Dermal mast cells density examination as an aspect of mechanical injuries vitality diagnostics

Kupriyanov D.D.; Fedulova M.V.

doi:https://doi.org/10.17116/sudmed20246706125

Kupriyanov D.D.

Russian Center of Forensic Medical Expertise

ORCID: 0000-0003-2730-1797

Fedulova M.V.

Russian Center of Forensic Medical Expertise

ORCID: 0000-0002-8787-2228

Dermal mast cells density examination as an aspect of mechanical injuries vitality diagnostics

Authors:

Kupriyanov D.D., Fedulova M.V.

More about the authors

Journal: Forensic Medical Expertise. 2024;67(6): 25‑29

DOI: 10.17116/sudmed20246706125

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To cite this article:

Kupriyanov DD, Fedulova MV. Dermal mast cells density examination as an aspect of mechanical injuries vitality diagnostics. Forensic Medical Expertise. 2024;67(6):25‑29. (In Russ.)
https://doi.org/10.17116/sudmed20246706125

Подписка 2026 Судебно-медицинская экспертиза (Forensic Medical Expertise)

Использование инфографики авторами научных работ

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OBJECTIVE

To examine the changes in dermal mast cells density in the mechanically injured skin and to evaluate the applicability of dermal mast cells density increase as an injuries vitality diagnostic criteria (serial examination, statistically processed results).

MATERIAL AND METHODS

240 skin autopsy samples with mechanical injuries from 40 persons were divided to 3 groups (80 in each group): vital injuries, postmortal injuries, control non-injured samples. A routine histological examination using standard H&E stain and IHC with mast cells tryptase antibodies was performed consequented with histological slides full-format scanning and computer processing.

RESULTS AND CONCLUSION

An increase in the density of dermal mast cells relative to control samples was found in 80% of samples with vital injuries and in 50% with postmortem ones. Statistically significant differences in mast cell density were revealed between samples of all 3 groups, but they cannot be used as a reliable vitality diagnostic method.

Keywords:

injuries vitality

mast cells

tryptase

IHC

forensic pathology

Authors:

Kupriyanov D.D.

Russian Center of Forensic Medical Expertise

ORCID: 0000-0003-2730-1797

Fedulova M.V.

Russian Center of Forensic Medical Expertise

ORCID: 0000-0002-8787-2228

Received:

03.07.2024

Accepted:

08.07.2024

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References:

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