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Illarionova E.A.

Irkutsk State Medical University

Chmelevskaya N.V.

Irkutsk Regional Bureau of Forensic Medicine

Gonchikova Yu.A.

Irkutsk State Medical University

Tsyrenzhapov A.V.

Irkutsk State Medical University

Study of the possibility of emtricitabine extraction from biomaterial

Authors:

Illarionova E.A., Chmelevskaya N.V., Gonchikova Yu.A., Tsyrenzhapov A.V.

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Journal: Forensic Medical Expertise. 2023;66(3): 40‑45

DOI: 10.17116/sudmed20236603140

Read: 1638 times

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Table of contents

STUDY OF THE POSSIBILITY OF EMTRICITABINE EXTRACTION FROM BIOMATERIAL
STUDY OF THE POSSIBILITY OF EMTRICITABINE EXTRACTION FROM BIOMATERIAL

To cite this article:

Illarionova EA, Chmelevskaya NV, Gonchikova YuA, Tsyrenzhapov AV. Study of the possibility of emtricitabine extraction from biomaterial. Forensic Medical Expertise. 2023;66(3):40‑45. (In Russ.)
https://doi.org/10.17116/sudmed20236603140

Подписка 2026 Судебно-медицинская экспертиза (Forensic Medical Expertise)
МСФ на ЯМ
Использование инфографики авторами научных работ
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Recommended articles:
Study of the possibility of isolating atazanavir from biological fluids for the purpose of chemical-toxicological analysis. Fore­nsic Medi­cal Expe­rtise. 2026;(2):32-36
Abstract:

THE AIM OF THE STUDY

Is to investigate the opportunity of emtricitabine extraction from biomaterial and to develop method of emtricitabine chemicotoxicological analysis while acute poisoning. This research represents the methods of emtricitabine isolation from urine, plasma and liver samples (rats of Wistar line weighing 180 g) using liquid-liquid extraction. The identification and quantitation methods of emtricitabine in extractions by thin-layer chromatography, ultraviolet spectrophotometry and high-performance liquid chromatography methods were described. The emtricitabine was found extracted from urine with a therapeutic dose of 6.65±2.21 µg/ml and a toxic dose 35.81±1.05 µg/ml, from plasma with a therapeutic dose of 2.91±0.19 µg/ml and a toxic dose of 16.88±0.90 µg/ml.

Keywords:

emtricitabine
liquid-liquid extraction
UV spectrophotometry
thin-layer chromatography
high-performance chromatography

Authors:

Illarionova E.A.

Irkutsk State Medical University

Chmelevskaya N.V.

Irkutsk Regional Bureau of Forensic Medicine

Gonchikova Yu.A.

Irkutsk State Medical University

Tsyrenzhapov A.V.

Irkutsk State Medical University

Received:

14.09.2022

Accepted:

13.10.2022

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References:

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