The peculiar features of the distribution of 2-(dimethylamino)ethyl- (1-hydroxycyclopentyl) (phenyl) acetate in the organism of warm-blooded animals after its intravenous administration

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Shormanov V.K.

Kurskiĭ gosudarstvennyĭ meditsinskiĭ universitet

Pravdyuk M.F.

Republican Narcological Dispensary, Ministry of Health, Republic of North Ossetia, Vladikavkaz, Russia, 362027

The peculiar features of the distribution of 2-(dimethylamino)ethyl- (1-hydroxycyclopentyl) (phenyl) acetate in the organism of warm-blooded animals after its intravenous administration

Authors:

Shormanov V.K., Pravdyuk M.F.

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Journal: Forensic Medical Expertise. 2017;60(5): 27‑33

DOI: 10.17116/sudmed201760527-33

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To cite this article:

Shormanov VK, Pravdyuk MF. The peculiar features of the distribution of 2-(dimethylamino)ethyl- (1-hydroxycyclopentyl) (phenyl) acetate in the organism of warm-blooded animals after its intravenous administration. Forensic Medical Expertise. 2017;60(5):27‑33. (In Russ.)
https://doi.org/10.17116/sudmed201760527-33

Подписка 2026 Судебно-медицинская экспертиза (Forensic Medical Expertise)

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Abstract:

The objective of the present study was to elucidate the dynamics of the distribution of 2-(dimethylamino)ethyl-(1-hydroxycyclopentyl)(phenyl) acetate in the organism of warm-blooded animals (rats) after its intravenous administration to the animals. The identification and the quantitative determination of 2-(dimethylamino)ethyl-(1-hydroxycyclopentyl)(phenyl) acetate present in the organs and blood of the warm-blooded animals were carried out with the use of chromatography in a thin layer of silica gel, chromogenic reaction for the synthesis of the acinitro salt, UV spectrophotometry, and gas chromatography mass-spectrometry (GCh-MS). The quantitation was performed on days 5, 20, 150, and 360 minutes after the intravenous administration of 2-(dimethylamino)ethyl-(1-hydroxycyclopentyl)(phenyl) acetate to the rats. The maximum amounts of cyclopentolate were found in the spleen, brain, lungs, and heart of the experimental animals.

Keywords:

2-(dimethylamino)ethyl-(1-hydroxycyclopentyl)(phenyl) acetate

intravenous administration

distribution in the organism

chemical toxicological analysis

Authors:

Shormanov V.K.

Kurskiĭ gosudarstvennyĭ meditsinskiĭ universitet

Pravdyuk M.F.

Republican Narcological Dispensary, Ministry of Health, Republic of North Ossetia, Vladikavkaz, Russia, 362027

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References:

British Pharmacopoeia. London: HMSO; 1993;1.
Cyclopentolate. Chem Spider. Accessed 2017 January 9. http://www.chemspider.com/ Chemical-Structure.2802.html
Arici C, Turk A, Ceylan OM, Kola M, Hurmeric V. Effects of 1% cyclopentolate hydrochloride on anterior segment parameters obtained with Pentacam in young adults. Arq Bras Oftalmol. 2014;77(4):228-232. https://doi.org/10.5935/0004-2749.20140059
Bolinovska S, Popović J. Cyclopentolate as a cycloplegic drug in determination of refractive error. Med Pregl. 2008;61(7-8):327-332.
Szwed K, Górecki АM, Frelek J, Asztemborska M. Enantioselective Extraction System Containing Binary Chiral Selectors and Chromatographic Enantioseparation Method for Determination of the Absolute Configuration of Enantiomers of Cyclopentolate. Chromatographia. 2013;76(23):1603-1611. https://doi.org/10.1007/s10337-013-2538-z
Cyclopentolate. Drug Bank. Available at: https://www.drugbank.ca/drugs/DB00979. Accessed 2017 January 9.
Pharmaceutical Manufacturing Encyclopedia.-3rd Edition. Norwich—New York: William Andrew Publishing; 2007.
Fedorov DB, Kireeva AV, Chihvatova YuK, Kuklin VN. Chemical and toxicological research of the drug tsiklomed. Sudebno-medicinskaya ekspertiza. 2015;58(5):30-35. (In Russ.). https://doi.org/10.17116/sudmed201558430-35
Görgülü Y, Ateş IÇ, Çınar RK, Sönmez MB. Cyclopentolate use disorder: a case report of intranasal misuse. Bağımlılık Dergisi. Journal of Dependence. 2015;16(1):39-42.
Mohnachev SO, Rohlina ML, Usmanova NN. The abuse of cyclopentolate (tsiklomed). Narkologiya. 2010;(10):40-44. (In Russ.).
Tayman C, Mete E, Catal F, Akca H. Аnaphylactic reaction due to cyclopentolate in a 4-year-old child. J Investig Allergol Clin Immunol. 2010;20(4):347-348.
Calisaneller T, Ozdemir O, Sonmez E, Altinors N. Acute progressive midbrain hemorrhage after topical ocular cyclopentolate administration. Neurology India. 2008;56(1):88-89. https://doi.org/10.4103/0028-3886.39324
Shormanov VK, Pravduk MF. The proof of poisoning tropicamide, introduced into the stomach of warm-blooded, based on the detection of blood in the organs and the source of the toxic agent and structurally related compounds. Chelovek i ego zdorovie. 2015;(2):96-101. (In Russ.).
Shormanov VK, Pravduk MF, Cheked MV, Barannikova VV. Tropicamide distribution in the body of warm-blooded animals by intragastric administration. Sudebno-medicinskaya ekspertiza. 2016;59(2):27-34. (In Russ.). https://doi.org/10.17116/sudmed201659227–34.

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