This article was designed to report the results of the comprehensive clinical and morphological analysis of the cases of death from the complications of burn disease based on the available medical documentation, the results of autopsies, and the data obtained in the histological and biochemical investigations. The study made it possible to reveal and identify the most typical, reliable, and stable intravital clinical and laboratory features of sepsis developing in burned individuals as well as postmortem pathomorphological and biochemical changes characterizing this condition supposed to be the immediate cause of death. The results of the study may be used to enhance the objectiveness and the level of evidence of expert conclusions concerning the cause of death of the patients presenting with burn disease and developing complications during its late period.