGA were also in 17 (5.35%). Elevated levels of both antibodies (IgA AGA and IgG AGA) were seen in 7 (2.2%) patients. Overall, the detection rate of increased AGA levels was 12.9%. The antibodies were more commonly higher in patients with liver diseases (21.8%) and in those with inflammatory bowel diseases (21.6%). Both IgA anti-tTG, IgG anti-tTG and IgA AGA, IgG AGA were detected in 6 (1.9%) of the 318 patients. The diagnosis of celiac disease was verified by duodenal histological examination in 3 (0.94%) of the 318 patients. Conclusion. The celiac disease detection rate in gastroenterological patients was 0.94%.

Keywords:

celiac disease

anti-tissue transglutaminase antibodies

anti-gliadin antibodies

duodenoscopy

Authors:

Bykova S.V.

Moskovskiĭ klinicheskiĭ nauchno-prakticheskiĭ tsentr. TsNII gastronterologii Departamenta zdravookhraneniia Moskvy

Sabel'nikova E.A.

Moskovskiĭ klinicheskiĭ nauchno-prakticheskiĭ tsentr

Gudkova R.B.

GBUZ "Tsentral'nyĭ nauchno-issledovatel'skiĭ institut gastroénterologii" Departamenta zdravookhraneniia Moskvy

Drozdov V.N.

TsNII gastroénterologii Departamenta zdravookhraneniia Moskvy

Shcherbakov P.L.

GBUZ "Moskovskiĭ klinicheskiĭ nauchno-prakticheskiĭ tsentr" Departamenta zdravookhraneniia Moskvy

Kirova M.V.

Moscow Clinical Research and Practical Center, Moscow Healthcare Department, Moscow, Russia

Khomeriki S.G.

Moscow Clinical Research and Practical Centre, Moscow Health Department, Central Research Institute of Gastroenterology, Moscow

Varvanina G.G.

Moskovskij klinicheskij nauchno-prakticheskij tsentr, 111123 Moskva, shosse Entuziastov, 86

Belyaeva A.A.

Moscow Clinical Research and Practical Center, Moscow Healthcare Department, Moscow, Russia

Parfenov A.I.

GBUZ "Moskovskiĭ klinicheskiĭ nauchno-prakticheskiĭ tsentr" Departamenta zdravookhraneniia Moskvy

List of references:

Parfenov A.I. Tseliakiya. Evolyutsiya predstavlenii o rasprostranennosti, klinicheskikh proyavleniyakh i znachimosti etiotropnoi terapii. M.: Anakharsis; 2007.
Wengrower D, Doron D, Goldin WE, Granot E. Should stored serum of patients previously tested for celiac disease serology be retested for transglutaminase antibodies? J Clin Gastroenterol. 2006;40:806-808.
Leffler DA, Schuppan D. Update in serologic testing inceliac disease. Am J Gastroenterol. 2010;105:2520-2524.
Carroccio A, Vitale G, DiPrima L, Chifari N, Napoli S, La Russa C et al. Comparison of anti-transglutaminase ELISAs and an anti-endomysial antibody assay in the diagnosis of celiac disease: A prospective study. Clin Chem. 2002;48:1546-1550.
Gillett HR, Freeman HJ. Comparison of IgA endomysium antibody and IgA tissue transglutaminase antibody in celiac disease. Can J Gastroenterol. 2000;14:668-671.
Korponay-Szabó IR, Halttunen T, Szalai Z, Laurila K, Király R, Kovács JB, Fésüs L, Mäki M. In vivo targeting of intestinal and extraintestinal transglutaminase 2 by coeliac autoantibodies. Gut. 2004;53:641-648. doi:10.1136/gut.2003.024836.
Ankelo M, Kleimola V, Simell S. Antibody responses to deamidated gliadin peptide show high specificity and parallel antibodies to tissue transglutaminase in developing celiac disease. Clin Exp Immunol. 2007;150(2):285-293.
Astrid Collats Schyum, Juri Rumessen. Serological testing for celiac disease in adults. United Eur Gastroenter J. Available at: http://ueg.sagepub.com/content/1/5/319.full
Marsh M. Gluten, major histocompatability complex and small intestine. A molecular and immunobiological approach to the spectrum of gluten sensitivity. Gastroenterology. 1992;102:330-354.
Sabel'nikova E.A., Parfenov A.I., Krums L.M., Gudkova R.B. Tseliakiya kak prichina zhelezodefitsitnoi anemii. Terapevticheskii arkhiv. 2006;2:45-48.
Bykova S.V., Parfenov A.I., Tetruashvili N.K., Sabel'nikova E.A., Gudkova R.B., Krums L.M., Vorob'eva N.N., Repina E.A., Vityazeva I.N., Petukhova G.S. Rasprostranennost' glyutenchuvstvitel'noi tseliakii u zhenshchin s narusheniem reproduktivnoi funktsii. Terapevticheskii arkhiv. 2012;83(2): 31-35.
Shor DB, Orbach H, Boaz M, Alman A, Anaya JM and all. Gastrointestinal-associated autoantibodies in different autoimmume disease. Am J Clin Exp Immunol. 2012;1(1):49-55.
Tursi A, Giorgetti GM, Brandimarte G, Elisei W. Crohn´s disease and celiac disease: association or epiphenomenon? Eur Rep Med Pharmacol Sci. 2006;10(3):127-130.
Tavakkoli H, Haghdani S, Adilipour H, Daghaghzadeh H, Minakari M, Adibi P, Ahmadi K, Emami M H. Serologic celiac disease in patients with inflammatory bowel disease. J Res Med Sci. 2012;17(2):154-158.
Leeds JS, Höroldt BS, Sidhu R, Hopper AD, Robinson K, Toulson B, Dixon L, Lobo AJ, McAlindon ME, Hurlstone DP, Sanders DS. Is there an association between coeliac disease and inflammatory bowel diseases? A study of relative prevalence in comparison with population controls. Scand J Gastroenterol. 2007;42(10):1214-1220.
Oxford EC, Nguyen DD, Sauk J, Korzenik JR, Yajnik V, Friedman S, Ananthakrishnan AN. Impact of coexistent celiac disease on phenotype and natural history of inflammatory bowel diseases. Am J Gastroenterol. 2013;108(7):1123-1129. doi:10.1038/ajg.2013.20.
Shayesteh AA, Hajiani E, Hashemi SJ, Masjedizadeh A, Latifi SM, Shayesteh M. Prevalence of celiac disease in Iranian patients with irritable bowel syndrome: A cross-sectional study. J Dig Dis. 2014;15(1):12-17. doi:10.1111/1751-2980.12102.
Parfenov A.I., Gudkova R.B., Krums L.M., Sabel'nikova E.A. Chastota tseliakii u bol'nykh khronicheskoi diareei. Terapevticheskii arkhiv. 2003;9:55-60.
Drastich P, Honsová E, Lodererová A, Jarešová M, Pekáriková A, Hoffmanová I, Tučková L, Tlaskalová-Hogenová H, Špičák J, Sánchez D. Celiac disease markers in patients with liver diseases: A single center large scale screening study. World J Gastroenterol. 2012;18(43):6255-6262.
Mirzaagha F, Azali SH, Islami F, Zamani F, Khalilipour E, Khatibian M, Malekzadeh R. Coeliac disease in autoimmune liver disease: a cross-sectional study and a systematic review. Dig Liver Dis. 2010;42:620-623.
Volta U. Liver dysfunction in celiac disease. Minerva Med. 2008;99:619-629.
Mounajjed T, Oxentenko A, Shmidt E, Smyrk T. The liver in celiac disease: clinical manifestations, histologic features, and response to gluten-free diet in 30 patients. Am J Clin Pathol. 2011;136:128-137.
Casella G, Antonelli E, Di Bella C, Vilanacci V, Fanini L, Baldini V, Bassotti G. Prevalence and causes of abnormal liver function in patients with celiac disease. Liver Int. 2013;33(7):1128-1131.
Sabel'nikova E.A., Parfenov A.I., Tsaregorodtseva T.M., Tkachev V.D., Toporkov A.S., Chikunova B.Z., Shepeleva S.D. Izmeneniya pecheni pri glyutenovoi enteropatii. Terapevticheskiiarkhiv. 2003;2:31-35.

Close metadata