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Kalekin R.A.

Laboratoriia sudebno-khimicheskikh i khimiko-toksikologicheskikh issledovaniĭ FGBU "Rossiĭskiĭ tsentr sudebno-meditsinskikh kspertiz" Minzdrava Rossii, Moskva, Rossiia, 125284

Orlova A.M.

Laboratoriia sudebno-khimicheskikh i khimiko-toksikologicheskikh issledovaniĭ FGBU "Rossiĭskiĭ tsentr sudebno-meditsinskoĭ ékspertizy" Minzdravsotsrazvitiia Rossii, Moskva

Savchuk S.A.

Department of Special Laboratory Investigations, Federal state budgetary institution «Russian Centre of Forensic Medical Expertise», Ministry of Health of the Russia, Moscow, Russia, 125284;
Laboratory of Pharmacokinetics and Metabolomic Analysis, Institute of Translational Medicine and Biotechnology of I.M. Sechenov First Moscow State Medical University, Moscow, Russia, 119992

Barsegian S.S.

Biuro sudebno-meditsinskoĭ ékspertizy Departamenta zdravookhraneniia Moskvy

The study of fenspiride: goals and objectives for chemical and toxicological studies

Authors:

Kalekin R.A., Orlova A.M., Savchuk S.A., Barsegian S.S.

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Journal: Forensic Medical Expertise. 2019;62(4): 37‑41

DOI: 10.17116/sudmed20196204137

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THE STUDY OF FENSPIRIDE: GOALS AND OBJECTIVES FOR CHEMICAL AND TOXICOLOGICAL STUDIES
THE STUDY OF FENSPIRIDE: GOALS AND OBJECTIVES FOR CHEMICAL AND TOXICOLOGICAL STUDIES

To cite this article:

Kalekin RA, Orlova AM, Savchuk SA, Barsegian SS. The study of fenspiride: goals and objectives for chemical and toxicological studies. Forensic Medical Expertise. 2019;62(4):37‑41. (In Russ.)
https://doi.org/10.17116/sudmed20196204137

Подписка 2026 Судебно-медицинская экспертиза (Forensic Medical Expertise)
МСФ на ЯМ
Использование инфографики авторами научных работ
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Abstract:

The purpose of this work is to study fenspiride for the purposes and tasks of chemical and toxicological research. The technique of chemical-toxicological study of fenspiride in urine by preliminary and confirming methods is proposed. The authors proposed a method of thin - layer chromatography in the solvent system of acetone — 25% ammonia solution (9:1) in a preliminary study of fenspiride. The Rf value of fenspiride is 0.80±0.02. The degree of extraction when used as an extractant mixture of chloroform—propanol (9:1) is 28.1±1.4% The conditions for identification of fenspiride by gas chromatography-mass spectrometry (fenspiride retention time 11.1±0.1 minutes), followed by quantitative determination of the analyte, are proposed as a confirming method. The conditions for qualitative (retention time of fenspiride 8.1±0.1 minutes) and quantitative determination of fenspiride by high-performance liquid chromatography are proposed.

Keywords:

fenspiride
eurespal
epistat
ericerus
eryspirus
pregabalin
chemical-toxicological study

Authors:

Kalekin R.A.

Laboratoriia sudebno-khimicheskikh i khimiko-toksikologicheskikh issledovaniĭ FGBU "Rossiĭskiĭ tsentr sudebno-meditsinskikh kspertiz" Minzdrava Rossii, Moskva, Rossiia, 125284

Orlova A.M.

Laboratoriia sudebno-khimicheskikh i khimiko-toksikologicheskikh issledovaniĭ FGBU "Rossiĭskiĭ tsentr sudebno-meditsinskoĭ ékspertizy" Minzdravsotsrazvitiia Rossii, Moskva

Savchuk S.A.

Department of Special Laboratory Investigations, Federal state budgetary institution «Russian Centre of Forensic Medical Expertise», Ministry of Health of the Russia, Moscow, Russia, 125284;
Laboratory of Pharmacokinetics and Metabolomic Analysis, Institute of Translational Medicine and Biotechnology of I.M. Sechenov First Moscow State Medical University, Moscow, Russia, 119992

Barsegian S.S.

Biuro sudebno-meditsinskoĭ ékspertizy Departamenta zdravookhraneniia Moskvy

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References:

  1. Registr lekarstvenny`kh sredstv Rossii: Enciklopediya lekarstv. Izd. 23-e. M.: OOO RLS-2014, 2014;1392. (In Russ.)
  2. URL: https://www.secret-dolgolet.ru/erespal/ URL: https://rosregistr.ru/e229466/html Accessed 01.03.2019
  3. URL:https://grls.rosminzdrav.ru/GRLS.aspx?RegNumber=&MnnR=%d1%84%d0%b5%d0%bd%d1%81%d0%bf%d0%b8%d1%80%d0%b8%d0%b4&lf=&TradeNmR=&OwnerName=&MnfOrg=&MnfOrgCountry=&isfs=0&isND=0&order=RegDate&orderType=desc&RegType=&pageSize=10&pageNum=5 URL:http://www.roszdravnadzor.ru/i/upload/images/2019/2/14/1550157442.84349-1-387.pdf Accessed 01.03.19
  4. Sauveur C, Baune A, Vergnes N, Jeanniot PH. The determination of fenspiride in human plasma and urine by liquid chromatography with electrochemical or ultraviolet detection. Journal of Pharmaceutical &Biomedical Analysis. 1989;7(12):1799-1804.
  5. Pidpruzhnykov YuV, Sabko VE, Iurchenko VV, Zupanets IA. UPLC-MS/MS Quantification of Fenspiride in Human Plasma. J Bioequiv Availab. 2013;5(4):185-190. https://doi.org/10.4172/jbb.1000156
  6. Metodicheskie ukazaniya 4.1.3177-14 Izmerenie koncentracii 8-(2-fenile`til)-1-oksa-3,8-diazaspiro[4,5]-dekan-2-ona gidroxlorida (fenspirida gidroxlorid, erespal) v vozduxe rabochej zony metodom spektrofotometrii. Federal`naya sluzhba po nadzoru v sfere zashhity prav potrebitelej i blagopoluchiya cheloveka. 2014;24. (In Russ.)
  7. Orlova AM. The analysis of publications on toxicological (forensic) chemistry in the journal «Forensic medical examination» for the period 2004—2013. Message 2. Analysis and evaluation of publications, peculiarities of research development. Sudebno-meditsinskaya ekspertiza. 2016;59(1):52-59. (In Russ.)
  8. Kartashov VA, Chernova LV, Velichko GP. TLC-screening and retention indices of toxic substances. Novye texnologii. 2012;2:240-247. (In Russ.)
  9. Kalekin RA. Determination of neuroleptics-derivatives of benzamide by thin-layer chromatography. Klinicheskaya laboratornaya diagnostika. 2013;2:19-20. (In Russ.)
  10. Salomatin EM, Kalekin RA, Orlova AM, Valueva MI. Features and prospects of research of ptomains for the purposes of forensic chemical analysis. Sudebno-meditsinskaya ekspertiza. 2015;58(6):49-52. (In Russ.)
  11. Kalekin RA. Determination of neuroleptics-derivatives of benzamide by thin-layer chromatography. Klinicheskaya laboratornaya diagnostika. 2013;2:19-20. (In Russ.)
  12. Salomatin EM, Kalekin RA, Orlova AM, Valueva MI. Features and prospects of research of ptomains for the purposes of forensic chemical analysis. Sudebno-meditsinskaya ekspertiza. 2015;58(6):49-52. (In Russ.)
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