Multiple myeloma predominantly involving the spleen

Ryzhko V.V.

FGBU "Gematologicheskiĭ nauchnyĭ tsentr" Ministerstva zdravookhraneniia Rossiĭskoĭ Federatsii, Moskva

Klodzinskiĭ A.A.

Respublikanskiĭ nauchnyĭ tsentr neotlozhnoĭ meditsinskoĭ pomoshchi, Kazakhstan

Grachev A.E.

Gematologicheskiĭ nauchnyĭ tsentr Minzdrava Rossii, Moskva

Varlamova E.Iu.

FGBU "Gematologicheskiĭ nauchnyĭ tsentr" Ministerstva zdravookhraneniia Rossiĭskoĭ Federatsii, Moskva

Sataeva M.S.

Respublikanskiĭ nauchnyĭ tsentr neotlozhnoĭ meditsinskoĭ pomoshchi, Kazakhstan

Nakastoev I.M.

Gematologicheskiĭ nauchnyĭ tsentr Minzdrava Rossii, Moskva

Multiple myeloma predominantly involving the spleen

Authors:

Ryzhko V.V., Klodzinskiĭ A.A., Grachev A.E., Varlamova E.Iu., Sataeva M.S., Nakastoev I.M.

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Journal: Therapeutic Archive. 2013;85(7): 84‑86

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Ryzhko VV, Klodzinskiĭ AA, Grachev AE, Varlamova EIu, Sataeva MS, Nakastoev IM. Multiple myeloma predominantly involving the spleen. Therapeutic Archive. 2013;85(7):84‑86. (In Russ.)

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Extramedullary disease is an uncommon manifestation in multiple myeloma (MM) and can be observed at onset or develop at disease progression or relapse. Splenic involvement is very rare. The paper describes a 52-year-old female patient with MM who in 1990 was diagnosed with monoclonal gammopathy of undetermined significance with IgGκ secretion and a considerably enlarged spleen. Specific therapy with bortezomib and dexamethasone was initiated in 2006 and proved to be inefficient. After splenectomy there was a 50% reduction in IgGκ concentration. Splenic histological examination revealed monoclonal infiltration by the pleomorphic plasma cells expressing a kappa light chain.

Keywords:

multiple myeloma

spleen

bortezomib

thalidomide

Authors:

Ryzhko V.V.

FGBU "Gematologicheskiĭ nauchnyĭ tsentr" Ministerstva zdravookhraneniia Rossiĭskoĭ Federatsii, Moskva

Klodzinskiĭ A.A.

Respublikanskiĭ nauchnyĭ tsentr neotlozhnoĭ meditsinskoĭ pomoshchi, Kazakhstan

Grachev A.E.

Gematologicheskiĭ nauchnyĭ tsentr Minzdrava Rossii, Moskva

Varlamova E.Iu.

FGBU "Gematologicheskiĭ nauchnyĭ tsentr" Ministerstva zdravookhraneniia Rossiĭskoĭ Federatsii, Moskva

Sataeva M.S.

Respublikanskiĭ nauchnyĭ tsentr neotlozhnoĭ meditsinskoĭ pomoshchi, Kazakhstan

Nakastoev I.M.

Gematologicheskiĭ nauchnyĭ tsentr Minzdrava Rossii, Moskva

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